Palladium-catalyzed allylic alkylation enabled by ketone umpolung via Pudovik addition/[1,2]-phospha-Brook rearrangement

Palladium-catalyzed allylic alkylation enabled by ketone umpolung via Pudovik addition/[1,2]-phospha-Brook rearrangement with phosphites has been developed.The protocol offers a straightforward method for the synthesis of potentially bioactive homoallylic alcohol phosphonates in an efficient and economical way.This cascade reaction proceeds under mild conditions with excellent functional group compatibility.Furthermore,the catalytic asymmetric version has also been explored.

Transition-metal-catalyzed aromatic C–H functionalization assisted by the phosphorus-containing directing groups

Transition-metal-catalyzed C–H bond functionalization has attracted tremendous attention as an increasingly important protocol for the construction of C–C and C–X bonds.In particular,C–H bond functionalization assisted by the phosphorus-containing directing groups has made significant progress in the past few years.A series of valuable phosphorous compounds,especially phosphine ligands have been provided conveniently.This review comprehensively describes recent advances in transition-metal-catalyzed C–H bond functionalization assisted by the phosphorus-containing directing groups,highlights its potential applications in organic synthesis,and gives some insights into future advances.

手性环戊二烯基铑络合物在C–H键官能团化反应中的应用

Transition-metal-catalyzed C–H functionalization is becoming a general and straightforward strategy for the construction of carbon-carbon and carbon-heteroatom bonds in modern organic synthesis.In this regard,ligands often play a key role for the C–H functionalization processes.