Optical tomography is a non-invasive technique that uses visible or near infrared radiation to analyze biological tissues. Researchers take immense attention towards advancement in optical tomography because of its lo...Optical tomography is a non-invasive technique that uses visible or near infrared radiation to analyze biological tissues. Researchers take immense attention towards advancement in optical tomography because of its low cost and an advantage of providing anatomical information. Based on the information of optical characteristics, forward and inverse problem of tomography are solved. In this research, finite element method is employed for forward problem and gradient-based optimization algorithm is developed for inverse problem of optical tomography. It is found from simulations that information about imaging is processed more distinctly and in less computational time. Normal and abnormal conditions in imaging are readily distinguished.?Simulations are carried out in Matlab. Different scenarios are developed and are simulated to validate the performance of reconstruction and optimization algorithms in optical tomography.展开更多
Background:An affordable approach accepted worldwide to successfully treat mild maternal hyperglycemia in gestational diabetes(GDM),is diet-controlled therapy.As no elaborate research was available,this study was craf...Background:An affordable approach accepted worldwide to successfully treat mild maternal hyperglycemia in gestational diabetes(GDM),is diet-controlled therapy.As no elaborate research was available,this study was crafted to investigate morphometric stereological details and to determine the mean placental oxygen diffusion capacity for patients who were kept on diet therapy for mild gestational hyperglycemia.Methods:A clinical trial(NCT04907708)was conducted from January 2018 to February 2019.A total of 70 women completed the study,out of which 35 served as healthy controls as Group A and 35 were diagnosed as mild gestational diabetics according to WHO criteria(Group B).These patients were kept on a restricted calorie diet with light exercise during gestation and were followed regularly during gestation.Soon after delivery,conserved placentas underwent complete gross,microscopic,and stereological investigations with the point and intersection-counting methods.Results:Significant differences were observed for placental width and syncytial knots(p<0.010 and 0.025 respectively)between the groups on gross and light microscopy.Most of the parameters were non-significant,though numerically more in the GDM group.On stereological details,mean placental volume,mean placental components volumes(villi,inter-villous space,fetal capillary,and fetal connective tissue),mean villi and mean fetal capillary diameter,mean villi and capillary surface density and mean morphometric diffusing capacity of placenta showed non-significant results between the groups.Conclusion:Minimal changes were observed in gross,microscopy,and morphometric stereological details in the placentae of GDM patients managed with nutritional therapy during gestation compared with the healthy controls.展开更多
文摘Optical tomography is a non-invasive technique that uses visible or near infrared radiation to analyze biological tissues. Researchers take immense attention towards advancement in optical tomography because of its low cost and an advantage of providing anatomical information. Based on the information of optical characteristics, forward and inverse problem of tomography are solved. In this research, finite element method is employed for forward problem and gradient-based optimization algorithm is developed for inverse problem of optical tomography. It is found from simulations that information about imaging is processed more distinctly and in less computational time. Normal and abnormal conditions in imaging are readily distinguished.?Simulations are carried out in Matlab. Different scenarios are developed and are simulated to validate the performance of reconstruction and optimization algorithms in optical tomography.
文摘Background:An affordable approach accepted worldwide to successfully treat mild maternal hyperglycemia in gestational diabetes(GDM),is diet-controlled therapy.As no elaborate research was available,this study was crafted to investigate morphometric stereological details and to determine the mean placental oxygen diffusion capacity for patients who were kept on diet therapy for mild gestational hyperglycemia.Methods:A clinical trial(NCT04907708)was conducted from January 2018 to February 2019.A total of 70 women completed the study,out of which 35 served as healthy controls as Group A and 35 were diagnosed as mild gestational diabetics according to WHO criteria(Group B).These patients were kept on a restricted calorie diet with light exercise during gestation and were followed regularly during gestation.Soon after delivery,conserved placentas underwent complete gross,microscopic,and stereological investigations with the point and intersection-counting methods.Results:Significant differences were observed for placental width and syncytial knots(p<0.010 and 0.025 respectively)between the groups on gross and light microscopy.Most of the parameters were non-significant,though numerically more in the GDM group.On stereological details,mean placental volume,mean placental components volumes(villi,inter-villous space,fetal capillary,and fetal connective tissue),mean villi and mean fetal capillary diameter,mean villi and capillary surface density and mean morphometric diffusing capacity of placenta showed non-significant results between the groups.Conclusion:Minimal changes were observed in gross,microscopy,and morphometric stereological details in the placentae of GDM patients managed with nutritional therapy during gestation compared with the healthy controls.
