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类风湿病中左心室收缩功能障碍:一种未被认识的负荷?
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作者 Bhatia G.S. Sosin M.D. +2 位作者 Patel J.V. r.c. davis 孙凯 《世界核心医学期刊文摘(心脏病学分册)》 2006年第8期58-59,共2页
OBJECTIVES: This study sought to ascertain whether left ventricular systolic dysfunction(LVSD) is more common among clinic patients with rheumatoid disease(RD) compared with the general population, and to assess the d... OBJECTIVES: This study sought to ascertain whether left ventricular systolic dysfunction(LVSD) is more common among clinic patients with rheumatoid disease(RD) compared with the general population, and to assess the diagnostic utility of brain natriuretic peptide(BNP). BACKGROUND:Patients with RD are at increased risk of ischemic heart disease. However, there are few large echocardiographic studies identifying cardiac dysfunction in RD. We hypothesized that LVSD would be more prevalent in RD patients than in the general population. METHODS: A total of 226 hospital out-patients with RD(65% women) underwent clinical evaluation, electrocardiography(ECG), echocardiography, and plasma BNP assay(218 patients). Prevalence of LVSD was compared with local population estimates. RESULTS: Definite LVSD(left ventricular ejection fraction< 40% ) occurred in 5.3% of the RD group: standardized prevalence ratio,3.20; 95% confidence interval, 1.65 to 5.59. Median BNP values were higher in patients with LVSD compared with those without: 16.6 pmol/l versus 8.5 pmol/l, p< 0.005, although values between the two groups overlapped. One in nine patients with an abnormal ECG had definite LVSD. CONCLUSIONS: Definite LVSD was three times more common in RD patients than in the general population. Given the prognostic benefits of treating LVSD, echocardiographic screening of RD patients with an abnormal ECG may be worthwhile. 展开更多
关键词 左心室收缩功能障碍 类风湿病 脑利钠肽(BNP) 超声心动图检查 ECG异常 正常人群 负荷 缺血性心脏病 左室射血分数
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