Efficacy of transjugular intrahepatic portosystemic shunts in treating cirrhotic esophageal-gastric variceal bleeding

BACKGROUND Esophageal-gastric variceal bleeding(EGVB)represents a severe complication among patients with cirrhosis and often culminates in fatal outcomes.Interven-tional therapy,a rapidly developing treatment modality over the past few years,has found widespread application in clinical practice due to its minimally inva-sive characteristics.However,whether transjugular intrahepatic portosystemic shunt(TIPS)treatment has an impact on patient prognosis remains controversial.METHODS A retrospective study was conducted on ninety-two patients presenting with cirrhotic EGVB who were admitted to our hospital between September 2020 and September 2022.Based on the different modes of treatment,the patients were assigned to the study group(TIPS received,n=50)or the control group(per-cutaneous transhepatic varices embolization received,n=42).Comparative ana-lyses were performed between the two groups preoperatively and one month postoperatively for the following parameters:Varicosity status;hemodynamic parameters[portal vein flow velocity(PVV)and portal vein diameter(PVD);platelet count(PLT);red blood cell count;white blood cell count(WBC);and hepatic function[albumin(ALB),total bilirubin(TBIL),and aspartate transaminase(AST)].The Generic Quality of Life Inventory-74 was utilized to assess quality of life in the two groups,and the 1-year postoperative rebleeding and survival rates were compared.RESULTS Following surgical intervention,there was an improvement in the incidence of varicosity compared to the preoperative status in both cohorts.Notably,the study group exhibited more pronounced enhancements than did the control group(P<0.05).PVV increased,and PVD decreased compared to the preoperative values,with the study cohort achieving better outcomes(P<0.05).PLT and WBC counts were elevated postoperatively in the two groups,with the study cohort displaying higher PLT and WBC counts(P<0.05).No differences were detected between the two groups in terms of serum ALB,TBIL,or AST levels either preoperatively or postoperatively(P<0.05).Postoperative scores across all dimensions of life quality surpassed preoperative scores,with the study cohort achieving higher scores(P<0.05).At 22.00%,the one-year postoperative rebleeding rate in the study cohort was significantly lower than that in the control group(42.86%;P<0.05);conversely,no marked difference was obser-ved in the 1-year postoperative survival rate between the two cohorts(P>0.05).CONCLUSION TIPS,which has demonstrated robust efficacy in managing cirrhotic EGVB,remarkably alleviates varicosity and improves hemodynamics in patients.This intervention not only results in a safer profile but also contributes significantly to a more favorable prognosis.

Correlation between serum markers and transjugular intrahepatic portosystemic shunt prognosis in patients with cirrhotic ascites

BACKGROUND Individuals with refractory ascites in the context of liver cirrhosis typically face an adverse prognosis.The transjugular intrahepatic portosystemic shunt(TIPS)is an efficacious intervention,but there is a lack of reliable tools for postoperative pro-gnosis assessment.Previously utilized clinical biochemical markers,such as the serum albumin concentration(Alb),sodium(Na+)concentration,and serum creatinine(Scr),have limited predictive value.Therefore,the quest for novel,specific biomarkers to evaluate the post-TIPS prognosis in patients with liver cirrhosis and refractory ascites holds significant practical importance.A retrospective analysis was conducted on 75 patients with liver cirrhosis and refractory ascites who underwent TIPS at our institution from August 2019 to August 2021.These patients were followed up regularly for two years,and the death toll was meticulously documented.The patients were allocated into a survival group(n=45 patients)or a deceased group(n=30 patients)based on their prognosis status.The clinical data of the two groups were collected,and Child-Pugh scores and MELD scores were calculated for analysis.Spearman correlation analysis was carried out to evaluate the correlation of prognosis with Child-Pugh grade,MELD score,and Cys C level.Additionally,a multiple-factor analysis utilizing the Cox proportional hazard model was used to identify independent risk factors affecting the post-TIPS prognosis of patients with liver cirrhosis and refractory ascites.The receiver operating characteristic curve(ROC)ascertained the predictive value of the Cys C concen-tration,Child-Pugh grade,and MELD score for the prognosis of liver cirrhosis with refractory ascites in post-TIPS patients.RESULTS During a 2-year follow-up period,among 75 patients with liver cirrhosis and refractory ascites who underwent TIPS treatment,30 patients(40.00%)passed away.The deceased cohort exhibited heightened aspartate aminotrans-ferase,alanine aminotransferase,total bilirubin,Scr,prothrombin time,Cys C,international normalized ratio,Child-Pugh,and MELD scores compared to those of the survival cohort,while Alb and Na+levels were attenuated in the deceased group(P<0.05).Spearman analysis revealed moderate to high positive correlations between prognosis and Child-Pugh score,MELD score,and Cys C level(r=0.709,0.749,0.671,P<0.05).Multivariate analysis using the Cox proportional hazard model demonstrated that the independent risk factors for post-TIPS prognosis in patients with liver cirrhosis and refractory ascites were Cys C(HR=3.802;95%CI:1.313-11.015),Child-Pugh(HR=3.030;95%CI:1.858-4.943),and MELD(HR=1.222;95%CI:1.073-1.393)scores.ROC analysis confirmed that,compared to those of the classic prognostic models for Child-Pugh and MELD scores,the predictive accuracy of Cys C for post-TIPS prognosis in patients with liver cirrhosis and refractory ascites was slightly lower.This analysis yielded sensitivity and specificity values of 83.33%and 82.22%,respectively.The area under the curve value at this juncture was 0.883,with an optimal cutoff value set at 1.95 mg/L.CONCLUSION Monitoring the serum Cys C concentration is valuable for assessing the post-TIPS prognosis in patients with liver cirrhosis and refractory ascites.Predictive models based on serum Cys C levels,as opposed to Scr levels,are more beneficial for evaluating the condition and prognosis of patients with ascites due to cirrhosis.

