Over the past two decades, the CICECO-hub scientists have devoted substantial efforts to advancing bioactiveinorganic materials based on calcium phosphates and alkali-free bioactive glasses. A key focus has been thede...Over the past two decades, the CICECO-hub scientists have devoted substantial efforts to advancing bioactiveinorganic materials based on calcium phosphates and alkali-free bioactive glasses. A key focus has been thedeliberate incorporation of therapeutic ions like Mg, Sr, Zn, Mn, or Ga to enhance osteointegration and vascularization,confer antioxidant properties, and impart antimicrobial effects, marking significant contributions tothe field of biomaterials and bone tissue engineering. Such an approach is expected to circumvent the uncertaintiesposed by methods relying on growth factors, such as bone morphogenetic proteins, parathyroidhormone, and platelet-rich plasma, along with their associated high costs and potential adverse side effects. Thiscomprehensive overview of CICECO-hub’s significant contributions to the forefront inorganic biomaterials acrossall research aspects and dimensionalities (powders, granules, thin films, bulk materials, and porous structures),follows a unified approach rooted in a cohesive conceptual framework, including synthesis, characterization, andtesting protocols. Tangible outcomes [injectable cements, durable implant coatings, and bone graft substitutes(scaffolds) featuring customized porous architectures for implant fixation, osteointegration, accelerated boneregeneration in critical-sized bone defects] were achieved. The manuscript showcases specific biofunctionalexamples of successful biomedical applications and effective translations to the market of bone grafts foradvanced therapies.展开更多
基金the project No.2021/43/P/ST7/02418 cofunded by the National Science Centre and the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 945339JMFF,RB,PG gratefully acknowledge the financial support provided by the Polish National Science Centre for the POLONEZ BIS 1“BAGBONE”,Project no.536651. JMFF would like to thank all the national and international research collaborators for their valuable contributions,especially for the papers covered in this review article+2 种基金the scope of the project CICECOAveiro Institute of Materials,UIDB/50011/2020,UIDP/50011/2020&LA/P/0006/2020,financed by national funds through the FCT/MCTES(PIDDAC)the Department of Health Research–Indian Council of Medical Research[DHR-ICMR]India[Reference:R. 11013/28/2021-GIA/HR dated November 25,2021]is recognized by SK and MA. GES and ACP are thankful to the Core Program of the National Institute of Materials Physics within the National Research Development and Innovation Plan 2022–2027,carried out with the support of the Romanian Ministry of Research,Innovation and Digitalization under the project PC2-PN23080101.
文摘Over the past two decades, the CICECO-hub scientists have devoted substantial efforts to advancing bioactiveinorganic materials based on calcium phosphates and alkali-free bioactive glasses. A key focus has been thedeliberate incorporation of therapeutic ions like Mg, Sr, Zn, Mn, or Ga to enhance osteointegration and vascularization,confer antioxidant properties, and impart antimicrobial effects, marking significant contributions tothe field of biomaterials and bone tissue engineering. Such an approach is expected to circumvent the uncertaintiesposed by methods relying on growth factors, such as bone morphogenetic proteins, parathyroidhormone, and platelet-rich plasma, along with their associated high costs and potential adverse side effects. Thiscomprehensive overview of CICECO-hub’s significant contributions to the forefront inorganic biomaterials acrossall research aspects and dimensionalities (powders, granules, thin films, bulk materials, and porous structures),follows a unified approach rooted in a cohesive conceptual framework, including synthesis, characterization, andtesting protocols. Tangible outcomes [injectable cements, durable implant coatings, and bone graft substitutes(scaffolds) featuring customized porous architectures for implant fixation, osteointegration, accelerated boneregeneration in critical-sized bone defects] were achieved. The manuscript showcases specific biofunctionalexamples of successful biomedical applications and effective translations to the market of bone grafts foradvanced therapies.
