Efficacy and Safety of Lianhua Qingke Tablets in the Treatment of Long Coronavirus Disease (COVID) Cough: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Clinical Study

Lianhua Qingke tablets,a patented traditional Chinese medicine that has validated clinical efficacy for treating cough caused by severe acute respiratory syndrome coronavirus 2 infection,lack rigorous evidence-based research evaluating their effect on long coronavirus disease(COVID)cough.A randomized,double-blind,placebo-controlled,multicenter clinical study was conducted among patients with long COVID cough from 19 hospitals and 23 community health centers in China.Patients were randomized 1:1 to receive either Lianhua Qingke tablets or placebo orally for 14 days(four tablets,1.84 g,three times a day).The primary endpoint indicator was the disappearance of cough,with the remission of cough also considered.Among 482 randomized patients,480(full analysis set 480;per-protocol set 470;safety set 480)were included in the primary analysis.According to the full analysis,the time until cough disappearance was significantly shorter in the trial group than in the control group,with a significant increase in the 14-day cough disappearance rate.Accordingly,the time to cough remission was significantly shorter in the trial group than in the control group.The change in the total symptom score was significantly greater in the trial group than in the control group on days 7 and 14,consistent with the results indicated by the visual analog scale(VAS)and cough evaluation test(CET)scores.No serious adverse events were recorded during the study.Lianhua Qingke tablets significantly improved the clinical symptoms of patients with long COVID cough.

A Skin-Inspired Self-Adaptive System for Temperature Control During Dynamic Wound Healing

The thermoregulating function of skin that is capable of maintaining body temperature within a thermostatic state is critical.However,patients suffering from skin damage are struggling with the surrounding scene and situational awareness.Here,we report an interactive self-regulation electronic system by mimicking the human thermos-reception system.The skin-inspired self-adaptive system is composed of two highly sensitive thermistors(thermal-response composite materials),and a low-power temperature control unit(Laserinduced graphene array).The biomimetic skin can realize self-adjusting in the range of 35–42℃,which is around physiological temperature.This thermoregulation system also contributed to skin barrier formation and wound healing.Across wound models,the treatment group healed~10%more rapidly compared with the control group,and showed reduced inflammation,thus enhancing skin tissue regeneration.The skin-inspired self-adaptive system holds substantial promise for nextgeneration robotic and medical devices.

Exsolved materials for CO_(2)reduction in high-temperature electrolysis cells

Electrochemical reduction of CO_(2)into valuable fuels and chemicals has become a contemporary research area,where the heterogeneous catalyst plays a critical role.Metal nanoparticles supported on oxides performing as active sites of electrochemical reactions have been the focus of intensive investigation.Here,we review the CO_(2)reduction with active materials prepared by exsolution.The fundamental of exsolution was summarized in terms of mechanism and models,materials,and driven forces.The advances in the exsolved materials used in hightemperature CO_(2)electrolysis were catalogued into tailored interfaces,synergistic effects on alloy particles,phase transition,reversibility and electrochemical switching.

家庭抚养模式对学前儿童安慰观念及行为的影响

在儿童早期社会化发展进程中,安慰行为虽然出现时间最晚,发生频率最低,但是对儿童的社会性发展有重要价值。不过,只有当观念与行为相一致时,儿童才有了知行统一的安慰行为。为探讨联合教养和亲代教养两种不同的家庭抚养模式对儿童安慰观念与行为及两者发展一致性的影响,本研究采用绘本故事访谈与“玩具损坏”任务范式考察173名3~6岁学前儿童的安慰观念与行为。结果显示,3~6岁儿童的安慰观念已发展到较高水平,在性别、年龄和家庭抚养模式上均不存在显著差异;3~6岁儿童的安慰行为得分随年龄增加而升高,亲代教养下安慰行为得分高于联合教养;3~6岁儿童的安慰观念与行为发展不完全一致,随年龄增加两者的一致性逐渐提高。祖辈与父辈应在遵循儿童安慰观念与行为发展规律的前提下,保持教育一致,并为儿童提供充足的互动和交往空间,为促进儿童安慰观念与行为的发展创造有利条件。

natural polymer-based bilayer adhesive skin substitute for infected burned wound healing

Thermal wounds are complex and lethal with irregular shapes, risk of infection, slow healing, and large surface area. The mortality rate in patients with infected burns is twice that of non-infected burns. Developing multifunctional skin substitutes to augment the healing rate of infected burns is vital. Herein, we 3D printed a hydrogel scaffold comprising carboxymethyl chitosan (CMCs) and oxidized alginate grafted catechol (O-AlgCat) on a hydrophobic electrospun layer, forming a bilayer skin substitute (BSS). The functional layer (FL) was fabricated by physiochemical crosslinking to ensure favorable biodegradability. The gallium-containing hydrophobic electrospun layer or backing layer (BL) could mimic the epidermis of skin, avoiding fluid penetration and offering antibacterial activity. 3D printed FL contains catechol, gallium, and biologically active platelet rich fibrin (PRF) to adhere to both tissue and BL, show antibacterial activity, encourage angiogenesis, cell growth, and migration. The fabricated bioactive BSS exhibited noticeable adhesive properties (P ≤ 0.05), significant antibacterial activity (P ≤ 0.05), faster clot formation, and the potential to promote proliferation (P ≤ 0.05) and migration (P ≤ 0.05) of L929 cells. Furthermore, the angiogenesis was significantly higher (P ≤ 0.05) when evaluated in vivo and in ovo. The BSS-covered wounds healed faster due to low inflammation and high collagen density. Based on the obtained results, the fabricated bioactive BSS could be an effective treatment for infected burn wounds.