Comparison of the application value of transvaginal ultrasound and transabdominal ultrasound in the diagnosis of ectopic pregnancy

BACKGROUND Ectopic pregnancy(EP) is one of the most common acute abdominal diseases in gynecology. Once the condition of EP is delayed, it may lead to massive hemorrhage, shock, and even death in a short time, seriously threatening the patient’s life. Early diagnosis is the key to preventing and improving the prognosis of EP.Transabdominal ultrasound(TAS) and transvaginal ultrasound(TVS) are the main diagnostic methods for abdominal diseases. The purpose of this study is to explore the application value and effect of TAS and TVS in the diagnosis of EP,hoping to provide more valuable references for the diagnosis of EP.AIM To explore the application value of TAS and TVS in the diagnosis of EP and to improve the level of clinical diagnosis.METHODS A total of 140 patients with EP admitted to our hospital from July 2018 to July 2020 were selected for this study. All patients were divided into two groups according to the examination methods. 63 patients who underwent abdominal ultrasound examination were set as the TAS group, while 77 patients who underwent TVS examination were set as the TVS group. We compared the diagnostic accuracy and misdiagnosis rates between the two types of ultrasound examinations, as well as the postoperative pathological results of the two diagnostic methods for different types of ectopic pregnancies. We also analyzed the sonograms for the presence of mixed ectopic masses,adnexal masses, ectopic gestational sacs, the presence or absence of visible embryo and fetal heart in the ectopic sac shadow, and the detection of fluid in the rectal fossa of the uterus, such as the adnexal area, yolk sac, and embryo, etc. In addition, the diagnosis time, days of gestational sac appearance, operation time, endometrial thickness, and blood flow resistance index were compared as well.RESULTS After performing both types of ultrasound examinations in 140 patients with EP, we found that the diagnostic accuracy of TVS was significantly higher than that of TAS, and the misdiagnosis rate was significantly lower than that of TAS. The differences were statistically significant(P < 0.05). In addition, the detection rate of TVS was better than that of TAS for the presence of mixed masses,adnexal masses, ectopic gestational sacs, the presence or absence of visible embryo and fetal heart in the shadow of the ectopic sac, and sonograms such as the adnexal area, yolk sac, and embryo,etc. The coincidence rate of its postoperative pathological examination results was significantly higher than those of TAS. The diagnosis time and the days of gestational sac appearance by TVS were significantly shorter than that by TAS, and the operation time was earlier than that by TAS.What’s more, the detection rates of the endometrial thickness ￡ 1.5 mm and blood flow resistance ￡0.5 were significantly higher in TVS diagnosis of EP than in TAS. All differences were statistically significant(P < 0.05).CONCLUSION Compared with TAS, TVS has the advantages of high detection accuracy and good sonogram performance.

