In total knee arthroplasty(TKA)and total hip replacement(THR)the restoration of the normal joint function represents a fundamental feature.A prosthetic joint must be able to provide motions and to transmit functional ...In total knee arthroplasty(TKA)and total hip replacement(THR)the restoration of the normal joint function represents a fundamental feature.A prosthetic joint must be able to provide motions and to transmit functional loads.As reported in the literature,the stress distribution may be altered in bones after the implantation of a total joint prosthesis.Some scientific works have also correlated uncemented TKA to a progressive decrease of bone density below the tibial component.Antibiotic-loaded bone cements are commonly employed in conjunction with systemic antibiotics to treat infections.Furthermore,nanoparticles with antimicrobial activity have been widely analysed.Accordingly,the current research was focused on a preliminary analysis of the mechanical and antibacterial activity of a PMMA-based bone cement loaded with gold nanoparticles.The obtained results demonstrated that nanocomposite cements with a specific concentration of gold nanoparticles improved the punching performance and antibacterial activity.However,critical aspects were found in the optimization of the nanocomposite bone cement.展开更多
The limited number of resins,available for stereolithography applications,is one of the key drivers in research applied to rapid prototyping.In this work an acrylic photocrosslinkable resin based on methyl methacrylat...The limited number of resins,available for stereolithography applications,is one of the key drivers in research applied to rapid prototyping.In this work an acrylic photocrosslinkable resin based on methyl methacrylate(MMA),butyl methacrylate(BMA)and poly(ethylene glycol)dimethacrylate(PEGDA)was developed with different composition and characterized in terms of mechanical,thermal and biological behaviour.Two different systems have been developed using different amount of reagent.The influence of every components have been evaluated on the final characteristic of the resin in order to optimize the final composition for applications in bone tissue engineering.The crosslinked materials showed good mechanical properties and thermal stabilities and moreover cytotoxicity test confirms good biocompatibility with no cytotoxic effect on cells metabolism.Moreover two different treatments have been proposed,using fetal bovine serum(FBS)and methanol(MeOH),in order to improve cell recognition of the surfaces.Samples threatened with MeOH allow cell adhesion and survival,promoting spreading,elongation and fusion of C2C12 muscle myoblast cells.展开更多
文摘In total knee arthroplasty(TKA)and total hip replacement(THR)the restoration of the normal joint function represents a fundamental feature.A prosthetic joint must be able to provide motions and to transmit functional loads.As reported in the literature,the stress distribution may be altered in bones after the implantation of a total joint prosthesis.Some scientific works have also correlated uncemented TKA to a progressive decrease of bone density below the tibial component.Antibiotic-loaded bone cements are commonly employed in conjunction with systemic antibiotics to treat infections.Furthermore,nanoparticles with antimicrobial activity have been widely analysed.Accordingly,the current research was focused on a preliminary analysis of the mechanical and antibacterial activity of a PMMA-based bone cement loaded with gold nanoparticles.The obtained results demonstrated that nanocomposite cements with a specific concentration of gold nanoparticles improved the punching performance and antibacterial activity.However,critical aspects were found in the optimization of the nanocomposite bone cement.
文摘The limited number of resins,available for stereolithography applications,is one of the key drivers in research applied to rapid prototyping.In this work an acrylic photocrosslinkable resin based on methyl methacrylate(MMA),butyl methacrylate(BMA)and poly(ethylene glycol)dimethacrylate(PEGDA)was developed with different composition and characterized in terms of mechanical,thermal and biological behaviour.Two different systems have been developed using different amount of reagent.The influence of every components have been evaluated on the final characteristic of the resin in order to optimize the final composition for applications in bone tissue engineering.The crosslinked materials showed good mechanical properties and thermal stabilities and moreover cytotoxicity test confirms good biocompatibility with no cytotoxic effect on cells metabolism.Moreover two different treatments have been proposed,using fetal bovine serum(FBS)and methanol(MeOH),in order to improve cell recognition of the surfaces.Samples threatened with MeOH allow cell adhesion and survival,promoting spreading,elongation and fusion of C2C12 muscle myoblast cells.
