Cutaneous squamous cell carcinoma(cSCC)is the second most common skin tumor in humans.Ultraviolet(UV)radiation is an important environmental risk factor for cSCC;other risk factors include human papilloma virus(HPV)in...Cutaneous squamous cell carcinoma(cSCC)is the second most common skin tumor in humans.Ultraviolet(UV)radiation is an important environmental risk factor for cSCC;other risk factors include human papilloma virus(HPV)infection,chronic inflammation,and chronic wounds.A large proportion of patients present with an aggressive form of cSCC at the time of diagnosis,which is often accompanied by regional lymph node involvement and distant metastases.The long-term prognosis for these highly metastatic diseases is extremely poor,with a 10-year survival rate of less than 10%.Therefore,clarifying the pathogenesis of this tumor is of great significance and may contribute to the identification of novel biomarkers and development of new therapeutic strategies.In this review,we focus on the recent progress in genes related to the development of this tumor,intending to aid future investigations into the genetic alterations related to cSCC.展开更多
Introduction Cutaneous squamous cell carcinoma (CSCC),a keratinocyte-derived skin neoplasm with malignant potential,1 represents 20%-50% of skin cancers and currently has an increasing incidence in the United States.2...Introduction Cutaneous squamous cell carcinoma (CSCC),a keratinocyte-derived skin neoplasm with malignant potential,1 represents 20%-50% of skin cancers and currently has an increasing incidence in the United States.2 Ultraviolet (UV)solar radiation is the primary risk factor for the development of CSCC,and the cumulative exposure received over a lifetime plays a major role in this development.3 Mutations in the p53 gene are the most common genetic abnormalities,causing nonfunctional p53 protein production and cells with damaged DNA replicate in CSCC.展开更多
Introduction Cutaneous squamous cell carcinoma(CSCC)is the secondmost common non-melanoma skin cancer after basal cell carcinoma,accounting for 20%of all cutaneous malignancies.CSCC originates from epidermal keratinoc...Introduction Cutaneous squamous cell carcinoma(CSCC)is the secondmost common non-melanoma skin cancer after basal cell carcinoma,accounting for 20%of all cutaneous malignancies.CSCC originates from epidermal keratinocytes or adnexal structures such as eccrine glands or pilosebaceous units.1 According to several studies focused on Caucasian populations in Europe,the USA and Australia,about 15–35 per 100,000 individuals are diagnosed with CSCC each year,and the incidence of CSCC is expected to increase by 2%–4%per year.2 The incidence of primary CSCC has increased by 50%–300%globally,especially amongst Caucasian populations in New Zealand,Australia,and North America over the last 3 decades.展开更多
基金Supported by the Natural Science Foundation of Jiangsu Province(No.BK20191136)the Fundamental Research Funds for the Central Universities(No.3332019104)the Open Project of Jiangsu Biobank of Clinical Resources(No.JSSWYB2020-05-003).
文摘Cutaneous squamous cell carcinoma(cSCC)is the second most common skin tumor in humans.Ultraviolet(UV)radiation is an important environmental risk factor for cSCC;other risk factors include human papilloma virus(HPV)infection,chronic inflammation,and chronic wounds.A large proportion of patients present with an aggressive form of cSCC at the time of diagnosis,which is often accompanied by regional lymph node involvement and distant metastases.The long-term prognosis for these highly metastatic diseases is extremely poor,with a 10-year survival rate of less than 10%.Therefore,clarifying the pathogenesis of this tumor is of great significance and may contribute to the identification of novel biomarkers and development of new therapeutic strategies.In this review,we focus on the recent progress in genes related to the development of this tumor,intending to aid future investigations into the genetic alterations related to cSCC.
基金supported by Grants from the Chinese Academy Medical Sciences Initiative for Innovative Medicine (No. 2016I2M-3-021)National Natural Science Foundation of China (No. 31470274)+1 种基金Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs (No. 2012ZD006)Jiangsu provincial SixTalent Peaks (No. 2013-WSW-060)
文摘Introduction Cutaneous squamous cell carcinoma (CSCC),a keratinocyte-derived skin neoplasm with malignant potential,1 represents 20%-50% of skin cancers and currently has an increasing incidence in the United States.2 Ultraviolet (UV)solar radiation is the primary risk factor for the development of CSCC,and the cumulative exposure received over a lifetime plays a major role in this development.3 Mutations in the p53 gene are the most common genetic abnormalities,causing nonfunctional p53 protein production and cells with damaged DNA replicate in CSCC.
基金supported by grants from the Chinese Academy Medical Sciences Initiative for Innovative Medicine(2016-I2M-3-021)National Natural Science Foundation of China(31470274)+1 种基金Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs(2012ZD006)Jiangsu provincial SixTalent Peaks(2013-WSW-060).
文摘Introduction Cutaneous squamous cell carcinoma(CSCC)is the secondmost common non-melanoma skin cancer after basal cell carcinoma,accounting for 20%of all cutaneous malignancies.CSCC originates from epidermal keratinocytes or adnexal structures such as eccrine glands or pilosebaceous units.1 According to several studies focused on Caucasian populations in Europe,the USA and Australia,about 15–35 per 100,000 individuals are diagnosed with CSCC each year,and the incidence of CSCC is expected to increase by 2%–4%per year.2 The incidence of primary CSCC has increased by 50%–300%globally,especially amongst Caucasian populations in New Zealand,Australia,and North America over the last 3 decades.
