国际社会认识到慢性肾脏病(chronic kidney disease,CKD)已经是全球范围内严重的公共卫生问题,对CKD的防治存在诸多不足,如果得不到改进可能会影响到全球可持续的发展[1]。除了加强CKD监测,提高对CKD自然病程的认识,建立更好的CKD诊断方...国际社会认识到慢性肾脏病(chronic kidney disease,CKD)已经是全球范围内严重的公共卫生问题,对CKD的防治存在诸多不足,如果得不到改进可能会影响到全球可持续的发展[1]。除了加强CKD监测,提高对CKD自然病程的认识,建立更好的CKD诊断方法,处理CKD的主要危险因素外,还需要评估现行的CKD治疗方案对临床结局的影响,同时强调改善CKD症状和并发症的处理措施。现阶段,开发新的干预措施已经是现实的任务。国际肾脏病学会(International Society of Nephrology, ISN)特别指出CKD的防治需要根据地理、社会经济、文化等诸多因素进行调整,在全球范围内改进CKD防治的数据收集、科研方法和防治策略。展开更多
Chronic kidney disease(CKD) is a clinical syndrome with a series of clinical manifestations and metabolic disorders caused by many diseases, which are characterized by progressive deterioration or irreversible damage ...Chronic kidney disease(CKD) is a clinical syndrome with a series of clinical manifestations and metabolic disorders caused by many diseases, which are characterized by progressive deterioration or irreversible damage of renal structures and functions. With the progress of epidemiological research, CKD has brought about huge economic and psychological burdens. There is a considerable risk of cardiovascular events or death than progression to end-stage renal disease for patients. Particular attentions should be paid to the new goals of reducing cardiovascular events and all-cause mortality. It is important to analyze the etiology and pathogenesis according to patients' ages, regions, primary disease as well as different stages of disease, and choose the appropriate therapeutic strategies accordingly. In clinical practice, due to the uncertainty of therapeutic effects ofmodern medicine based on the risk factors, it is necessary to use Chinese medicine(CM) to delay the disease progression and reduce comorbidities. Turbid toxin and blood stasis are two critical pathological factors worthy of concerns in the theory of CM. In addition, appropriate use of CM may help improve the quality of life of patients with CKD.展开更多
Chronic kidney disease （CKD） is a major disease that threatens human health. With the progression of CKD, the risk of cardiovascular death increases, which is associated with the elevated levels of uremic toxins （...Chronic kidney disease （CKD） is a major disease that threatens human health. With the progression of CKD, the risk of cardiovascular death increases, which is associated with the elevated levels of uremic toxins （UTs）. Representative toxins such as indoxyl sulfate and p-cresyl sulfate are involed in CKD progression and cardiovascular events inseparable from the key role of endothelial dysfunction. The therapeutic strategies of UTs are aimed at signaling pathways that target the levels and damage of toxins in modem medicine. There is a certain relevance between toxins and ＂turbid toxin＂ in the theory of Chinese medicine （CM）. CM treatments have been demonstrated to reduce the damage of gut-derived toxins to the heart, kidney and blood vessels. Modern medicine still lacks evidence-based therapies, so it is necessary to explore the treatments of CM.展开更多
Monoclonal gammopathy of renal significance(MGRS)is a pathological state which presents with a spectrum of renal lesions.MGRS is characterized by pathogenic monoclonal immunoglobulins or light chains produced by a pre...Monoclonal gammopathy of renal significance(MGRS)is a pathological state which presents with a spectrum of renal lesions.MGRS is characterized by pathogenic monoclonal immunoglobulins or light chains produced by a premalignant plasma cell or B cell clone.In view of inadequate understanding in the past,the low detection rate of MGRS often results in poor outcomes and reduces quality of life of patients.Thus,MGRS stands for a group of clinical refractory renal diseases.To date,no standard treatment strategy for MGRS is available.Current consensus suggests a clone-directed approach that aims to eradicate the offending clone,but its long-term prognosis is not clear.In this article,we discuss the diagnostic methods,highlight treatment advances,and introduce integrated Chinese and Western medicine in the management of MGRS.展开更多
文摘国际社会认识到慢性肾脏病(chronic kidney disease,CKD)已经是全球范围内严重的公共卫生问题,对CKD的防治存在诸多不足,如果得不到改进可能会影响到全球可持续的发展[1]。除了加强CKD监测,提高对CKD自然病程的认识,建立更好的CKD诊断方法,处理CKD的主要危险因素外,还需要评估现行的CKD治疗方案对临床结局的影响,同时强调改善CKD症状和并发症的处理措施。现阶段,开发新的干预措施已经是现实的任务。国际肾脏病学会(International Society of Nephrology, ISN)特别指出CKD的防治需要根据地理、社会经济、文化等诸多因素进行调整,在全球范围内改进CKD防治的数据收集、科研方法和防治策略。
基金Supported by the National Natural Science Foundation of China(No.81573791,81141122)Special Research Project in Chinese Medicine Industry(No.201407001)
文摘Chronic kidney disease(CKD) is a clinical syndrome with a series of clinical manifestations and metabolic disorders caused by many diseases, which are characterized by progressive deterioration or irreversible damage of renal structures and functions. With the progress of epidemiological research, CKD has brought about huge economic and psychological burdens. There is a considerable risk of cardiovascular events or death than progression to end-stage renal disease for patients. Particular attentions should be paid to the new goals of reducing cardiovascular events and all-cause mortality. It is important to analyze the etiology and pathogenesis according to patients' ages, regions, primary disease as well as different stages of disease, and choose the appropriate therapeutic strategies accordingly. In clinical practice, due to the uncertainty of therapeutic effects ofmodern medicine based on the risk factors, it is necessary to use Chinese medicine(CM) to delay the disease progression and reduce comorbidities. Turbid toxin and blood stasis are two critical pathological factors worthy of concerns in the theory of CM. In addition, appropriate use of CM may help improve the quality of life of patients with CKD.
基金Supported by the National Natural Science Foundation of China(No.81573791,81141122)
文摘Chronic kidney disease （CKD） is a major disease that threatens human health. With the progression of CKD, the risk of cardiovascular death increases, which is associated with the elevated levels of uremic toxins （UTs）. Representative toxins such as indoxyl sulfate and p-cresyl sulfate are involed in CKD progression and cardiovascular events inseparable from the key role of endothelial dysfunction. The therapeutic strategies of UTs are aimed at signaling pathways that target the levels and damage of toxins in modem medicine. There is a certain relevance between toxins and ＂turbid toxin＂ in the theory of Chinese medicine （CM）. CM treatments have been demonstrated to reduce the damage of gut-derived toxins to the heart, kidney and blood vessels. Modern medicine still lacks evidence-based therapies, so it is necessary to explore the treatments of CM.
文摘Monoclonal gammopathy of renal significance(MGRS)is a pathological state which presents with a spectrum of renal lesions.MGRS is characterized by pathogenic monoclonal immunoglobulins or light chains produced by a premalignant plasma cell or B cell clone.In view of inadequate understanding in the past,the low detection rate of MGRS often results in poor outcomes and reduces quality of life of patients.Thus,MGRS stands for a group of clinical refractory renal diseases.To date,no standard treatment strategy for MGRS is available.Current consensus suggests a clone-directed approach that aims to eradicate the offending clone,but its long-term prognosis is not clear.In this article,we discuss the diagnostic methods,highlight treatment advances,and introduce integrated Chinese and Western medicine in the management of MGRS.