OsNPF3.1,a member of the NRT1/PTR family,increases nitrogen use efficiency and biomass production in rice

The overuse of nitrogen(N)fertilizer in fields has increased production costs and raised environmental concerns.Increasing the N use efficiency(NUE)of rice varieties is crucial for sustainable agriculture.Here we report the cloning and characterization of OsNPF3.1,a gene that controls rice NUE.An amino acid mutation in the OsNPF3.1 coding region caused different NUEs in wild and cultivated rice.OsNPF3.1,which is expressed mainly in the aerial parts of rice,also affects rice plant height,heading date,and thousand-grain weight.The OsNPF3.1 protein is located in the plasma membrane.When OsNPF3.1 was subjected to artificial selection,two naturally varying loci were associated with NUE,of which OsNPF3.1Chr6_8741040differed between indica and japonica rice.OsNPF3.1 can be used as a new target gene for breeding rice varieties with high NUE.

Transcriptome analysis reveals potential genes associated with plant height in rice

Plant height(PH)is a complex trait regulated by the environment and multiple genes.PH directly affects crop yield,harvest index,and lodging resistance.From plant dwarf mutants,many genes related to PH have been identified and described.Nonetheless,the molecular mechanism of height regulation in high-culm rice mutants has not been well studied.By using transcriptome and weighted gene co-expression network analysis(WGCNA),we identified the differentially expressed genes(DEGs)between high-culm rice mutants(MUT)and wild-type(WT)and explored the key pathways and potential candidate genes involved in PH regulation.Transcriptome analysis identified a total of 2,184 DEGs,of which 1,317 were identified at the jointing stage and 1,512 were identified at the heading stage.Kyoto Encyclopedia of Genes and Genomes enrichment showed that the enrichment pathways were mainly involved in plant hormone signal transduction,ABC transportation,and steroid hormone biosynthesis.Among these metabolic pathways,LOC_Os05g43910 and LOC_Os01g35030 were auxin(IAA)-related genes,up-regulated in MUT and LOC_Os02g08500(LEPTO1),LOC_Os11g04720,and LOC_Os12g04500 were cytokinin(CK)-related genes,downregulated in MUT.The WGCNA identified four modules(light cyan,dark grey,grey,and pale turquoise)closely related to PH,and seven key genes were screened from these modules,of which two were up-regulated cell wallrelated genes(LOC_Os01g26174(OsWAK5),LOC_Os06g05050)in MUT,and one gibberellic acid(GA)gene(LOC_Os06g37364,OsKO2)was also up-regulated.These genes might be closely related to PH regulation.These findings help us better understand the transcriptional regulation of rice plant growth and development and provide a theoretical basis for mapping and cloning the PH regulatory genes.

Application of sintilimab combined with anlotinib hydrochloride in the clinical treatment of microsatellite stable colorectal cancer

BACKGROUND Microsatellite stable(MSS)colorectal cancer(CRC)is a common type of tumor with limited treatment options.Sintilimab and anlotinib hydrochloride are two extensively studied anticancer drugs.AIM To probe the clinical value of combining sintilimab with anlotinib hydrochloride in MSS CRC treatment.METHODS During the period spanning from April 2019 to April 2022,Zhejiang Provincial People’s Hospital accommodated a cohort of 92 patients diagnosed with MSS CRC who were classified into two distinct groups in our study,the observation group and the control group.The control group was administered anlotinib hy-drochloride as their designated therapy,whereas the observation group received the additional treatment of sintilimab in conjunction with the therapy assigned to the control group.The administration of treatment occurred in cycles consisting of a duration of 3 wk,and the evaluation of effectiveness took place subsequent to the completion of two consecutive cycles of treatment within both groups.A comparative analysis between the two groups was conducted to assess the short-term efficacy and ascertain the incidence of adverse events transpiring throughout the duration of the treatment period.Changes in the levels of carcinoembryonic Life Questionnaire-Core 30 were compared between the two groups prior to and subsequent to therapy.Finally,a 1-year follow-up was conducted for both groups of patients,and the survival status was recorded and analyzed.RESULTS The short-term effectiveness displayed by the observation group surpassed that exhibited by the control group,with a statistically significant discrepancy(76.09%vs 50.00%),reaching a significance level denoted as P<0.05.Following the administration of treatment,the observation group manifested a considerable reduction in numerous serum indicators,which were found to be lower than the corresponding pretreatment levels within the same group as well as the post-treatment levels observed in the control group(P<0.05).Post-treatment,the T lymphocyte subset levels within the observation group demonstrated a remarkable amelioration,surpassing the corresponding pre-treatment levels observed within the same group as well as the post-treatment levels observed in the control group(P<0.05).Subsequent to the therapeutic intervention,the observation group showcased a notable amelioration in the scores associated with multiple dimensions of life quality.These scores outperformed the pretreatment scores within the same group as well as the post-treatment scores observed in the control group(P<0.05).The safety levels of drug use in the two group were comparable(19.57%vs 13.04%),and no distinct difference was observed upon comparison(P>0.05).After the completion of treatment,both groups of patients underwent a 1-year follow-up outside the hospital.Throughout this period,1 patient within the observation group and 2 patients within the control group became untraceable and were lost to follow-up.During the follow-up period of the observation group,12 patients died,resulting in a survival rate of 73.33%(33/45),while in the control group,21 patients died,resulting in a survival rate of 52.27%(23/44).The implementation of Kaplan-Meier survival analysis revealed a conspicuous contrast in survival rates exhibited by the two groups(log-rank=4.710,P=0.030).CONCLUSION The combination of sintilimab and anlotinib hydrochloride demonstrated favorable efficacy in the treatment of MSS CRC patients,leading to improvements in patient immunity and prognosis.Additionally,it exerted inhibitory effects on the expression of carcinoembryonic antigen,CA199,and CA125.

