Background: Granuloma faciale (GF) is an uncommon dermatosis of unknown pathogenesis. Multiple treatments have been proposed with varying results. We report nine cases treated successfully with cryosurgery and we revi...Background: Granuloma faciale (GF) is an uncommon dermatosis of unknown pathogenesis. Multiple treatments have been proposed with varying results. We report nine cases treated successfully with cryosurgery and we review the literature. Objectives: To study the efficacy, tolerability and safety of cryosurgery techniques in the treatment of GF. Methods: Nine immunocompetent adults with GF were treated by cryosurgery. The initiation of the therapy was preceded by a 60-day washout period in all subjects using other medication. Two different techniques were used (open-spray and contact cryo-probe). Results: All patients were treated successfully. Apart from mild postinflammatory hypopigmentation in two patients that resolved within 4 months, no other adverse event was mentioned. During an average 24-month follow-up period after the integration of therapy, no recurrences were observed. Conclusions: Cryosurgery is an efficient, safe, inexpensive, easily used method for this uncommon dermatosis, which can be proposed as a treatment of first intention.展开更多
Mefenamic acid is a commonwidely prescribed drugwith analgesic activity. Authors report two cases ofmultifocal fixed drug eruption induced by mefenamic acid. Cases were diagnosed on basis of clinical examination and h...Mefenamic acid is a commonwidely prescribed drugwith analgesic activity. Authors report two cases ofmultifocal fixed drug eruption induced by mefenamic acid. Cases were diagnosed on basis of clinical examination and histopathol-ogy of skin lesion. Only a few cases have been reported in the literature and these are the first two described in Greece.展开更多
文摘Background: Granuloma faciale (GF) is an uncommon dermatosis of unknown pathogenesis. Multiple treatments have been proposed with varying results. We report nine cases treated successfully with cryosurgery and we review the literature. Objectives: To study the efficacy, tolerability and safety of cryosurgery techniques in the treatment of GF. Methods: Nine immunocompetent adults with GF were treated by cryosurgery. The initiation of the therapy was preceded by a 60-day washout period in all subjects using other medication. Two different techniques were used (open-spray and contact cryo-probe). Results: All patients were treated successfully. Apart from mild postinflammatory hypopigmentation in two patients that resolved within 4 months, no other adverse event was mentioned. During an average 24-month follow-up period after the integration of therapy, no recurrences were observed. Conclusions: Cryosurgery is an efficient, safe, inexpensive, easily used method for this uncommon dermatosis, which can be proposed as a treatment of first intention.
文摘Mefenamic acid is a commonwidely prescribed drugwith analgesic activity. Authors report two cases ofmultifocal fixed drug eruption induced by mefenamic acid. Cases were diagnosed on basis of clinical examination and histopathol-ogy of skin lesion. Only a few cases have been reported in the literature and these are the first two described in Greece.
