A core-satellite-like nanoassembly reverses a decisive tyrosine hydroxylase loss in degenerative dopaminergic neurons

In recent years,neurodegenerative diseases,such as Parkinson’s or Alzheimer’s diseases,are rapidly rising in prevalence.The main hallmark of Parkinson’s disease is the falling levels of neurotransmitter dopamine in the mid-brain with dopaminergic neurons losing.Typical therapeutic solutions,including drugs,deep brain stimulation,and cell transplantation,can only alleviate the symptoms of Parkinson’s disease.It is a tremendous challenge to reverse the function degeneration of the crucial dopaminergic neurons.Herein,we develop a core-satellite-like nanoassembly(PDA-AFn(by integrating polydopamine nanoparticles and apoferritin))to raise the expression of tyrosine hydroxylase(TH),a rate-limiting enzyme in the formation of the dopamine.Both components in the nanoassembly could cooperate with each other,not only elaborately regulate the iron homeostasis and redox microenvironment,but also utilize excessive reactive oxygen species(ROS)and iron ions in the damaged neurons to supply extra dopamine and enhance TH activity,and consequently restore the function of the degenerated neurons.Remarkably,the nanoassembly-treatment relieves the dyskinesia and dramatical increases the tyrosine hydroxylase and dopamine level in the midbrain of Parkinson’s disease model mice.It is an explicit yet inspiring advance in treatment of the neurodegeneration.

在宽光谱范围内具有强光电响应的全有机复合材料

本文合成了席夫碱化合物2-hydroxynaphthylidene-1′-naphthylamine (HNAN)和硝基改性的HNAN (HNAN-NO_(2)).这两种化合物在可见光(<650 nm)下显示出强吸光性.我们将这些化合物与Poly(vinylidene fluoride-trifluoroethylene)(P(VDF-Tr FE))铁电聚合物复合,得到了在可见光和红外光下具有高光电响应的复合材料.研究发现,利用HNAN的硝基改性或高电场下对复合材料进行极化可以大大增强复合材料的光电响应.复合材料在近红外光(波长915 nm)下可产生1386 mV的光电压,而在绿光(532 nm)下可产生352.7 mV的光电压.本文还探索了复合材料在绿光下的光电响应的产生机理,发现其响应主要源于席夫碱的光热效应和铁电聚合物的热释电效应之间的耦合作用.该复合材料可作为光电材料应用于下一代人工视网膜的光响应材料,并使人工视网膜能够感知的光波段从可见光扩展到红外光.