Pedalium murex Linn(Pedaliaceae) fruits:a comparative antioxidant activity of its different fractions

Objective:To examine the antioxidant activity and total phenolic content of different solvent fractions of Pedulium murex(P.murex)Linn fruits(Family:Pedaliaceae)as well as the correlation between the total antioxidant capacity and total phenolic content.Methods:In the present study,the antioxidant activities of P.murex were evaluated using six in-vitro assays,namely total antioxidant assay,DPPH assay,reducing power,nitric oxide scavenging,hydrogen peroxide scavenging and deoxyribose scavenging assays,and total phenol contents were also investigated.Results:The ethyl acetate(EA)fraction was found to have high levels of phenolic content(298.72±2.09 mg GAE/g).The EA fraction exhibit higher total antioxidant capacity,higher percentage of DPPH radical scavenging activity(135.11±2.95μg/mL),nitric oxide(200.57±4.5lμg/mL),hydrogen peroxide(2I7.91±6.12μg/mL),deoxyribose(250.01±4.68μg/mL)and higher reducing power.Correlation coefficient(r^2=0.914)was found to be significant between total phenolic content and total antioxidant activity.Conclusions:In general,the results indicate that the EA fractions are rich in phenolic antioxidants with potent free radical scavenging activity implying their importance to human health.

Synthesis and evaluation of novel analogues of mangiferin as potent antipyretic

Objective:To screen different analogues of mangiferin pharmacologically for antipyretic activity. Methods:The naturally occurring xanthone glycoside mangiferin was isolated by column chromatography from the elhanolic extract of stem bark of Mangifera indica.Mangiferin was further converted to 5-(N-phenylamino methyleno) mangiferin.5-(N-p-chlorophenylamino methyleno) mangiferin,5-(N-2-methyl phenylamino methyleno) mangiferin.5-(N-p-methoxy phenylamino methyleno) mangiferin.5-(N,N-diphenylamino methyleno) mangiferin,5-(N-α-napthylamino methyleno) mangiferin and 5-(N-4-methyl phenylamino methyleno) mangiferin analogues.The synthesized compounds were further screened for antipyretic activity along with mangiferin at a dose level of 100 and 200 tng/kg.Mangiferin and its analogues were characterized by melting point and R_f value determination and through spectral technique like UV,IR,and NMR spectral analysis.Results:The antipyretic activity of mangiferin as well as all analogues was found to be more significant in at higher dose ie.200 mg/kg which was depicted thmugh a decrease in rectal temperature up to 3 h.Conclusions:The antipyretic activity of mangiferin and its analogues may be attributed to inhibition in synthesis of TNF-αand anti-oxidant activity associated with amelioration of inflammatory actions of cytokines.

Implications of Cytogenetic Abnormalities and Azoospermia Factor Microdeletions in Assisted Procreation

Assisted procreation techniques have revolutionized the management of infertility and have offered hope to millions of infertile couples. The main aim of these procedures is to produce healthy offspring. However recent studies on short term outcome of ART have reported a higher incidence of low birth weight, development delay, imprinting defects, sex and autosomal structural abnormalities, major and minor congenital malformation and certain cancers in babies conceived via ART. Further the health of ART conceived children beyond the neonatal period have been less well evaluated. A large number of infertile couples opting for ART have an underlying genetic aetiology. These genetic aberrations are iatrogenitically transmitted via ART. Thus it is important that all couples undergo a detailed and comprehensive genetic evaluation prior to ART.

用变压吸附法分离混合物组份生产两种高纯气

变压吸附(PSA)工艺传统上用于由混合气生产一种高纯气。由各种不同气比如甲烷蒸汽重整炉(SMR)出口气生产超高纯氢,是该技术最普通的用途之一。许多这类气含有相当高浓度的第二种气体,即SMR出口气中的二氧化碳,因此,回收主产品的同时也能回收副产品,这是非常有希望的。为达此目的,空气产品和化学品公司已开发出新的PSA工艺——GEMINI—8。本文通过甲烷蒸汽重整炉出口气的蒸馏生产氢和二氧化碳的过程,说明GEMINI—8PSA工艺的循环步骤,并讨论该工艺节省投资和电力以及同以前的技术相比的其它优点。

Poverty alleviation and resource conservation through development of cost effective technology at foot hill of Shivalik - A case study

The study revealed the development of cost effective technology utilized as a practical tool for treatment of seasonal torrent and addressing erosion problems and land use planning.Technology was implemented in a small agricultural watershed located in foot hill of Shivalik,India,to assess its prediction capacity of runoff,peak runoff flow and sediment yield.Cost effective technology was evaluated at the event scale by using a database of hydrological,geomorphologic and land use data collected during a two-year period.In the catchment,the gullies which are small to medium in size were treated with gully plugging by erecting loose boulder check dams and erected with different species of plants.Different types of spur were constructed with vegetative reinforcement for channelization of stream flow.The sediments deposited in the first year at downstream was recorded 0.09-81.0 tons,while in the second year it was reduced up to 0.07-16.7 tons.Similarly,up stream sediment deposition was recorded 1.0-72.0 tons and 0.37-13.1 tons in two consecutive years.The D-50 analysis of sediment deposited was carried in three different places of torrent and it was found that deposited particle size material decreased after treatment undertaken in the torrent bed.Therefore,the mechanical as well as vegetative measures helped in the channelization of water course towards the central line with the tune of 10-100 m,stabilization of torrent bed and reclamation of degraded land.