Objective:To investigate the economic burden of patients with acute kidney injury(AKI)by analyzing the distribution of hospitalization expenses and its influencing factors in the Affiliated Hospital of Hebei Universit...Objective:To investigate the economic burden of patients with acute kidney injury(AKI)by analyzing the distribution of hospitalization expenses and its influencing factors in the Affiliated Hospital of Hebei University.Methods:The hospitalization information of patients with AKI from January 2020 to January 2023 was collected and sorted through the hospital charging system and the factors affecting the total hospitalization cost were analyzed by multiple linear regression.Results:Univariate analysis showed that age,occupation,marriage,length of hospitalization,recovery of renal function,and stage of AKI had significant effects on hospitalization cost(P<0.05).The result of the multiple linear regression analysis model showed that age(t=4.11,P<0.0001),length of hospitalization(t=16.10,P<0.0001),recovery of renal function(t=3.26,P<0.0001),AKI stage(t=5.23,P=0.002)are factors affecting the economic burden of patients with AKI.Conclusion:AKI patients should be managed according to age stratification to effectively control the progression of the disease and improve the quality of the medical services provided.This will reduce the economic burden of patients.展开更多
By using the method of literature review, this paper introduces the popular theoretical models which have shown to better explain physical activity behaviors at a certain degree, summarizes the dominating theoretical ...By using the method of literature review, this paper introduces the popular theoretical models which have shown to better explain physical activity behaviors at a certain degree, summarizes the dominating theoretical models in the studies of physical activity behaviors of the elderly in China. In addition, shortcomings and future prospects are pointed out at the end.展开更多
Purpose： Macrophages are known to be important for healing numerous injured tissues depending on their functional phenotypes in response to different stimuli. The objective of this study was to reveal macrophage phen...Purpose： Macrophages are known to be important for healing numerous injured tissues depending on their functional phenotypes in response to different stimuli. The objective of this study was to reveal macrophage phenotypic changes involved in exercise-induced skeletal muscle injury and regeneration. Methods： Adult male Sprague-Dawley rats experienced one session of downhill running （16~ decline, 16 m/min） for 90 min. After exercise the blood and soleus muscles were collected at 0 h, 6 h, 12 h, 1 d, 2 d, 3 d, 1 w and 2 w after exercise, separately. Results： It was showed that CD6B＋ M1 macrophages mainly infiltrated into musc｜e necrotic sites at 1-3 d, while CD163＋ M2 macrophages were present in muscles from 0 h to 2 weeks after exercise. Using transmission electron microscopy, we observed activated satellite cells 1 d after exercise. Thl-associated transcripts of iNOS and Cc12 were inhibited post exercise, while COX-2 mRNA was dramatically increased 12 h after running （p 〈 0.01 ）. M2 phenotype marker Arg-1 increased 12 h and 3 d （p 〈 0.05, p 〈 0.01 ） after exercise, and Clecl0a and Mrc2 were up-regulated in muscles 12 h following exercise （p 〈 0.05, p 〈 0.05）. Conclusion： The data demonstrate the dynamic patterns of macrophage phenotype in skeletal muscle upon eccentric exercise stimuli, and M1 and M2 phenotypes perform different functions during exercise- induced skeletal muscle injury and recovery.展开更多
文摘Objective:To investigate the economic burden of patients with acute kidney injury(AKI)by analyzing the distribution of hospitalization expenses and its influencing factors in the Affiliated Hospital of Hebei University.Methods:The hospitalization information of patients with AKI from January 2020 to January 2023 was collected and sorted through the hospital charging system and the factors affecting the total hospitalization cost were analyzed by multiple linear regression.Results:Univariate analysis showed that age,occupation,marriage,length of hospitalization,recovery of renal function,and stage of AKI had significant effects on hospitalization cost(P<0.05).The result of the multiple linear regression analysis model showed that age(t=4.11,P<0.0001),length of hospitalization(t=16.10,P<0.0001),recovery of renal function(t=3.26,P<0.0001),AKI stage(t=5.23,P=0.002)are factors affecting the economic burden of patients with AKI.Conclusion:AKI patients should be managed according to age stratification to effectively control the progression of the disease and improve the quality of the medical services provided.This will reduce the economic burden of patients.
文摘By using the method of literature review, this paper introduces the popular theoretical models which have shown to better explain physical activity behaviors at a certain degree, summarizes the dominating theoretical models in the studies of physical activity behaviors of the elderly in China. In addition, shortcomings and future prospects are pointed out at the end.
文摘Purpose： Macrophages are known to be important for healing numerous injured tissues depending on their functional phenotypes in response to different stimuli. The objective of this study was to reveal macrophage phenotypic changes involved in exercise-induced skeletal muscle injury and regeneration. Methods： Adult male Sprague-Dawley rats experienced one session of downhill running （16~ decline, 16 m/min） for 90 min. After exercise the blood and soleus muscles were collected at 0 h, 6 h, 12 h, 1 d, 2 d, 3 d, 1 w and 2 w after exercise, separately. Results： It was showed that CD6B＋ M1 macrophages mainly infiltrated into musc｜e necrotic sites at 1-3 d, while CD163＋ M2 macrophages were present in muscles from 0 h to 2 weeks after exercise. Using transmission electron microscopy, we observed activated satellite cells 1 d after exercise. Thl-associated transcripts of iNOS and Cc12 were inhibited post exercise, while COX-2 mRNA was dramatically increased 12 h after running （p 〈 0.01 ）. M2 phenotype marker Arg-1 increased 12 h and 3 d （p 〈 0.05, p 〈 0.01 ） after exercise, and Clecl0a and Mrc2 were up-regulated in muscles 12 h following exercise （p 〈 0.05, p 〈 0.05）. Conclusion： The data demonstrate the dynamic patterns of macrophage phenotype in skeletal muscle upon eccentric exercise stimuli, and M1 and M2 phenotypes perform different functions during exercise- induced skeletal muscle injury and recovery.
