The authors regret<that the SEM image of G12 hydrogel in Fig.2f was wrongly used during the assembly of Fig.2.The authors had checked the original data and replaced Fig.2f with the correction image.This error does ...The authors regret<that the SEM image of G12 hydrogel in Fig.2f was wrongly used during the assembly of Fig.2.The authors had checked the original data and replaced Fig.2f with the correction image.This error does not affect the scientific conclusions of the article in any way.>.The authors would like to apologise for any inconvenience caused.展开更多
2-hydroxynaphthylidene-1′-naphthylamine(HNAN) and –NO_(2) modified HNAN(HNAN-NO_(2)) Schiff base compounds were synthesized and exhibited strong visible light absorption(<650 nm). These compounds were added to po...2-hydroxynaphthylidene-1′-naphthylamine(HNAN) and –NO_(2) modified HNAN(HNAN-NO_(2)) Schiff base compounds were synthesized and exhibited strong visible light absorption(<650 nm). These compounds were added to poly(vinylidene fluoride-trifluoroethylene)(P(VDF-Tr FE))ferroelectric polymer, obtaining composites with high photoelectric response under visible and infrared light. It was found that the modification of HNAN by the nitro group and the poling of the composites under a high electric field can greatly enhance the photoelectric response of the composites. The composites can generate high photovoltages of 1386 and352.7 mV under irradiation with near-infrared light(915 nm)and green light(532 nm). The mechanism of the photoelectric response of the composites under green light was explored and it was found that the response originates mainly from the coupling effect of the photothermal effect of the Schiff base and the pyroelectric effect of the ferroelectric polymer. The composites, which can be utilized as photodetector materials,are promising for next-generation artificial retina applications and the sensing capability of retina can be extended in a wide wavelength range from visible to infrared light.展开更多
In recent years,neurodegenerative diseases,such as Parkinson’s or Alzheimer’s diseases,are rapidly rising in prevalence.The main hallmark of Parkinson’s disease is the falling levels of neurotransmitter dopamine in...In recent years,neurodegenerative diseases,such as Parkinson’s or Alzheimer’s diseases,are rapidly rising in prevalence.The main hallmark of Parkinson’s disease is the falling levels of neurotransmitter dopamine in the mid-brain with dopaminergic neurons losing.Typical therapeutic solutions,including drugs,deep brain stimulation,and cell transplantation,can only alleviate the symptoms of Parkinson’s disease.It is a tremendous challenge to reverse the function degeneration of the crucial dopaminergic neurons.Herein,we develop a core-satellite-like nanoassembly(PDA-AFn(by integrating polydopamine nanoparticles and apoferritin))to raise the expression of tyrosine hydroxylase(TH),a rate-limiting enzyme in the formation of the dopamine.Both components in the nanoassembly could cooperate with each other,not only elaborately regulate the iron homeostasis and redox microenvironment,but also utilize excessive reactive oxygen species(ROS)and iron ions in the damaged neurons to supply extra dopamine and enhance TH activity,and consequently restore the function of the degenerated neurons.Remarkably,the nanoassembly-treatment relieves the dyskinesia and dramatical increases the tyrosine hydroxylase and dopamine level in the midbrain of Parkinson’s disease model mice.It is an explicit yet inspiring advance in treatment of the neurodegeneration.展开更多
文摘The authors regret<that the SEM image of G12 hydrogel in Fig.2f was wrongly used during the assembly of Fig.2.The authors had checked the original data and replaced Fig.2f with the correction image.This error does not affect the scientific conclusions of the article in any way.>.The authors would like to apologise for any inconvenience caused.
基金supported by the National Key Research and Development Program of China (2017YFA0701301)the National Natural Science Foundation of China (51373161 and51672261)。
文摘2-hydroxynaphthylidene-1′-naphthylamine(HNAN) and –NO_(2) modified HNAN(HNAN-NO_(2)) Schiff base compounds were synthesized and exhibited strong visible light absorption(<650 nm). These compounds were added to poly(vinylidene fluoride-trifluoroethylene)(P(VDF-Tr FE))ferroelectric polymer, obtaining composites with high photoelectric response under visible and infrared light. It was found that the modification of HNAN by the nitro group and the poling of the composites under a high electric field can greatly enhance the photoelectric response of the composites. The composites can generate high photovoltages of 1386 and352.7 mV under irradiation with near-infrared light(915 nm)and green light(532 nm). The mechanism of the photoelectric response of the composites under green light was explored and it was found that the response originates mainly from the coupling effect of the photothermal effect of the Schiff base and the pyroelectric effect of the ferroelectric polymer. The composites, which can be utilized as photodetector materials,are promising for next-generation artificial retina applications and the sensing capability of retina can be extended in a wide wavelength range from visible to infrared light.
基金This work was supported by National Natural Science Foundation of China(Nos.22175085 and 21875101)National Key Research and Development Program of China(No.2017YFA0701301)State Key Laboratory of Analytical Chemistry for Life Science(No.SKLACLS2219).
文摘In recent years,neurodegenerative diseases,such as Parkinson’s or Alzheimer’s diseases,are rapidly rising in prevalence.The main hallmark of Parkinson’s disease is the falling levels of neurotransmitter dopamine in the mid-brain with dopaminergic neurons losing.Typical therapeutic solutions,including drugs,deep brain stimulation,and cell transplantation,can only alleviate the symptoms of Parkinson’s disease.It is a tremendous challenge to reverse the function degeneration of the crucial dopaminergic neurons.Herein,we develop a core-satellite-like nanoassembly(PDA-AFn(by integrating polydopamine nanoparticles and apoferritin))to raise the expression of tyrosine hydroxylase(TH),a rate-limiting enzyme in the formation of the dopamine.Both components in the nanoassembly could cooperate with each other,not only elaborately regulate the iron homeostasis and redox microenvironment,but also utilize excessive reactive oxygen species(ROS)and iron ions in the damaged neurons to supply extra dopamine and enhance TH activity,and consequently restore the function of the degenerated neurons.Remarkably,the nanoassembly-treatment relieves the dyskinesia and dramatical increases the tyrosine hydroxylase and dopamine level in the midbrain of Parkinson’s disease model mice.It is an explicit yet inspiring advance in treatment of the neurodegeneration.
