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B Cell-mediated Humoral Immunity in Chronic Hepatitis B Infection 被引量:3
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作者 Yang Li Shengxia Yin +9 位作者 rahma issa Xin Tong Guiyang Wang Juan Xia Rui Huang Guangmei Chen Dan Weng Chen Chen Chao Wu Yuxin Chen 《Journal of Clinical and Translational Hepatology》 SCIE 2021年第4期592-597,共6页
B cell-mediated humoral immunity plays a vital role in viral infections,including chronic hepatitis B virus(HBV)infection,which remains a critical global public health issue.Despite hepatitis B surface antigen-specifi... B cell-mediated humoral immunity plays a vital role in viral infections,including chronic hepatitis B virus(HBV)infection,which remains a critical global public health issue.Despite hepatitis B surface antigen-specific antibodies are essential to eliminate viral infections,the reduced immune functional capacity of B cells was identified,which was also correlated with chronic hepatitis B(CHB)progression.In addition to B cells,T follicular helper(Tfh)cells,which assist B cells to produce antibodies,might also be involved in the process of anti-HBVspecific antibody production.Here,we provide a comprehensive review of the role of various subsets of B cells and Tfh cells during CHB progression and discuss current novel treatment strategies aimed at restoring humoral immunity.Understanding the mechanism of dysregulated B cells and Tfh cells will facilitate the ultimate functional cure of CHB patients. 展开更多
关键词 Chronic hepatitis B(CHB) B cell T follicular helper(Tfh)cells ANTIBODY THERAPEUTICS
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