期刊文献+
共找到2篇文章
< 1 >
每页显示 20 50 100
丹皮酚磺酸钠对免疫性结膜炎的治疗作用及机制 被引量:2
1
作者 曹兴伟 李群英 +2 位作者 米珍 秦伟 谢学军 《中华眼视光学与视觉科学杂志》 CAS CSCD 2018年第9期525-529,535,共6页
目的:探讨丹皮酚磺酸钠对小鼠实验性免疫性结膜炎的治疗作用及机制。方法:实验研究。采用随机数字表法将36只(72眼)Balb/c小鼠平均分为正常对照组(A组)、模型组(B组)、1%丹皮酚磺酸钠组(C组)、2%丹皮酚磺酸钠组(D组)、色甘酸钠滴眼液对... 目的:探讨丹皮酚磺酸钠对小鼠实验性免疫性结膜炎的治疗作用及机制。方法:实验研究。采用随机数字表法将36只(72眼)Balb/c小鼠平均分为正常对照组(A组)、模型组(B组)、1%丹皮酚磺酸钠组(C组)、2%丹皮酚磺酸钠组(D组)、色甘酸钠滴眼液对照组(E组)、奥洛他定滴眼液对照组(F组),每组6只。以鸡卵白蛋白(OVA)腹腔注射免疫B、C、D、E、F组建立免疫性结膜炎动物模型;7d后,A组和B组予磷酸缓冲盐溶液(PBS)滴眼,C、D组分别予1%、2%丹皮酚磺酸钠滴眼治疗,E、F组分别予色甘酸钠、奥洛他定滴眼液治疗。用药5d,最后1次用药后进行眼部临床症状评分。以甲苯胺蓝染色观察检测结膜组织切片肥大细胞脱颗粒(MCD)情况,酶联免疫吸附测定法(ELISA)检测各组小鼠血清的卵蛋白特异性免疫球蛋白E(OVA-sIgE)、干扰素γ(IFN-γ)及白介素4(IL-4)水平。所得数据组间比较采用单因素方差分析。结果:各组间症状评分差异具有统计学意义(F=38.72,P<0.001),其中B组症状评分明显高于A组(P<0.001),C、D、E、F组的症状评分均低于B组(均P<0.05)。各组间肥大细胞计数差异具有统计学意义(F=15.28,P<0.001),B组及各用药组肥大细胞脱颗粒计数均明显高于A组(均P<0.05)。C、D、E、F组小鼠血清中OVA-sIgE水平明显低于B组(P<0.05);A、C、D、E、F组小鼠血清中IFN-γ水平均明显高于B组(P<0.05),IL-4水平均明显低于B组(P<0.05)。结论:丹皮酚磺酸钠对实验性免疫性结膜炎具有治疗作用,能够稳定实验性免疫性结膜炎小鼠眼结膜组织中肥大细胞,抑制活化脱颗粒,下调小鼠血清中OVA-sIgE、IL-4水平及上调IFN-γ水平。 展开更多
关键词 丹皮酚磺酸钠 免疫性结膜炎 肥大细胞 特异性免疫球蛋白E 干扰素Γ 白介素4 小鼠
原文传递
Effect of Sc and Zr additions on microstructures and corrosion behavior of Al-Cu-Mg-Sc-Zr alloys 被引量:12
2
作者 Fangfang Sun Guiru liu Nash +4 位作者 qunying li Enzuo liu Chunnain He Chunsheng Shi Naiqin Zhao 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2017年第9期1015-1022,共8页
The effects of adding the alloy element Sc to Al alloys on strengthening, recrystallization and modification of the grain microstructure have been investigated. The combination of Sc and Zr alloying not only produces ... The effects of adding the alloy element Sc to Al alloys on strengthening, recrystallization and modification of the grain microstructure have been investigated. The combination of Sc and Zr alloying not only produces a remarkable synergistic effect of inhibition of recrystallization and refinement of grain size but also substantially reduce the amount of high-cost additional Sc. In this work, the microstructures and corrosion behavior of a new type of Al-Cu-Mg-Sc-Zr alloy with Sc/Zr ratio of 1/2 were investigated.The experimental results showed that the Sc and Zr additions to Al-Cu-Mg alloy could strongly inhibit recrystallization, refine grain size, impede the segregation of Cu element along the grain boundary and increase the spacing of grain boundary precipitates. In addition, adding Sc and Zr to Al-Cu-Mg alloy effectively restricts the corrosion mechanism conversion associated with Al2 Cu Mg particles, which resulted in the change of the cross-section morphology of inter-granular corrosion from an undercutting to an elliptical shape. The susceptibility to inter-granular corrosion was significantly decreased with increasing Sc and Zr additions to the Al-Cu-Mg alloy. The relationships between microstructures evolution and inter-granular corrosion mechanism of Al-Cu-Mg-Sc-Zr alloys were also discussed. 展开更多
关键词 Aluminum alloy Microstructure SCANDIUM Inter-granular corrosion
原文传递
上一页 1 下一页 到第
使用帮助 返回顶部