Efficacy and safety analysis of transarterial chemoembolization and transarterial radioembolization in advanced hepatocellular carcinoma descending hepatectomy

BACKGROUND Hepatocellular carcinoma(HCC)is one of the most common malignant tumors in the world,which is seriously threatening the lives of patients.Due to the rapid development of the disease,patients were in the middle and advanced stages at the time of diagnosis and missed the best time for treatment.With the development of minimally invasive medicine,interventional therapy for advanced HCC has achieved promising results.Transarterial chemoembolization(TACE)and transarterial radioembolization(TARE)are currently recognized as effective treatments.This study aimed to investigate the clinical value and safety of TACE alone and combined with TACE in the treatment of progression in patients with advanced HCC and to find a breakthrough for the early diagnosis and treatment of patients with advanced HCC.AIM To investigate the efficacy and safety of hepatic TACE and TARE in advanced descending hepatectomy.METHODS In this study,218 patients with advanced HCC who were treated in the Zhejiang Provincial People’s Hospital from May 2016 to May 2021 were collected.Of the patients,119 served as the control group and received hepatic TACE,99 served as the observation group and were treated with hepatic TACE combined with TARE.The patients in two groups were compared in terms of lesion inactivation,tumor nodule size,lipiodol deposition,serum alpha-fetoprotein(AFP)level in different periods,postoperative complications,1-year survival rate,and clinical symptoms such as liver pain,fatigue,and abdominal distension,and adverse reactions such as nausea and vomiting.RESULTS The observation group and the control group had good efficacy in treatment efficiency,reduction of tumor nodules,reduction of postoperative AFP value,reduction of postoperative complications,and relief of clinical symptoms.In addition,compared with the control group,the treatment efficiency,reduction of tumor nodules,reduction of AFP value,reduction of postoperative complications,and relief of clinical symptoms in the observation group were better than those in the TACE group alone.Patients in the TACE+TARE group had a higher 1-year survival rate after surgery,lipiodol deposition was significantly increased and the extent of tumor necrosis was expanded.The overall incidence of adverse reactions in the TACE+TARE group was lower than that in the TACE group,and the difference had statistical significance(P<0.05).CONCLUSION Compared with TACE alone,TACE combined with TARE is more effective in the treatment of patients with advanced HCC.It also improves postoperative survival rate,reduces adverse effects,and has a better safety profile.

