Objective:To report the subjective and objective im-provement in vision in a patient with autosomal dominant retinitis pigmentosa after transpl antation of a sheet of fe-tal neural retina together with its r etinal pi...Objective:To report the subjective and objective im-provement in vision in a patient with autosomal dominant retinitis pigmentosa after transpl antation of a sheet of fe-tal neural retina together with its r etinal pigment ep-ithelium.Designs:A sheet of fetal n eural retina with its retinal pigment epithelium was tran splanted into the subretinal space under the fovea uni laterally in a patient with retinitis pigmentosa with visu al acuity of 20/800in the treated eye.Early Treatment Dia betic Retinopathy Study visual acuity testing,scanni ng laser ophthalmo-scope,tissue typing of the donor and recipient,fluo-rescein angiography,multifocal electroretinogram,multi-focal visually evoked potential,an d clinical examination were used.Results:No clinical evid ence of rejection was observed.There was no retinal ed ema or scarring.The transplant sheet lost its pigmen tation by 6months.Main Outcome Measures:A change in visual acuity from20/800to 20/400(7months),20/250(9months),and 20/160(1year)was observed by Early Treatment Diabetic Retinopathy Study visual a cuity testing.Inde-pendently,scanning laser ophthalm oscope testing at a different institution at 9months sh owed a visual acuity of20/270at a 40°field of view.Conclusion:This study indicates that fetal retina transpl anted with its retinal pigment epithelium can survive 1year without apparent clinical evidence of rejection and s how continued im-provement in Early Treatment Diabetic Retinopathy Study visual acuity.展开更多
文摘Objective:To report the subjective and objective im-provement in vision in a patient with autosomal dominant retinitis pigmentosa after transpl antation of a sheet of fe-tal neural retina together with its r etinal pigment ep-ithelium.Designs:A sheet of fetal n eural retina with its retinal pigment epithelium was tran splanted into the subretinal space under the fovea uni laterally in a patient with retinitis pigmentosa with visu al acuity of 20/800in the treated eye.Early Treatment Dia betic Retinopathy Study visual acuity testing,scanni ng laser ophthalmo-scope,tissue typing of the donor and recipient,fluo-rescein angiography,multifocal electroretinogram,multi-focal visually evoked potential,an d clinical examination were used.Results:No clinical evid ence of rejection was observed.There was no retinal ed ema or scarring.The transplant sheet lost its pigmen tation by 6months.Main Outcome Measures:A change in visual acuity from20/800to 20/400(7months),20/250(9months),and 20/160(1year)was observed by Early Treatment Diabetic Retinopathy Study visual a cuity testing.Inde-pendently,scanning laser ophthalm oscope testing at a different institution at 9months sh owed a visual acuity of20/270at a 40°field of view.Conclusion:This study indicates that fetal retina transpl anted with its retinal pigment epithelium can survive 1year without apparent clinical evidence of rejection and s how continued im-provement in Early Treatment Diabetic Retinopathy Study visual acuity.
