Government credibility is an important asset of contemporary national governance, an important criterion for evaluating government legitimacy, and a key factor in measuring the effectiveness of government governance. ...Government credibility is an important asset of contemporary national governance, an important criterion for evaluating government legitimacy, and a key factor in measuring the effectiveness of government governance. In recent years, researchers’ research on government credibility has mostly focused on exploring theories and mechanisms, with little empirical research on this topic. This article intends to apply variable selection models in the field of social statistics to the issue of government credibility, in order to achieve empirical research on government credibility and explore its core influencing factors from a statistical perspective. Specifically, this article intends to use four regression-analysis-based methods and three random-forest-based methods to study the influencing factors of government credibility in various provinces in China, and compare the performance of these seven variable selection methods in different dimensions. The research results show that there are certain differences in simplicity, accuracy, and variable importance ranking among different variable selection methods, which present different importance in the study of government credibility issues. This study provides a methodological reference for variable selection models in the field of social science research, and also offers a multidimensional comparative perspective for analyzing the influencing factors of government credibility.展开更多
Host genes involved in lipid metabolism are differentially affected during the early stages of hepatitis C virus （HCV） infection. Here we demonstrate that artificial up-regulation of fatty acid biosynthesis has a po...Host genes involved in lipid metabolism are differentially affected during the early stages of hepatitis C virus （HCV） infection. Here we demonstrate that artificial up-regulation of fatty acid biosynthesis has a positive effect on the replication of the HCV full-length replicon when cells were treated with nystatin. Conversely, the HCV RNA replication was decreased when fatty acid biosynthesis was inhibited with 25-hydroxycholesterol and PDMP（D-threo-l-phenyl-2-decanoylamino-3- morpholino-l-propanol）. In agreement with these results, the expression level of GlcT-l（ceramide glucosyltransferase）, a host glucosyltransferase in the first step of GSL （glycosphingolipid） biosynthesis, was found to be closely associated with the expression and replication of HCV RNA. On the other hand, the viral RNA can also activate GlcT-1 in the early stage of viral RNA transfection in vitro. To identify viral factors that are responsible for GlcT-1 activation, we constructed ten stable Vero cell lines that express individual HCV proteins. Based on the analyses of these cell lines and transient transfection assay of the GlcT-1 promoter regions, we conclude that HCV proteins, especially NS5A and NS5B, have positive effects on the expression of GlcT-1. It is possible that NS5A and NS5B stimulate transcription factor（s） to activate the expression of GlcT-1 by increasing its transcription level展开更多
1.Introduction Maritime transport is the backbone of international trade.The amount of total international maritime trade in million tonnes loaded was 8408 in 2012 and had increased to 11076 by 2019,for an average ann...1.Introduction Maritime transport is the backbone of international trade.The amount of total international maritime trade in million tonnes loaded was 8408 in 2012 and had increased to 11076 by 2019,for an average annual increase of 3.12%.In early 2020,the world fleet contained 98140 ships of 100 gross tonnes and above with 2.06 million dead weight tonnage of capacity[1].The greenhouse gas(GHG)emissions from shipping activities are not negligible.According to the fourth GHG study commissioned by the International Maritime Organization(IMO),in 2018,global shipping emitted a total of 1056 million tonnes of carbon dioxide(CO_(2)),accounting for around 2.89%of global anthropogenic CO_(2) emissions[2].Due to the international nature of shipping,efforts to control CO_(2) emissions from ships are absent from the Kyoto Protocol and the Paris Agreement.In an attempt to phase out carbon emissions from shipping entirely,the IMO formulated a strategy to cut the total annual GHG emissions from shipping by at least 50%from their 2008 levels by 2050[3];however,no mandatory rules have been promulgated since the release of this strategy.展开更多
文摘Government credibility is an important asset of contemporary national governance, an important criterion for evaluating government legitimacy, and a key factor in measuring the effectiveness of government governance. In recent years, researchers’ research on government credibility has mostly focused on exploring theories and mechanisms, with little empirical research on this topic. This article intends to apply variable selection models in the field of social statistics to the issue of government credibility, in order to achieve empirical research on government credibility and explore its core influencing factors from a statistical perspective. Specifically, this article intends to use four regression-analysis-based methods and three random-forest-based methods to study the influencing factors of government credibility in various provinces in China, and compare the performance of these seven variable selection methods in different dimensions. The research results show that there are certain differences in simplicity, accuracy, and variable importance ranking among different variable selection methods, which present different importance in the study of government credibility issues. This study provides a methodological reference for variable selection models in the field of social science research, and also offers a multidimensional comparative perspective for analyzing the influencing factors of government credibility.
基金the National"973"Program of China(No.2011CB504800)
文摘Host genes involved in lipid metabolism are differentially affected during the early stages of hepatitis C virus （HCV） infection. Here we demonstrate that artificial up-regulation of fatty acid biosynthesis has a positive effect on the replication of the HCV full-length replicon when cells were treated with nystatin. Conversely, the HCV RNA replication was decreased when fatty acid biosynthesis was inhibited with 25-hydroxycholesterol and PDMP（D-threo-l-phenyl-2-decanoylamino-3- morpholino-l-propanol）. In agreement with these results, the expression level of GlcT-l（ceramide glucosyltransferase）, a host glucosyltransferase in the first step of GSL （glycosphingolipid） biosynthesis, was found to be closely associated with the expression and replication of HCV RNA. On the other hand, the viral RNA can also activate GlcT-1 in the early stage of viral RNA transfection in vitro. To identify viral factors that are responsible for GlcT-1 activation, we constructed ten stable Vero cell lines that express individual HCV proteins. Based on the analyses of these cell lines and transient transfection assay of the GlcT-1 promoter regions, we conclude that HCV proteins, especially NS5A and NS5B, have positive effects on the expression of GlcT-1. It is possible that NS5A and NS5B stimulate transcription factor（s） to activate the expression of GlcT-1 by increasing its transcription level
基金This research is supported by the National Natural Science Foundation of China(72071173,71831008,and 72025103).
文摘1.Introduction Maritime transport is the backbone of international trade.The amount of total international maritime trade in million tonnes loaded was 8408 in 2012 and had increased to 11076 by 2019,for an average annual increase of 3.12%.In early 2020,the world fleet contained 98140 ships of 100 gross tonnes and above with 2.06 million dead weight tonnage of capacity[1].The greenhouse gas(GHG)emissions from shipping activities are not negligible.According to the fourth GHG study commissioned by the International Maritime Organization(IMO),in 2018,global shipping emitted a total of 1056 million tonnes of carbon dioxide(CO_(2)),accounting for around 2.89%of global anthropogenic CO_(2) emissions[2].Due to the international nature of shipping,efforts to control CO_(2) emissions from ships are absent from the Kyoto Protocol and the Paris Agreement.In an attempt to phase out carbon emissions from shipping entirely,the IMO formulated a strategy to cut the total annual GHG emissions from shipping by at least 50%from their 2008 levels by 2050[3];however,no mandatory rules have been promulgated since the release of this strategy.
