Background: Much is known about the worldwide rising incidence of skin cancers in the white populations. However,contradictory reports have been presented about a genderlinked risk for malignant melanoma (MM). Objecti...Background: Much is known about the worldwide rising incidence of skin cancers in the white populations. However,contradictory reports have been presented about a genderlinked risk for malignant melanoma (MM). Objective: To review the recent epidemiological information about primary and metastatic MM in south-east Belgium. Methods: Laboratory records of primary MM according to age and gender were compared per 3-year periods from 1988 to 2002. The numbers of MM per decade of patient age were corrected with regard to the number of citizens in the defi ned periods of age. This led to the calculation of the rate of estimated prevalence (REP). The same assessments were performed on 187 sentinel lymph node biopsies collected during the last 3-year period. Results: A total of 1,051 primary MM in women and 594 primary MM in men were diagnosed over the 15-year period. The femaleto-male ratio rose by 24%over time,with a mean value of 1.77. The most recent years showed a marked increase both in the numbers and REP of primary MM. This situationwas present in both genders,although it was most prominent in women of the reproductive age. MM metastases were found in 38/187 sen-tinel lymph nodes with a female-tomale ratio of 2.17. The age distribution for all sentinel lymph node biopsies copied that of primary MM,but the vast majority of the nodal metastatic MM was found in patients older than 50 years. The ratio between MMmetastases and primary MM reached 6.1%(12/198) inmen and 6.9%(26/378) in women. Conclusion: A recent increase in primary MM incidence was observed in our laboratory. The most likely cause is ascribed to more sensitive MM detection using the combination of clinical dermoscopy and laboratory immunohistochemistry. During the past 15 years,women were more affected than men by both primary and metastatic MM. The gender difference in incidence of primary MM has progressively widened due to an increased incidence in young and middle-agedwomen. By contrast,nodalmetastatic MM mostly affected postmenopausal women.展开更多
Myospherulosis is a rare disorder that may develop in various organs including the skin. It is characterized by a typical histological presentation resulting from the interaction between erythrocytes and lipids. We pr...Myospherulosis is a rare disorder that may develop in various organs including the skin. It is characterized by a typical histological presentation resulting from the interaction between erythrocytes and lipids. We present a case of cutaneous myospherulosis associated with membranous lipodystrophy. The lesions were supervening on severe steroid-induced skin atrophy upon which ointments had been applied.展开更多
Two cases of diffuse dermal angiomatosis are reported in middle-aged women. This rare disease of unknown origin is characterized by increased dermal angiomatosis and ulceration. The clinical and histologic presentatio...Two cases of diffuse dermal angiomatosis are reported in middle-aged women. This rare disease of unknown origin is characterized by increased dermal angiomatosis and ulceration. The clinical and histologic presentations of the presently reported lesions were typical for this disorder. Endothelial cells exhibited a normal immunophenotype. The perivascular basement membranes showed a distribution of collagen αchains typical for blood vessels, but not for lymphatics. Immunohistochemistry revealed other undescribed features. At the site of the clinical lesions, linear and granular deposits of immunoglobulins A and M, and complement were found around the vessels and at the dermal-epidermal junction. The same deposits were also found restricted to the dermal-epidermal junction in the peripheral clinically intact skin. No serological signs of auto-immune disorder were detected in one patient. A monoclonal gammopathy was disclosed in the other patient. A pattern of immunoreactant deposits similar to that disclosed in the two patients was not found in the control specimens, and has not been described so far in other types of vascular hyperplasia and neoplasia. A pathogenic role of these deposits is unsettled and should be further explored.展开更多
文摘Background: Much is known about the worldwide rising incidence of skin cancers in the white populations. However,contradictory reports have been presented about a genderlinked risk for malignant melanoma (MM). Objective: To review the recent epidemiological information about primary and metastatic MM in south-east Belgium. Methods: Laboratory records of primary MM according to age and gender were compared per 3-year periods from 1988 to 2002. The numbers of MM per decade of patient age were corrected with regard to the number of citizens in the defi ned periods of age. This led to the calculation of the rate of estimated prevalence (REP). The same assessments were performed on 187 sentinel lymph node biopsies collected during the last 3-year period. Results: A total of 1,051 primary MM in women and 594 primary MM in men were diagnosed over the 15-year period. The femaleto-male ratio rose by 24%over time,with a mean value of 1.77. The most recent years showed a marked increase both in the numbers and REP of primary MM. This situationwas present in both genders,although it was most prominent in women of the reproductive age. MM metastases were found in 38/187 sen-tinel lymph nodes with a female-tomale ratio of 2.17. The age distribution for all sentinel lymph node biopsies copied that of primary MM,but the vast majority of the nodal metastatic MM was found in patients older than 50 years. The ratio between MMmetastases and primary MM reached 6.1%(12/198) inmen and 6.9%(26/378) in women. Conclusion: A recent increase in primary MM incidence was observed in our laboratory. The most likely cause is ascribed to more sensitive MM detection using the combination of clinical dermoscopy and laboratory immunohistochemistry. During the past 15 years,women were more affected than men by both primary and metastatic MM. The gender difference in incidence of primary MM has progressively widened due to an increased incidence in young and middle-agedwomen. By contrast,nodalmetastatic MM mostly affected postmenopausal women.
文摘Myospherulosis is a rare disorder that may develop in various organs including the skin. It is characterized by a typical histological presentation resulting from the interaction between erythrocytes and lipids. We present a case of cutaneous myospherulosis associated with membranous lipodystrophy. The lesions were supervening on severe steroid-induced skin atrophy upon which ointments had been applied.
文摘Two cases of diffuse dermal angiomatosis are reported in middle-aged women. This rare disease of unknown origin is characterized by increased dermal angiomatosis and ulceration. The clinical and histologic presentations of the presently reported lesions were typical for this disorder. Endothelial cells exhibited a normal immunophenotype. The perivascular basement membranes showed a distribution of collagen αchains typical for blood vessels, but not for lymphatics. Immunohistochemistry revealed other undescribed features. At the site of the clinical lesions, linear and granular deposits of immunoglobulins A and M, and complement were found around the vessels and at the dermal-epidermal junction. The same deposits were also found restricted to the dermal-epidermal junction in the peripheral clinically intact skin. No serological signs of auto-immune disorder were detected in one patient. A monoclonal gammopathy was disclosed in the other patient. A pattern of immunoreactant deposits similar to that disclosed in the two patients was not found in the control specimens, and has not been described so far in other types of vascular hyperplasia and neoplasia. A pathogenic role of these deposits is unsettled and should be further explored.
