We report a disorder resembling Guillain Barre′syndrome, occurring on initia tion of simvastatin, in a 58 year old man, who had experienced a similar but m ilder episode after starting pravastatin 6 months earlier. T...We report a disorder resembling Guillain Barre′syndrome, occurring on initia tion of simvastatin, in a 58 year old man, who had experienced a similar but m ilder episode after starting pravastatin 6 months earlier. This case suggests th at acute polyradiculoneuropathy may represent a rare but serious side effect of statin treatment. It also raises the issue of the pathophysiology of acute neur opathy on statin exposure, with a hypersensitivity reaction resulting in an immu ne mediated process being possible instead of the hypothesized mitochondrial dy sfunction in chronic cases.展开更多
文摘We report a disorder resembling Guillain Barre′syndrome, occurring on initia tion of simvastatin, in a 58 year old man, who had experienced a similar but m ilder episode after starting pravastatin 6 months earlier. This case suggests th at acute polyradiculoneuropathy may represent a rare but serious side effect of statin treatment. It also raises the issue of the pathophysiology of acute neur opathy on statin exposure, with a hypersensitivity reaction resulting in an immu ne mediated process being possible instead of the hypothesized mitochondrial dy sfunction in chronic cases.
