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Xp11.2易位/TFE3基因融合相关性肾癌的CT及18F-FDG PET/CT表现与鉴别诊断 被引量:8
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作者 朱虹静 任方远 +3 位作者 赵帅 茅娟丽 董爱生 左长京 《中国医学计算机成像杂志》 CSCD 北大核心 2019年第6期581-585,共5页
目的:探讨增强CT及18F-FDG PET/CT检査在Xp11.2易位/TFE3基因融合相关性肾癌(Xp11.2易位性肾癌)的诊断以及与乳头状肾癌的鉴别诊断中的价值。方法:回顾性分析经手术病理证实的42例Xp11.2易位性肾癌和90例乳头状肾癌病例,所有患者治疗前... 目的:探讨增强CT及18F-FDG PET/CT检査在Xp11.2易位/TFE3基因融合相关性肾癌(Xp11.2易位性肾癌)的诊断以及与乳头状肾癌的鉴别诊断中的价值。方法:回顾性分析经手术病理证实的42例Xp11.2易位性肾癌和90例乳头状肾癌病例,所有患者治疗前均行肾脏平扫及增强CT和/或PET/CT检查,分析并比较两组肾癌人口学资料以及CT、PET/CT表现。结果:与乳头状肾癌相比,Xp11.2易位性肾癌发病年龄较轻(P<0.001),最大径较大(P<0.001),肿瘤内部更易出现囊变坏死(P<0.001)。Xp11.2易位性肾癌钙化发生率高于乳头状肾癌(P<0.05),且CT平扫密度高于后者(P<0.05);增强后Xp11.2易位性肾癌强化程度高于乳头状肾癌,前者皮髓质期、实质期、延迟期肿瘤强化值及皮髓质期相对平扫CT值增强量均较高(P均<0.05),且增强扫描后前者更常见走形扭曲的瘤内及瘤周新生血管(P均<0.05)。Xp11.2易位性肾癌远处转移或邻近器官侵犯发生率高于乳头状肾癌(P<0.05)。5例Xp11.2易位性肾癌和9例乳头状肾癌PET/CT均呈FDG高代谢,前者5例均合并肾静脉侵犯或转移,后者3例合并肾静脉侵犯或转移。结论:Xp11.2易位性肾癌的增强CT表现有一定的特征性,结合患者临床特点,有助于与乳头状肾癌的鉴别诊断,而18F-FDG PET/CT可为其定性诊断和分期提供更多信息。 展开更多
关键词 肾癌 Xp11.2易位 体层摄影术 X线计算机 正电子发射断层显像
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乙型肝炎肝硬化患者血浆硒浓度与肝功能相关指标、甲胎蛋白、癌胚抗原的相关性 被引量:5
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作者 葛舰 王祖君 +3 位作者 任方元 段俊 赵蕾 李小丹 《广西医学》 CAS 2020年第3期351-352,359,共3页
目的探讨乙型肝炎肝硬化患者血浆硒浓度与肝功能相关指标、甲胎蛋白、癌胚抗原的相关性。方法选取60例乙型肝炎肝硬化患者,检测其血浆硒浓度及血清甲胎蛋白、癌胚抗原、ALT、总胆红素、白蛋白、球蛋白、凝血酶原时间、血氨水平,比较Chil... 目的探讨乙型肝炎肝硬化患者血浆硒浓度与肝功能相关指标、甲胎蛋白、癌胚抗原的相关性。方法选取60例乙型肝炎肝硬化患者,检测其血浆硒浓度及血清甲胎蛋白、癌胚抗原、ALT、总胆红素、白蛋白、球蛋白、凝血酶原时间、血氨水平,比较Child-Pugh A、B、C级患者血浆硒浓度,分析血浆硒浓度与血清甲胎蛋白、癌胚抗原、ALT、总胆红素、白蛋白、球蛋白、凝血酶原时间、血氨的相关性。结果Child-Pugh A、B、C级患者血浆硒浓度差异有统计学意义(P<0.05),失代偿期患者血浆硒浓度低于代偿期。乙型肝炎肝硬化患者血浆硒浓度与甲胎蛋白、ALT呈负相关,与白蛋白呈正相关(P<0.05)。结论乙型肝炎肝硬化患者血浆硒浓度可在一定程度上反映肝脏储备功能,补硒有可能改善肝功能。 展开更多
关键词 乙型肝炎 肝硬化 血浆硒 甲胎蛋白 癌胚抗原 肝功能
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CT features of colloid carcinomas of the pancreas 被引量:4
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作者 ren fang-yuan SHAO Cheng-wei +1 位作者 ZUO Chang-jing LU Jian-ping 《Chinese Medical Journal》 SCIE CAS CSCD 2010年第10期1329-1332,共4页
Background Colloid carcinomas of the pancreas have better prognosis than ordinary ductal adenocarcinoma, and preoperative distinction of colloid carcinoma from other pancreatic tumors is valuable for patient therapeut... Background Colloid carcinomas of the pancreas have better prognosis than ordinary ductal adenocarcinoma, and preoperative distinction of colloid carcinoma from other pancreatic tumors is valuable for patient therapeutic planning and prognosis assessment. However, data about CT features of colloid carcinoma are very limited. This study aimed to investigate the CT features of this tumor. Methods Institutional review board approval was obtained for this study. Seven patients with pathologically proven colloid carcinoma of the pancreas were included. Unenhanced and dynamic enhanced CT was performed in all the patients. CT features were analyzed retrospectively and correlations with pathological findings were evaluated. Results Mean age of the patients was 59.8 years (41-76 years). Five tumors were located in the pancreatic head, and the other two in body and tail respectively. The maximum mean diameter of the tumors on axial scanning was 3.9 cm (3.0-6.7 cm). Tumors were round (n=-5) and Iobular (n=2). Tumors appeared slight hyp-attenuation on unenhanced CT, and peripheral and internal meshlike progressive delayed enhancement with great percent of cystic areas on enhanced CT. Calcification and gas in the tumor was seen in one patient whose duodenum was invaded by the tumor. Conclusions Colloid carcinomas of the pancreas appear as round or labular masses with great percent of cystic areas and slight hyp-attenuation on unenhanced CT and peripheral and internal meshlike progressive delayed enhancement on enhanced CT. 展开更多
关键词 tomography X-ray computed colloid carcinoma PANCREAS
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