目的:系统评价桂枝茯苓胶囊(丸)联合曼月乐治疗子宫腺肌病的疗效和安全性。方法:运用计算机检索国家知识基础设施数据库、中国学术期刊数据库、中文科技期刊数据库、中国生物医学文献数据库、PubMed、The Cochrane Library、The Web of ...目的:系统评价桂枝茯苓胶囊(丸)联合曼月乐治疗子宫腺肌病的疗效和安全性。方法:运用计算机检索国家知识基础设施数据库、中国学术期刊数据库、中文科技期刊数据库、中国生物医学文献数据库、PubMed、The Cochrane Library、The Web of Science、Springer等中英文数据库从建库至2020年5月关于桂枝茯苓胶囊(丸)联合曼月乐治疗子宫腺肌病的随机对照试验和临床对照试验。应用Revman5.3软件进行Meta分析。结果:经筛选,纳入12篇文献,共1206例患者。Meta分析结果显示:桂枝茯苓胶囊(丸)联合曼月乐治疗子宫腺肌病临床总有效率更高(OR=3.31,95%Cl为2.12~5.18,P<0.00001),并能减轻痛经程度:慢性疼痛分级问卷法评分方法(MD=-0.46,95%CI为-0.62~-0.29,P<0.00001)和VAS评分方法(MD=-1.75,95%CI为-2.01~-1.49,P<0.00001),减少月经量(MD=-15.47,95%CI为-20.20~-10.73,P<0.00001),使子宫内膜厚度变薄(MD=-15.47,95%CI为-2.14~-2.38,P<0.00001),子宫体积缩小(MD=-16.23,95%CI为-19.45~-13.02,P<0.00001),降低血清促卵泡素(FSH)(MD=-1.30,95%CI为-1.86~-0.74,P<0.00001)、黄体生成素(LH)(MD=-1.18,95%CI为-1.37~-1.00,P<0.00001)和血清CA125水平(MD=-9.68,95%CI为-12.83~-6.54,P<0.00001),降低不良反应发生率(OR=0.53,95%CI为0.29~0.94,P=0.03)。结论:桂枝茯苓胶囊(丸)联合曼月乐治疗子宫腺肌病疗效优于单用曼月乐组,不良反应发生率低于单用曼月乐组。受纳入文献的数量和质量的限制,将来需要更大样本和高质量的研究文献,对二者联合治疗子宫腺肌病有更精确的评估。展开更多
The coupling of swirl flame with discrete plasma or particle phases offers promising opportunities in combustion control and nanomaterial synthesis.Over recent years,studies on the dynamics and stabilization of swirl ...The coupling of swirl flame with discrete plasma or particle phases offers promising opportunities in combustion control and nanomaterial synthesis.Over recent years,studies on the dynamics and stabilization of swirl flames have produced significant progress.Starting from swirl-stabilized combustion,we focus mainly on two recent trends in reviewing these new concepts in the field of combustion related to electrically/plasma-assisted dynamics control and flame aerosol synthesis of nanomaterials.We organize the material by four themes:(a)unsteady combustion dynamics and control methods;(b)electrically-and plasma-assisted combustion dynamics control;(c)swirl-flame-based synthesis of nanocomposites;and(d)in situ diagnostic methods for the complex combustion above.展开更多
文摘目的:系统评价桂枝茯苓胶囊(丸)联合曼月乐治疗子宫腺肌病的疗效和安全性。方法:运用计算机检索国家知识基础设施数据库、中国学术期刊数据库、中文科技期刊数据库、中国生物医学文献数据库、PubMed、The Cochrane Library、The Web of Science、Springer等中英文数据库从建库至2020年5月关于桂枝茯苓胶囊(丸)联合曼月乐治疗子宫腺肌病的随机对照试验和临床对照试验。应用Revman5.3软件进行Meta分析。结果:经筛选,纳入12篇文献,共1206例患者。Meta分析结果显示:桂枝茯苓胶囊(丸)联合曼月乐治疗子宫腺肌病临床总有效率更高(OR=3.31,95%Cl为2.12~5.18,P<0.00001),并能减轻痛经程度:慢性疼痛分级问卷法评分方法(MD=-0.46,95%CI为-0.62~-0.29,P<0.00001)和VAS评分方法(MD=-1.75,95%CI为-2.01~-1.49,P<0.00001),减少月经量(MD=-15.47,95%CI为-20.20~-10.73,P<0.00001),使子宫内膜厚度变薄(MD=-15.47,95%CI为-2.14~-2.38,P<0.00001),子宫体积缩小(MD=-16.23,95%CI为-19.45~-13.02,P<0.00001),降低血清促卵泡素(FSH)(MD=-1.30,95%CI为-1.86~-0.74,P<0.00001)、黄体生成素(LH)(MD=-1.18,95%CI为-1.37~-1.00,P<0.00001)和血清CA125水平(MD=-9.68,95%CI为-12.83~-6.54,P<0.00001),降低不良反应发生率(OR=0.53,95%CI为0.29~0.94,P=0.03)。结论:桂枝茯苓胶囊(丸)联合曼月乐治疗子宫腺肌病疗效优于单用曼月乐组,不良反应发生率低于单用曼月乐组。受纳入文献的数量和质量的限制,将来需要更大样本和高质量的研究文献,对二者联合治疗子宫腺肌病有更精确的评估。
基金funded mainly by the National Natural Science Foundation of China(Grant Nos.91641204 and 51676109)
文摘The coupling of swirl flame with discrete plasma or particle phases offers promising opportunities in combustion control and nanomaterial synthesis.Over recent years,studies on the dynamics and stabilization of swirl flames have produced significant progress.Starting from swirl-stabilized combustion,we focus mainly on two recent trends in reviewing these new concepts in the field of combustion related to electrically/plasma-assisted dynamics control and flame aerosol synthesis of nanomaterials.We organize the material by four themes:(a)unsteady combustion dynamics and control methods;(b)electrically-and plasma-assisted combustion dynamics control;(c)swirl-flame-based synthesis of nanocomposites;and(d)in situ diagnostic methods for the complex combustion above.