多维效能分析模式在医疗设备运行质量优化管理中的价值研究

目的:研究多维效能分析模式在医疗设备运行质量优化管理中的应用价值。方法:选取医院临床在用的91台医疗设备,随机将其分为对照组(46台)和观察组(45台),对照组采用定期质量控制管理模式;观察组采用医疗设备使用、质量控制、维护和维修4个维度的多维效能分析管理模式,并制定医疗设备运行效能的16项评估指标,采用K-Means聚类算法对医疗设备效能进行分类,制定设备管理优化措施。对比两组医疗设备多维效能评估及医疗设备运行质量评价的差异性。结果:观察组多维效能评估的使用效能、质量控制效能、维护效能和维修效能评分结果高于对照组,差异有统计学意义(t=51.664,t=43.103,t=18.201,t=21.138;P<0.05);观察组医疗设备开机率、功能完好率、维修成本增幅和服务满意度好于对照组,差异有统计学意义(t=6.036,t=10.437,t=10.817,t=7.638;P<0.05)。结论:多维效能分析模式能有效提升设备运行质量,提高设备开机率和临床服务满意度,降低设备质量缺陷发生率和维护维修费用。

SMILE手术来源的角膜基质透镜的临床研究进展

飞秒激光小切口角膜基质透镜取出术(small incision lenticule extraction,SMILE)因其良好的安全性和屈光可预测性广泛应用于近视矫正。而SMILE手术来源的角膜基质透镜作为良好的生物材料,可用于修补角膜溃疡和穿孔,治疗远视、老视、圆锥角膜等眼科疾病,逐渐成为研究热点。本文将针对SMILE手术来源的角膜基质透镜在眼科领域中的临床研究进展进行综述。

稳定型心绞痛中医药临床试验核心指标集研制

目的:本研究旨在研制适用于中医治疗稳定型心绞痛(SAP)研究的核心指标集(COS)。方法:研究通过系统评价中医药治疗SAP的文献,并对医生和SAP患者展开定性访谈,产生指标池。邀请利益相关者参加两轮在线德尔菲调查和一场面对面共识会议对指标进行评分。最后通过共识会议产生最终的 COS。结果:指标池纳入了324 个指标,在此基础上遴选出65个指标进入初始清单应用到德尔菲调查中。来自7个利益相关群体的223名参与者参与了德尔菲调查并对指标进行评分,87人完成了第一轮,47 人完成了第二轮。31名参与者参加了共识会议,最终共识包括来自4个指标域 中的6 个指标进入到最终核心指标集,包括心绞痛发作频率、心绞痛发作持续时间、西雅图心绞痛量表平板运动总时间、心血管事件和心电图 QT 间期。结论:本研究研制的COS为今后 SAP 中医临床试验中的测量和报告提供了最少指标集合。通过使用该 COS 可以减少试验间的异质性,促进利益相关者进行循证决策。

薄煤层开采与成套装备技术的发展趋势

为了实现我国薄煤层高效开采,根据煤矿科学开采发展的要求,介绍了薄煤层开采与成套装备技术发展和应用情况;指出滚筒采煤机、自动化刨煤机和连续采煤机以及无人工作面螺旋钻机开采是薄煤层综合机械化开采技术,因此全面发展综采装备、尽快国产化是发展趋势,创新发展是薄煤层开采和装备的发展方向;全面掌握刨煤机开采技术,加快刨煤机装备国产化,实现开采装备智能化;提高薄煤层滚筒采煤机装备的创新速度,实现工作面装备高适应性、高性能和高可靠性以及智能化和无人化;研制薄煤层连续采煤机,完成薄煤层开采装备充分国产化;推广螺旋钻机极薄煤层开采,进一步完善螺旋钻机开采装备。薄煤层开采技术向自动化无人工作面高产高效生产发展,而且薄煤层无煤柱开采是发展趋势。研究和发展高产高效工作面无人化薄煤层开采装备是当前的主要任务,高速高效自动化、智能化、无人化滚筒采煤机开采装备和工作面巷道煤岩掘进装备是重要工作,为煤矿数字化绿色开采、智能开采和可持续发展打下基础。

煤矿全断面岩巷掘进机开发应用与发展

为了解决煤矿开采中岩石巷道快速掘进问题,提出应研制高效智能的全断面岩巷掘进机。煤矿全断面岩巷掘进机是集全断面连续截割、支护技术、自动定位、无线遥控技术、快速装运和机械除尘等功能,实现掘、支、运一体化的快速岩巷掘进的装备。它不仅能够提高煤矿建井速度,而且能够实现煤矿高产高效安全集约化生产,为煤矿科学开采、绿色开采和可持续发展创造了条件。详细介绍了20世纪80年代我国煤矿岩巷掘进中全断面岩巷掘进机国产化工程和产品的应用情况,以及21世纪的煤矿全断面岩巷掘进机发展、应用和趋势,指出国产化、煤矿化和专业化是煤矿全断面岩巷掘进机的发展方向,产品成套化、系统化、系列化、自动化、智能化和市场化是发展趋势,煤炭精准开采、化学开采和新能源的发展是新的应用要求,可为数字煤矿和智慧煤矿及煤炭革命打下基础,对我国深层煤炭资源开发具有重大意义。

