A granular cell tumor (GCT) is a benign neoplasm of unclear histogenesis that is generally believed to be of nerve sheath origin.GCT is not common and most often affects the tongue,skin and soft tissue,although it may...A granular cell tumor (GCT) is a benign neoplasm of unclear histogenesis that is generally believed to be of nerve sheath origin.GCT is not common and most often affects the tongue,skin and soft tissue,although it may occur anywhere in the body.We experienced a case of GCT that arose in the cecum of a 55-yearold man.The GCT was removed by laparoscopic resection.In addition to the tumor,endoscopic examination revealed the presence of a 5-mm-polyp in the descending colon and multiple tiny polyps in the sigmoid colon and rectum.Histological examination demonstrated a cecal tumor 1.5 cm × 1.0 cm × 0.7 cm with a hard consistency;in cut sections,mixed cells with yellowish and whitish portions were seen.The tumor was located between the mucosa and subserosa,and was composed of plump histiocyte-like tumor cells with abundant granular eosinophilic cytoplasm,which were immunoreactive for S-100 protein,vimentin,neuron-specific enolase,inhibin-α and calretinin.The tumor showed extensive hyalinization and focal dystrophic calcification.Immunohistochemical profiles did not confirm any particular cell type for the histogenetic origin of the GCT,including a nerve sheath origin.Extensive hyalinization and calcifi cation showing involution of tumor cells suggest benign clinical behavior of GCT.展开更多
BACKGROUND Post-transplant lymphoproliferative disorder(PTLD) is a fatal complication of solid organ transplantation or allogenic hematopoietic stem cell transplantation that is associated with immunosuppressive thera...BACKGROUND Post-transplant lymphoproliferative disorder(PTLD) is a fatal complication of solid organ transplantation or allogenic hematopoietic stem cell transplantation that is associated with immunosuppressive therapy. Potential manifestations are diverse, ranging from reactive lymphoid hyperplasia to high-grade lymphoma.PTLD is usually of B-cell origin and associated with Epstein-Barr virus(EBV)infection. Herein, we describe a case of PTLD involving the peritoneal omentum.There has been only case of PTLD as a diffuse large B-cell lymphoma(DLBCL) in the peritoneum.CASE SUMMARY The patient was a 62-year-old man who had been receiving immunosuppressive therapy with tacrolimus since undergoing a liver transplant 15 years prior. He reported that he had experienced abdominal discomfort and anorexia 1 month prior to the current admission. Abdominal pelvic computed tomography(CT)revealed peritoneal and omental mass-like lesions without bowel obstruction.Ultrasonography-guided biopsy was performed, and he was histologically diagnosed with EBV-negative DLBCL. Positron emission tomography(PET)-CT depicted peritoneum and omentum involvement only, without any lymphadenopathy or organ masses, including in the gastrointestinal tract. Six cycles of chemotherapy with a "R-CHOP" regimen(rituximab-cyclophosphamide, doxorubicin, vincristine, prednisolone) were administered,and PET-CT performed thereafter indicated complete remission.CONCLUSION This is the first report of isolated peritoneal lymphomatosis defined as PTLD in a liver transplant recipient.展开更多
In the present study, a japonica rice （ Oryza sativa L. ） variety Nipponbare, an indica variety 9311 and a set of chromosome segment substitution lines （CSSLs） which were generated using Nipponbare as the recipien...In the present study, a japonica rice （ Oryza sativa L. ） variety Nipponbare, an indica variety 9311 and a set of chromosome segment substitution lines （CSSLs） which were generated using Nipponbare as the recipient parent and 9311 as the donor parent were used as the experimental materials. The CSSLs were grown in 2012 （normal temperature condition） and 2013 （high temperature condition） in Yangzhou, Jiangsu, and were used to map the quantitative trait loci （QTLs） for heat tolerance, based on the heat tolerance index [ （The seed setting rate under normal temperature condition -The seed setting rate under high temper- ature condition） / The seed setting rate under normal temperature condition]. As a result, three QTLs related to heat tolerance in rice were mapped on chromo- somes 2, 4 and 12, respectively. They had LOD （logarithm of rntds） scores of 2.56, 4.02 and 2.79, and contributian rates of 4.95%, 7.99% and 5.44%. Among them, qHT12.1 showed positive effect, while qHT2.1 and qHT4. t showed negative effect on heat tolerance. The results lay a foundation for the fine mapping and cloning of the QTLs and genes related to heat tolerance, and for the breeding of heat-tolerant rice varieties.展开更多
