目的:观察通窍明目汤联合羟苯磺酸钙治疗糖尿病视网膜病变黄斑水肿(DME)的临床疗效,分析其对患者眼部症状及血清指标的改善效果。方法:选择80例(80眼)DME患者为研究对象,通过盲选法随机分为对照组与联合组各40例。2组均接受激光治疗,对...目的:观察通窍明目汤联合羟苯磺酸钙治疗糖尿病视网膜病变黄斑水肿(DME)的临床疗效,分析其对患者眼部症状及血清指标的改善效果。方法:选择80例(80眼)DME患者为研究对象,通过盲选法随机分为对照组与联合组各40例。2组均接受激光治疗,对照组辅助羟苯磺酸钙治疗,联合组在对照组基础上联用通窍明目汤治疗,连续治疗3个月。比较2组临床疗效、用药安全性,并比较2组治疗前后眼部情况及血清指标。结果:联合组治疗总有效率为92.50%,高于对照组70.00%(P<0.05)。治疗前,2组最佳矫正视力、黄斑中心厚度与黄斑区荧光面积比较,差异无统计学意义(P>0.05);治疗后,2组最佳矫正视力均提高(P<0.05),黄斑中心厚度均变薄(P<0.05),黄斑区荧光面积均减小(P<0.05),且联合组最佳矫正视力高于对照组(P<0.05),黄斑中心厚度薄于对照组(P<0.05),黄斑区荧光面积小于对照组(P<0.05)。治疗前,2组血清一氧化氮合成酶(NOS)、脂联素(APN)、血管内皮生长因子(VEGF)、白细胞介素-6(IL-6)、同型半胱氨酸(Hcy)水平比较,差异无统计学意义(P>0.05);治疗后,2组血清NOS、APN水平均升高(P<0.05),且联合组高于对照组(P<0.05),2组VEGF、IL-6、Hcy水平均下降(P<0.05),且联合组低于对照组(P<0.05)。治疗期间,对照组与联合组眼压>21 mm Hg的患者分别为16例(40.00%)与6例(15.00%),2组比较,差异有统计学意义(χ2=6.270,P=0.012)。经处理后眼压均恢复正常。期间并未出现视网膜脱落、眼内炎、白内障等并发症情况。结论:通窍明目汤联合羟苯磺酸钙治疗DME患者,能够提高视力,减少黄斑中心厚度,其作用机制可能与抑制炎性反应及视网膜血管异常增生,改善眼底循环有关。展开更多
A novel membrane distillation concentration method was used m prepare high concentration polyaluminum chloride （PAC1） with high content of AID or Ale. 2.52 mol/L PACl1 with 88% Alb and 2.38 mol/L PACl2 with 61% Ale ...A novel membrane distillation concentration method was used m prepare high concentration polyaluminum chloride （PAC1） with high content of AID or Ale. 2.52 mol/L PACl1 with 88% Alb and 2.38 mol/L PACl2 with 61% Ale were successfully prepared. Three coagulants, AlCl3, PACl1 and PACl2 were investigated on their hydrolysis behavior and speciation under different conditions. The effects of pH and dilution ratio on Al species distribution were investigated by ferron assay. Experimental result showed that pH had a significant effect on Al species distribution for the three coagulants. Dilution ratio had little effects on Alb and Alc distribution in whole dilution process except the beginning for PACl1 and PACl2. The results indicated that transformation of Al depends largely on their original composition. AlCl3 was the most unstable coagulant among these three coagulants during hydrolysis process. PACl1 and PACl2 with significant amounts of highly charged and stable polynuclear aluminum hydrolysis products were less affected by the hydrolysis conditions and could maintain high speciation stability under various conditions.展开更多
文摘目的:观察通窍明目汤联合羟苯磺酸钙治疗糖尿病视网膜病变黄斑水肿(DME)的临床疗效,分析其对患者眼部症状及血清指标的改善效果。方法:选择80例(80眼)DME患者为研究对象,通过盲选法随机分为对照组与联合组各40例。2组均接受激光治疗,对照组辅助羟苯磺酸钙治疗,联合组在对照组基础上联用通窍明目汤治疗,连续治疗3个月。比较2组临床疗效、用药安全性,并比较2组治疗前后眼部情况及血清指标。结果:联合组治疗总有效率为92.50%,高于对照组70.00%(P<0.05)。治疗前,2组最佳矫正视力、黄斑中心厚度与黄斑区荧光面积比较,差异无统计学意义(P>0.05);治疗后,2组最佳矫正视力均提高(P<0.05),黄斑中心厚度均变薄(P<0.05),黄斑区荧光面积均减小(P<0.05),且联合组最佳矫正视力高于对照组(P<0.05),黄斑中心厚度薄于对照组(P<0.05),黄斑区荧光面积小于对照组(P<0.05)。治疗前,2组血清一氧化氮合成酶(NOS)、脂联素(APN)、血管内皮生长因子(VEGF)、白细胞介素-6(IL-6)、同型半胱氨酸(Hcy)水平比较,差异无统计学意义(P>0.05);治疗后,2组血清NOS、APN水平均升高(P<0.05),且联合组高于对照组(P<0.05),2组VEGF、IL-6、Hcy水平均下降(P<0.05),且联合组低于对照组(P<0.05)。治疗期间,对照组与联合组眼压>21 mm Hg的患者分别为16例(40.00%)与6例(15.00%),2组比较,差异有统计学意义(χ2=6.270,P=0.012)。经处理后眼压均恢复正常。期间并未出现视网膜脱落、眼内炎、白内障等并发症情况。结论:通窍明目汤联合羟苯磺酸钙治疗DME患者,能够提高视力,减少黄斑中心厚度,其作用机制可能与抑制炎性反应及视网膜血管异常增生,改善眼底循环有关。
基金supported by the National Natural Science Foundation of China (No 50708109, 20577061,40673003)the National Hi-Tech Research and Develop-ment Key Program (863) of China (No 2007AA06Z339)the Special Fund from the State Key Laboratory of Environmental Aquatic Chemistry (No 09Y02ESPCR,09Z01ESPCR)
文摘A novel membrane distillation concentration method was used m prepare high concentration polyaluminum chloride （PAC1） with high content of AID or Ale. 2.52 mol/L PACl1 with 88% Alb and 2.38 mol/L PACl2 with 61% Ale were successfully prepared. Three coagulants, AlCl3, PACl1 and PACl2 were investigated on their hydrolysis behavior and speciation under different conditions. The effects of pH and dilution ratio on Al species distribution were investigated by ferron assay. Experimental result showed that pH had a significant effect on Al species distribution for the three coagulants. Dilution ratio had little effects on Alb and Alc distribution in whole dilution process except the beginning for PACl1 and PACl2. The results indicated that transformation of Al depends largely on their original composition. AlCl3 was the most unstable coagulant among these three coagulants during hydrolysis process. PACl1 and PACl2 with significant amounts of highly charged and stable polynuclear aluminum hydrolysis products were less affected by the hydrolysis conditions and could maintain high speciation stability under various conditions.