2011-2021年溧水区中型水库水质状况及富营养化趋势

对溧水区6座中型水库2011—2021年间的水质状况及富营养化状况作了分析评价。主要污染指标趋势分析表明水库氮磷质量浓度有缓慢下降趋势,NH3-N质量浓度在2018年前为跳跃式变化,2018年以后明显下降,与水环境治理措施的推进、流域内农村生活污染物减少有关,针对这些情况,研究提出了有针对性的对策和措施。

Wireless Channel Parameter Estimation Algorithms: Recent Advances and Future Challenges

Temporal and three-dimensional(3 D) spatial information is important for the characterization of wireless channels. In this paper, the commonly used array signal processing(ASP) methods to estimate channel parameters are summarized. Firstly, algorithms that can be used to estimate azimuth angle of arrival(AAo A) and elevation Ao A(EAo A) are introduced. They include multiple signal classification(MUSIC), estimation of signal parameter via rotational invariance techniques(ESPRIT), and Unitary ESPRIT algorithms. Secondly, algorithms that can be used to jointly estimate delay, AAo A, and EAo A are given. They include joint angle and delay estimation(JADE) MUSIC, JADE ESPRIT, shift-invariance(SI) JADE, and space-alternating generalized expectation-maximization(SAGE) algorithms. We also propose an improved SIJADE algorithm to further reduce computation complexity by incorporating with the Unitary ESPRIT algorithm. Performance of the above algorithms to extract only spatial information and to jointly extract temporal and spatial information is compared in both synthetic and 60 GHz real channel environments. Simulation results show that with the inclusion of delay estimation, the joint temporal and spatial estimation algorithms can provide better resolution than algorithms estimating only angles.Measurement data processing results show that MUSIC algorithm can provide comparable results with SAGE algorithm in estimating AAoA and EAoA. SI-JADE and the improved SI-JADE algorithms are also applicable to process 60 GHz channel measurement data.However, MUSIC, SI-JADE, and the improved SI-JADE algorithms can greatly reduce computational burden compared with SAGE algorithm. At last, some future directions are pointed out.

Preparation and toxicity evaluation of a novel nattokinase-tauroursodeoxycholate complex

Nattokinase(NK), which has been identified as a potent fibrinolytic protease, has remarkable potential in treatment of thrombolysis, and even has the ability to ameliorate chronic vein thrombosis. To reduce the hemorrhagic risk from an intravenous injection of NK,nattokinase-tauroursodeoxycholate(NK-TUDCA) complex was prepared at different pH values and with different ratios of NK and TUDCA. When assessing survival time, survival state,tail injury, and the body weight of mice, it was found that the NK-TUDCA complex(NK: 10 k IU/ml; TUDCA: 10 mg/ml; pH 5.0) had a lower toxicity when administered at an NK dosage of 130 kIU/kg in the acute toxicity test and 13 kIU/kg in the repeated low-dose challenge. From the results of the in vitro thrombolytic test and characterization of NKTUDCA, we speculated that the delayed release of NK-TUDCA might be the main cause of toxicity reduction by the complex. This study described the preparation of an NK complex with low toxicity following intravenous administration, which could be utilized for further clinical study of NK.

Investigation on and industrial application of degrading of methanol feed in methanol to propylene process

At present, methanol to propylene(MTP) technology developed by Lurgi Company is adopted for commercial plants and refined methanol with the purity ≥99.85 wt% is required as the feed of MTP unit in Lurgi's technology.Therefore, high energy cost for refined methanol production is one of the bottlenecks to improve the economy of MTP technology. Reducing the grade of feed refined methanol may be an effective method to save energy and reduce operation costs in MTP process. In this work, experiments and process simulation were carried out to investigate the influence and feasibility of degrading the methanol feed. Experiments were conducted to investigate the influence of crude methanol feed on conversion and selectivity of MTP reaction as well as the performance of ZSM-5 catalyst. The experimental results showed that degrading the methanol feed had no obvious influence on the conversion and selectivity of MTP reactions and the catalyst deactivation was caused by the carbon accumulation and metals deposition on the active sites. The process simulation results showed that the influence on the conversion and selectivity as well as the stream load of MTP process was negligible if 98 mol% methanol was used as feed. Finally, industrial experiments were conducted by adjusting the operation parameters to degrade of feed methanol of the commercial 500 kt·a^(-1) MTP unit of Ningmei Group in China. The results of industrial application illustrated that annually 180 kt fuel coal and 150 kt desalted water as well as 1770 MW·h^(-1) electricity would be saved when the water content increased from 0.01% to 0.4%. This work has identified the feasibility to improve MTP technology by degrading the methanol feed.

