It has been recognized that physical and chemical properties of biomaterial surfaces mediate the quality of extracellular matrix(ECM)that may affect cell behaviors.In nature,ECM is a heterogeneous three-dimensional su...It has been recognized that physical and chemical properties of biomaterial surfaces mediate the quality of extracellular matrix(ECM)that may affect cell behaviors.In nature,ECM is a heterogeneous three-dimensional superstructure formed by three major components,glycosaminoglycan,glycoconjugate,and protein,that anchors cellular compartments in tissues and regulates the function and the behavior of cells.Changes in the biointerface alter the quality of ECM and morphology through cell surface receptors,which,in turn,enable it to trigger specific cell signaling and different cellular responses.In fact,a number of strategies have been used to improve the functionality of surfaces and direct cell behavior through precisely designed environments.Herein,we aimed to discuss,through a science-based viewpoint,the biomaterial surface features on cell behavior and analyze the impact of cell physical modification on dental implant development.展开更多
The periodontium comprises all structures surrounding the teeth,including gingiva,root cementum,periodontal ligament and alveolar bone.Those tissues aim to protect and support the teeth and are challenged by a residin...The periodontium comprises all structures surrounding the teeth,including gingiva,root cementum,periodontal ligament and alveolar bone.Those tissues aim to protect and support the teeth and are challenged by a residing microbiota that leads to subclinical inflammation even in physiological conditions.Periodontitis,a prevalent multicausal inflammatory and destructive disease,develops as a result from complex host-parasite interactions.This unique physiologic and pathologic scenario enables the development of research methods which allows conclusions beyond the simple understanding of periodontal homeostasis.The aim of this viewpoint was to explore potential contributions of periodontal research to a wide array of basic science specialties,such as cell and molecular biology,microbiology,immunology,endocrinology,rheumatology,among others.展开更多
基金Pereira MMA is currently supported by grant provided by Coordination for the Improvement of Higher Education Personnel(CAPES#88887.573209/2020-00)finance code 001de Molon RS was supported by grant provided by CAPES(Coordenação de Aperfeiçoamento de Pessoal de Nível Superior)Grant#88887.583248/2020-00de Avila ED was supported by grant provided by FAPESP(The São Paulo Research Foundation)grant#2018/20719-3.
文摘It has been recognized that physical and chemical properties of biomaterial surfaces mediate the quality of extracellular matrix(ECM)that may affect cell behaviors.In nature,ECM is a heterogeneous three-dimensional superstructure formed by three major components,glycosaminoglycan,glycoconjugate,and protein,that anchors cellular compartments in tissues and regulates the function and the behavior of cells.Changes in the biointerface alter the quality of ECM and morphology through cell surface receptors,which,in turn,enable it to trigger specific cell signaling and different cellular responses.In fact,a number of strategies have been used to improve the functionality of surfaces and direct cell behavior through precisely designed environments.Herein,we aimed to discuss,through a science-based viewpoint,the biomaterial surface features on cell behavior and analyze the impact of cell physical modification on dental implant development.
基金de Molon RS was supported by grant provided by CAPES(Coordenação de Aperfeiçoamento de Pessoal de Nível Superior)Grant#88887.583248/2020-00.
文摘The periodontium comprises all structures surrounding the teeth,including gingiva,root cementum,periodontal ligament and alveolar bone.Those tissues aim to protect and support the teeth and are challenged by a residing microbiota that leads to subclinical inflammation even in physiological conditions.Periodontitis,a prevalent multicausal inflammatory and destructive disease,develops as a result from complex host-parasite interactions.This unique physiologic and pathologic scenario enables the development of research methods which allows conclusions beyond the simple understanding of periodontal homeostasis.The aim of this viewpoint was to explore potential contributions of periodontal research to a wide array of basic science specialties,such as cell and molecular biology,microbiology,immunology,endocrinology,rheumatology,among others.