Whirligig‑Inspired Hybrid Nanogenerator for Multi‑strategy Energy Harvesting

Portable energy solutions are highly desired in the era of the Internet of Things for powering various distributed micro-electronic devices.At the same time,the energy crisis and catastrophic global warming are becoming serious problems in the world,emphasizing the urgent need for clean and renewable energy.Here,we report a low-cost,high-performance,and portable hand-driven whirligig structured triboelectric–electromagnetic hybrid nanogenerator(whirligig-HNG)for multi-strategy energy harvesting.The whirligig-HNG comprises a dynamic supercoiling TENG via the pulling-strings and inner-distributed EMGs(variable number)in the rotator.The whirligig structure can readily convert linear displacement in low frequency into rotary motion in extremely high frequency.Based on this ingenious design,the whirligig-HNG is capable to harvest the triboelectric energy from the supercoiling/uncoiling process from the pulling strings and simultaneously utilize the high-frequency rotation energy via electromagnetic induction.We have systematically investigated the working mecha-nism of the whirligig-HNG for coupled energy harvesting and compared the individual characteristics of TENG and EMG.The whirligig-HNG is successfully demonstrated to light up more than 100 commercial light-emitting diodes(LEDs)and drive portable electronics.This research presents the enormous potential of whirligig-HNG as a manual and portable power supply for powering various portable electronics.

Polymer-based hybrid materials and their application in personal health

With unprecedented properties and functions,polymer-based hybrid materials hold extremely important position in many fields.Here in this review,we summarized applications of polymer-based hybrid materials toward personal health.Firstly,theoretical calculation and in-situ visualization used to explore the interfacial interaction and formation of hybrid materials are introduced.Secondly,applications of polymer-based hybrid materials in personal health from proactive protection(anti-bacteria and harmful gas removal),health condition monitoring(breathing and sleep)to disease diagnosis(magnetic resonance imaging),and tissue therapy(dental restoration)are discussed.Additionally,aggregation-induced emission(AIE)organic molecules based optical sensors for personal security and polymer semiconductor for organic thin film transistors are simply discussed.Finally,we present the future tendency for preparing polymer-based hybrid materials that related with personal health.

Self-powered nanofiber-based screen-print triboelectric sensors for respiratory monitoring

Scientific and commercial advances have set high requirements for wearable electronics. However, the power supply, breathability, and mass production of wearable electronics still have many challenges that need to be overcome. In this study, a self-powered nanofiber-based triboelectric sensor （SNTS） was fabricated by batch-scale fabrication technologies using electrospinning and screen-printing for health monitoring via respiratory monitoring. Typically, an arch structural SNTS is assembled by a nanofiber membrane and a Ag nanoparticle electrode. The pile of nanofibers and the conductive network of Ag nanoparticles ensure a gas channel across the whole device. The gas permeability of the SNTS was as high as 6.16 mm/s, which has overwhelming advantages when compared with commonly used wearable devices composed of air-tight cast films. Due to the softness of the nanofiber membrane, the SNTS showed excellent electronic output performance irrespective of whether it was bent, twisted, or folded. The superior properties, such as breathability, skin-friendliness, self-power, and batch fabrication of SNTS offer huge potential for their application in healthcare monitoring and multifunctional intelligent systems.

Ultra-robust triboelectric nanogenerator for harvesting rotary mechanical energy

Triboelectric nanogenerators （TENGs） for harvesting rotary mechanical energy are mostly based on in-plane sliding or free-standing mode. However, the relative displacement between two contacting triboelectric layers causes abrasion, which lowers the output power and reduces service life. Therefore, it is important to develop a method to minimize abrasion when harvesting rotary mechanical energy. Here, we report a scale-like structured TENG （SL-TENG）, in which two triboelectric layers work under a contact-separation mode to avoid in-plane relative sliding in order to minimize abrasion. As a result, the SL-TENG exhibits outstanding robustness. For example, the output voltage of the SL-TENG does not exhibit any measurable decay although this output has been continuously generated through more than a million cycles. Moreover, at a very low rotation rate of 120 rpm, the SL-TENG can generate a maximum short-drcuit current of 78 μA, delivering an instantaneous power density of 2.54 W/m^2 to an external load. In relation to this, a Li-ion battery was charged using the SL-TENG. After a 30-rain charging time, the battery achieved a discharge capacity of 0.1 mAh. Through a power management circuit integrated into the SL-TENG, a continuous direct current （DC） of 5 V is outputted, providing sufficient DC power for driving a radio-frequency wireless sensor and other conventional electronics.