目的分析牙周炎患者牙种植术后发生种植体周围炎的危险因素,并建立列线图预测模型。方法共203例患者纳入研究,并采用随机抽样法将其分为建模组(n=142)与验证组(n=61)。基于牙周炎患者发生种植体周围炎的独立危险因素,建立Logistic风险...目的分析牙周炎患者牙种植术后发生种植体周围炎的危险因素,并建立列线图预测模型。方法共203例患者纳入研究,并采用随机抽样法将其分为建模组(n=142)与验证组(n=61)。基于牙周炎患者发生种植体周围炎的独立危险因素,建立Logistic风险预测模型。采用Bootstrap法对模型进行内部验证,外部验证通过验证组完成。利用Hosmer-Lemeshow检验(H-L检验)和受试者工作特征(receiver operating characteristic,ROC)曲线下面积(area under the curve,AUC)对预测模型进行评价。结果吸烟史、糖尿病史、未定期行牙周治疗、种植体周围黏膜厚度<2 mm、前牙区种植和粘接固位修复等都是牙周炎患者种植后发生种植体周围炎的独立危险因素(P<0.05)。根据以上危险因素,建立预测牙周炎患者发生种植体周围炎的列线图模型。H-L检验的显著性水平为0.536。校准曲线显示,建模组和验证组的预测值与实测值基本一致。建模组AUC为0.906,表明此模型具有较好的判别效果。结论以吸烟史、糖尿病史、未能定期行牙周治疗、种植体周围黏膜厚度<2 mm、前牙区种植和粘接固位修复为预测因子构建的列线图模型可有效预测牙周炎患者发生种植体周围炎的概率。展开更多
Mycoplasma pneumonia is a common community-acquired pneumonia （CAP） in Asia. Children suffering from M. pneumoniae tend to progress quickly and develop severe pneumonia with a poor prognosis.（1） Effective manageme...Mycoplasma pneumonia is a common community-acquired pneumonia （CAP） in Asia. Children suffering from M. pneumoniae tend to progress quickly and develop severe pneumonia with a poor prognosis.（1） Effective management of M. pneumoniae infections include macrolides, tetracyclines or fluoroquinolones, however, antibiotic resistance may lead to unsatisfied clinical outcome. Chinese medicine （CM） is widely used in China and some Asian countries, which have good efficacy in the treatment of M. pneumoniae, especially for severe M. Pneumonia infection.（2） It has obvious advantages in terms of fever reduction and appetite improvement. Here we report a case of a child diagnosed with severe pneumonia who received antibiotics for 20 days but with suboptimal result, however, he experienced an optimal response to CM.展开更多
Dear Editor,Japanese encephalitis(JE)is a mosquito-borne acute neurological infectious disease caused by the Japanese encephalitis virus(JEV).Globally,68,000 cases of the disease are estimated each year,with a fatalit...Dear Editor,Japanese encephalitis(JE)is a mosquito-borne acute neurological infectious disease caused by the Japanese encephalitis virus(JEV).Globally,68,000 cases of the disease are estimated each year,with a fatality rate of as high as 30%and with approximately 30%-50%of survivors suffering from severe neurological sequelae(WHO,2015).展开更多
文摘目的分析牙周炎患者牙种植术后发生种植体周围炎的危险因素,并建立列线图预测模型。方法共203例患者纳入研究,并采用随机抽样法将其分为建模组(n=142)与验证组(n=61)。基于牙周炎患者发生种植体周围炎的独立危险因素,建立Logistic风险预测模型。采用Bootstrap法对模型进行内部验证,外部验证通过验证组完成。利用Hosmer-Lemeshow检验(H-L检验)和受试者工作特征(receiver operating characteristic,ROC)曲线下面积(area under the curve,AUC)对预测模型进行评价。结果吸烟史、糖尿病史、未定期行牙周治疗、种植体周围黏膜厚度<2 mm、前牙区种植和粘接固位修复等都是牙周炎患者种植后发生种植体周围炎的独立危险因素(P<0.05)。根据以上危险因素,建立预测牙周炎患者发生种植体周围炎的列线图模型。H-L检验的显著性水平为0.536。校准曲线显示,建模组和验证组的预测值与实测值基本一致。建模组AUC为0.906,表明此模型具有较好的判别效果。结论以吸烟史、糖尿病史、未能定期行牙周治疗、种植体周围黏膜厚度<2 mm、前牙区种植和粘接固位修复为预测因子构建的列线图模型可有效预测牙周炎患者发生种植体周围炎的概率。
文摘Mycoplasma pneumonia is a common community-acquired pneumonia （CAP） in Asia. Children suffering from M. pneumoniae tend to progress quickly and develop severe pneumonia with a poor prognosis.（1） Effective management of M. pneumoniae infections include macrolides, tetracyclines or fluoroquinolones, however, antibiotic resistance may lead to unsatisfied clinical outcome. Chinese medicine （CM） is widely used in China and some Asian countries, which have good efficacy in the treatment of M. pneumoniae, especially for severe M. Pneumonia infection.（2） It has obvious advantages in terms of fever reduction and appetite improvement. Here we report a case of a child diagnosed with severe pneumonia who received antibiotics for 20 days but with suboptimal result, however, he experienced an optimal response to CM.
文摘Dear Editor,Japanese encephalitis(JE)is a mosquito-borne acute neurological infectious disease caused by the Japanese encephalitis virus(JEV).Globally,68,000 cases of the disease are estimated each year,with a fatality rate of as high as 30%and with approximately 30%-50%of survivors suffering from severe neurological sequelae(WHO,2015).
