Study on Building and Modeling of Virtual Data of Xiaosha River Artificial Wetland

From the viewpoint of systems science, this article takes Xiaosha River artificial wetland under planning and construction as object of study based on the systems theory and takes the accomplished and running project of Xinxuehe artificial wetland as reference. The virtual data of quantity and quality of inflow and the quality of outflow of Xiaosha River artificial wetland are built up according to the running experience, forecasting model and theoretical method of the reference project as well as the comparison analysis of the similarity and difference of the two example projects. The virtual data are used to study the building of forecasting model of BP neural network of Xiaosha River artificial wetland.

Targeting FAPα-positive lymph node metastatic tumor cells suppresses colorectal cancer metastasis

Lymphatic metastasis is the main metastatic route for colorectal cancer, which increases the risk of cancer recurrence and distant metastasis. The properties of the lymph node metastatic colorectal cancer(LNM-CRC) cells are poorly understood, and effective therapies are still lacking. Here, we found that hypoxia-induced fibroblast activation protein alpha(FAPα) expression in LNM-CRC cells. Gain-or loss-function experiments demonstrated that FAPα enhanced tumor cell migration, invasion, epithelial-mesenchymal transition, stemness, and lymphangiogenesis via activation of the STAT3 pathway. In addition, FAPα in tumor cells induced extracellular matrix remodeling and established an immunosuppressive environment via recruiting regulatory T cells, to promote colorectal cancer lymph node metastasis(CRCLNM). Z-GP-DAVLBH, a FAPα-activated prodrug, inhibited CRCLNM by targeting FAPα-positive LNM-CRC cells. Our study highlights the role of FAPα in tumor cells in CRCLNM and provides a potential therapeutic target and promising strategy for CRCLNM.