High resistance rates to antimicrobials continue to be a global health threat.The incidence of multidrug-resistant(MDR)microorganisms in intensive care units(ICUs)is quite high compared to in the community and other u...High resistance rates to antimicrobials continue to be a global health threat.The incidence of multidrug-resistant(MDR)microorganisms in intensive care units(ICUs)is quite high compared to in the community and other unitsin the hospital because ICU patients are generally older,have higher numbers of co-morbidities and immunesuppressed;moreover,the typically high rates of invasive procedures performed in the ICU increase the risk ofinfection by MDR microorganisms.Antimicrobial stewardship(AMS)refers to the implementation of coordinatedinterventions to improve and track the appropriate use of antibiotics while offering the best possible antibioticprescription(according to dose,duration,and route of administration).Broad-spectrum antibiotics are frequentlypreferred in ICUs because of greater infection severity and colonization and infection by MDR microorganisms.For this reason,a number of studies on AMS in ICUs have increased in recent years.Reducing the use of broadspectrum antibiotics forms the basis of AMS.For this purpose,parameters such as establishing an AMS team,limiting the use of broad-spectrum antimicrobials,terminating treatments early,using early warning systems,pursuing infection control,and providing education and feedback are used.In this review,current AMS practicesin ICUs are discussed.展开更多
文摘High resistance rates to antimicrobials continue to be a global health threat.The incidence of multidrug-resistant(MDR)microorganisms in intensive care units(ICUs)is quite high compared to in the community and other unitsin the hospital because ICU patients are generally older,have higher numbers of co-morbidities and immunesuppressed;moreover,the typically high rates of invasive procedures performed in the ICU increase the risk ofinfection by MDR microorganisms.Antimicrobial stewardship(AMS)refers to the implementation of coordinatedinterventions to improve and track the appropriate use of antibiotics while offering the best possible antibioticprescription(according to dose,duration,and route of administration).Broad-spectrum antibiotics are frequentlypreferred in ICUs because of greater infection severity and colonization and infection by MDR microorganisms.For this reason,a number of studies on AMS in ICUs have increased in recent years.Reducing the use of broadspectrum antibiotics forms the basis of AMS.For this purpose,parameters such as establishing an AMS team,limiting the use of broad-spectrum antimicrobials,terminating treatments early,using early warning systems,pursuing infection control,and providing education and feedback are used.In this review,current AMS practicesin ICUs are discussed.