BACKGROUND Primary renal lymphoma(PRL)is extremely rare with an incidence of 0.7%among extranodal lymphomas.Occult renal lymphoma,which mimics medical renal disease and bilateral renal involvement,presents a diagnosti...BACKGROUND Primary renal lymphoma(PRL)is extremely rare with an incidence of 0.7%among extranodal lymphomas.Occult renal lymphoma,which mimics medical renal disease and bilateral renal involvement,presents a diagnostic challenge to nephrologists and radiologists as the clinical and radiological findings are mostly non-specific or inconclusive.Acute kidney injury(AKI)is not an uncommon finding in renal infiltration due to malignant lymphoma.However,only 14%of cases are detected before death,and the low diagnostic rate may be due to the non-specific clinical manifestations of renal involvement,with only 0.5%of these cases presenting with AKI.Moreover,PRL is difficult to diagnose based on clinical,biochemical,and radiologic features,especially,in the case of bilateral diffuse involvement.CASE SUMMARY Herein,we report a 74-year-old woman with primary diffuse large B-cell lymphoma who presented with AKI diagnosed by ultrasound-guided needle biopsy.We also report the clinicopathologic findings of 121 PRL cases reported since 1989,by conducting a literature review of published cases.CONCLUSION A timely renal biopsy provides the most expedient means of establishing the diagnosis.Thus,early identification of the disease by the clinician facilitates early diagnosis toward effective treatment.展开更多
基金Supported by Research funds from Chosun University,2009
文摘A granular cell tumor (GCT) is a benign neoplasm of unclear histogenesis that is generally believed to be of nerve sheath origin.GCT is not common and most often affects the tongue,skin and soft tissue,although it may occur anywhere in the body.We experienced a case of GCT that arose in the cecum of a 55-yearold man.The GCT was removed by laparoscopic resection.In addition to the tumor,endoscopic examination revealed the presence of a 5-mm-polyp in the descending colon and multiple tiny polyps in the sigmoid colon and rectum.Histological examination demonstrated a cecal tumor 1.5 cm × 1.0 cm × 0.7 cm with a hard consistency;in cut sections,mixed cells with yellowish and whitish portions were seen.The tumor was located between the mucosa and subserosa,and was composed of plump histiocyte-like tumor cells with abundant granular eosinophilic cytoplasm,which were immunoreactive for S-100 protein,vimentin,neuron-specific enolase,inhibin-α and calretinin.The tumor showed extensive hyalinization and focal dystrophic calcification.Immunohistochemical profiles did not confirm any particular cell type for the histogenetic origin of the GCT,including a nerve sheath origin.Extensive hyalinization and calcifi cation showing involution of tumor cells suggest benign clinical behavior of GCT.
基金Supported by the National Research Foundation of Korea,No.NRF-2017R1C1B5076793
文摘BACKGROUND Post-transplant lymphoproliferative disorder(PTLD) is a fatal complication of solid organ transplantation or allogenic hematopoietic stem cell transplantation that is associated with immunosuppressive therapy. Potential manifestations are diverse, ranging from reactive lymphoid hyperplasia to high-grade lymphoma.PTLD is usually of B-cell origin and associated with Epstein-Barr virus(EBV)infection. Herein, we describe a case of PTLD involving the peritoneal omentum.There has been only case of PTLD as a diffuse large B-cell lymphoma(DLBCL) in the peritoneum.CASE SUMMARY The patient was a 62-year-old man who had been receiving immunosuppressive therapy with tacrolimus since undergoing a liver transplant 15 years prior. He reported that he had experienced abdominal discomfort and anorexia 1 month prior to the current admission. Abdominal pelvic computed tomography(CT)revealed peritoneal and omental mass-like lesions without bowel obstruction.Ultrasonography-guided biopsy was performed, and he was histologically diagnosed with EBV-negative DLBCL. Positron emission tomography(PET)-CT depicted peritoneum and omentum involvement only, without any lymphadenopathy or organ masses, including in the gastrointestinal tract. Six cycles of chemotherapy with a "R-CHOP" regimen(rituximab-cyclophosphamide, doxorubicin, vincristine, prednisolone) were administered,and PET-CT performed thereafter indicated complete remission.CONCLUSION This is the first report of isolated peritoneal lymphomatosis defined as PTLD in a liver transplant recipient.