Enhanced adsorption of phenol from aqueous solution by carbonized trace ZIF-8-decorated activated carbon pellets

Trace zeolitic imidazolate framework-8(ZIF-8)-decorated activated carbon(AC)pellets were synthesized by a facile wet impregnation technique.After pyrolysis of the above composite material,the obtained carbon had a large surface area and pore volume,with traces of Zn on its surface.Subsequently,the capacity of the ZIF8/AC samples to adsorb and remove phenol from aqueous media was evaluated in both batch and column experimental setups.The equilibrium adsorption capacity reached 155.24 mg·g^(-1),which was 2.3 times greater than that of the pure AC(46.24 mg·g^(-1)).In addition,adsorption kinetics were examined by pseudofirst and pseudosecond order models,and adsorption isotherms were fitted into Langmuir and Freundlich equations.The adsorbent could be easily filtered from the solution and washed with methanol and water,while maintaining an efficiency N90% after 4 cycles.The above results make it a potentially reusable candidate for water purification.

Research on history of Chinese seismology

The history of Chinese seismology can be traced back to four thousand years before and divided into four stages,i.e.,primitive knowledge,worship of nature,perceptual knowledge and scientific research.The second stage ran in the whole Qin-Han dynasties,and the fourth stage began from Emperor Kangxi in Qing Dynasty and continued to the present.So far China has made four great contributions to seismological development of the world,i.e.,the invention of Heng Zhang＇s seismoscope,great amount of historical records of earthquakes of four thousand years,most abundant anomaly data before earthquakes,and successful practice of earthquake prediction in Haicheng.However,the seismological research in China at present is still on the junior and developing stage.Now we have been carrying on some recessively historical load in our mind such as the subconsciousness of absolute obedience,habit of phenomenological study as well as the methods of philosophical analysis without sincerity.For constructing a high-level Chinese culture in seismological research,we need to pay attention to combining the phenomenological research with experiment,observation and theory study.It is also suggested to take the appropriated measures matched with the present research level in seismology,as well as to promote coexisting and merging of multi-cultures.

MicroRNAs与癌症

MicroRNAs (miRNAs) belong to a class of noncoding, regulatory RNAs that are involved in oncogenesis and show remarkable tissue specificity.miRNAs are approximately 22 nt non-coding RNAs, which regulate gene expression in a sequence-specific manner via translational inhibition or messenger RNA (mRNA) degradation, thus affecting various cellular processes.Since the discovery of their fundamental mechanisms of action, the field of miRNAs has opened a new era in the understanding of small noncoding RNAs.Recent evidence has shown that miRNA controls cell growth, apoptosis, and differentiation.Cancer is a complex genetic disease caused by abnormalities in gene structure and expression, moreover, miRNA expression correlates with cancers and could have a crucial function in tumor progression.Bioinformatic data indicate that each miRNA can control hundreds of target genes, but identification of the accurate miRNA targets will be crucial to exploit the emerging knowledge of miRNA contribution to cancer process.

The Influence of Abnormal Segregation Band on Mechanical Properties of Hot Rolled Ferrite/Pearlite Steel Plate

In order to further reveal the influence of abnormal segregation band on mechanical properties of hot rolled ferrite/pearlite steel plate, especially on laminated tensile fracture, the experimental method of delamination tension was adopted. In this paper, the thin tensile samples with 3 mm thickness from the surface, 1/4 positions and center along the thickness orientation of test plate were measured, also the relationship between microstructure and mechanical properties was probed. The results show that the center region of hot rolled ferrite/pearlite steel plate exists granular bainite and ferrite mixed grains, which leads to lower plasticity and toughness of this region. During the tensile process, microcracks are generated and extended at the center of steel plate due to the inconsistency of deformation and fracture on the adjacent structures, finally leading to laminated fracture of steel plate.