基金Supported by the National Natural Science Foundation of China(31561143008,31401354)Jiangsu Provincial Natural Science Foundation(BK20140484)Doctoral Fund of Ministry of Education of China(20133250120001)
文摘In the present study, a japonica rice （ Oryza sativa L. ） variety Nipponbare, an indica variety 9311 and a set of chromosome segment substitution lines （CSSLs） which were generated using Nipponbare as the recipient parent and 9311 as the donor parent were used as the experimental materials. The CSSLs were grown in 2012 （normal temperature condition） and 2013 （high temperature condition） in Yangzhou, Jiangsu, and were used to map the quantitative trait loci （QTLs） for heat tolerance, based on the heat tolerance index [ （The seed setting rate under normal temperature condition -The seed setting rate under high temper- ature condition） / The seed setting rate under normal temperature condition]. As a result, three QTLs related to heat tolerance in rice were mapped on chromo- somes 2, 4 and 12, respectively. They had LOD （logarithm of rntds） scores of 2.56, 4.02 and 2.79, and contributian rates of 4.95%, 7.99% and 5.44%. Among them, qHT12.1 showed positive effect, while qHT2.1 and qHT4. t showed negative effect on heat tolerance. The results lay a foundation for the fine mapping and cloning of the QTLs and genes related to heat tolerance, and for the breeding of heat-tolerant rice varieties.
基金Supported by the Research Fund from Chosun University,2020,No.2020-2.
文摘BACKGROUND Primary renal lymphoma(PRL)is extremely rare with an incidence of 0.7%among extranodal lymphomas.Occult renal lymphoma,which mimics medical renal disease and bilateral renal involvement,presents a diagnostic challenge to nephrologists and radiologists as the clinical and radiological findings are mostly non-specific or inconclusive.Acute kidney injury(AKI)is not an uncommon finding in renal infiltration due to malignant lymphoma.However,only 14%of cases are detected before death,and the low diagnostic rate may be due to the non-specific clinical manifestations of renal involvement,with only 0.5%of these cases presenting with AKI.Moreover,PRL is difficult to diagnose based on clinical,biochemical,and radiologic features,especially,in the case of bilateral diffuse involvement.CASE SUMMARY Herein,we report a 74-year-old woman with primary diffuse large B-cell lymphoma who presented with AKI diagnosed by ultrasound-guided needle biopsy.We also report the clinicopathologic findings of 121 PRL cases reported since 1989,by conducting a literature review of published cases.CONCLUSION A timely renal biopsy provides the most expedient means of establishing the diagnosis.Thus,early identification of the disease by the clinician facilitates early diagnosis toward effective treatment.
文摘目的:应用三维斑点追踪技术(three dimensional speckle tracking imaging,3D-STI)获取冠心病患者行经皮冠状动脉介入治疗(percutaneous coronary intervention,PCI)前后左室整体面积应变(global area strain,GAS)参数,并探讨面积应变参数预测PCI术后患者心功能改善的临床应用价值。方法:选取拟行PCI术的42例冠心病患者,分别于术前及术后6个月行常规三维超声心动图及3D-STI检查,记录左室舒张末期容积(end-diastolic volume,EDV)、左室收缩末期容积(end-systolic volume,ESV)、左室射血分数(left ventricular eject fraction,LVEF)、左室GAS值及PCI前后左室射血分数改变量(ΔLVEF)。根据PCI术后LVEF提高率是否≥5%将患者分为心功能改善组与未改善组,比较两组间各参数的差异并探讨面积应变参数与心功能改善间的相关性。结果:PCI术前与术后患者EDV,LVEF,ESV,LVEF,肌钙蛋白含量及GAS差异均无统计学意义(P>0.05)。与未改善组比较,改善组LVEF[(54.9±4.9)% vs (44.3±5.7)%,P<0.001],GAS[(?31.9±5.8)%vs (?26.0±5.9)%,P=0.003]均明显增高,但肌钙蛋白含量[(1.9±2.0)μg/L vs (4.0±3.4)μg/L]及ESV[(50.6±6.7) mL vs (63.2±10.9) mL]降低。冠心病患者PCI术前GAS与ΔLVEF呈正相关(r=0.58,P<0.001)。以术前GAS预测冠心病患者PCI术后心功能改善(LVEF提高率≥5%)的ROC曲线下面积为0.93,以GAS=28.9%为最佳截断点时敏感度为86.7%,特异度为88.9%。多元线性回归曲线结果显示:GAS(β=?0.73,P<0.001)可作为心功能改善的预测因素。结论:基于3D-STI的面积应变参数与PCI术后患者心功能改变相关,可用于预测冠心病患者PCI术后疗效。
