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氢溴酸加兰他敏联合甘露特钠治疗卒中后认知障碍的临床观察
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作者 郝丕达 王阳 +4 位作者 苏冉 赵晓娟 唐宽飞 刘英科 商玉玲 《阿尔茨海默病及相关病杂志》 2024年第2期110-113,共4页
目的:探讨氢溴酸加兰他敏联合甘露特钠治疗卒中后认知障碍的临床疗效。方法:选取2022年6月至2023年12月我院收治的卒中患者130例,均合并认知功能障碍,采用信封法将患者分为联合组和氢溴酸加兰他敏组,氢溴酸加兰他敏组患者使用氢溴酸加... 目的:探讨氢溴酸加兰他敏联合甘露特钠治疗卒中后认知障碍的临床疗效。方法:选取2022年6月至2023年12月我院收治的卒中患者130例,均合并认知功能障碍,采用信封法将患者分为联合组和氢溴酸加兰他敏组,氢溴酸加兰他敏组患者使用氢溴酸加兰他敏治疗,联合组患者给予氢溴酸加兰他敏与甘露特钠联合治疗,比较两组临床疗效,并对治疗前后两组患者神经功能和认知功能评分、血清HCY和NSE水平进行比较,观察两组患者不良反应发生情况。结果:相比于氢溴酸加兰他敏组,治疗后联合组患者CSS评分较低,MMSE评分较高(P<0.05)。相比于氢溴酸加兰他敏组(86.15%),联合组患者治疗疗效(95.38%)明显较高(χ^(2)=10.883,P=0.004)。治疗后联合组患者HCY和NSE水平均明显低于氢溴酸加兰他敏组(P<0.05)。联合组患者不良反应发生率(4.17%)明显低于氢溴酸加兰他敏组(16.92%)(χ^(2)=5.123,P=0.024)。结论:氢溴酸加兰他敏联合甘露特钠治疗卒中后认知障碍的临床疗效显著,可明显提高患者神经功能和认知功能,改善血清学指标,减轻不良反应,值得临床进一步推广。 展开更多
关键词 氢溴酸加兰他敏 甘露特钠 卒中后认知障碍 认知功能
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Association of serum gamma-glutamyl transferase with treatment outcome in chronic hepatitis B patients 被引量:4
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作者 Rui Huang Chen-Chen Yang +8 位作者 Yong Liu Juan Xia ran su Ya-Li Xiong Gui-Yang Wang Zhen-Hua sun Xiao-Min Yan Shan Lu Chao Wu 《World Journal of Gastroenterology》 SCIE CAS 2015年第34期9957-9965,共9页
AIM:To investigate the association of serum gammaglutamyl transferase(GGT) levels with chronic hepatitis B infection and hepatitis B e antigen(HBe Ag) seroconversion.METHODS:A retrospective study was performed on clin... AIM:To investigate the association of serum gammaglutamyl transferase(GGT) levels with chronic hepatitis B infection and hepatitis B e antigen(HBe Ag) seroconversion.METHODS:A retrospective study was performed on clinical data collected from patients who had been positive for hepatitis B surface antigen for > 6 mo and who were antiviral-treatment na?ve(n = 215) attending the Hepatitis Clinic at Nanjing Drum Tower Hospital between August 2010 and December 2013. Healthy individuals without liver disease(n = 83) were included as controls. Patients were categorized into four groups based on disease status as recommended by the European Association for the Study of the Liver:immune tolerance(IT; n = 47),HBe Ag-positive hepatitis(EPH; n = 93),HBe Ag-negative hepatitis(ENH;n = 20),and inactive carrier(IC; n = 55). Prediction of complete response(CR) based on serum GGT was also examined in EPH patients(n = 33) treated for 48 wk with nucleos(t)ide analogue(NA) therapy,including lamivudine plus adefovir combination therapy(n = 20) or entecavir monotherapy(n = 13). CR was defined as a serum hepatitis B virus DNA level < 500 copies/m L and HBe Ag seroconversion by 48 wk of treatment. RESULTS:Serum GGT levels were significantly increased in EPH and ENH patients relative to the IT,IC,and healthy control groups(P < 0.01 for all). However,no significant difference in serum GGT levels was found between the EPH and ENH groups. Baseline serum GGT levels were significantly higher in patients who achieved CR(7/33; 21.2%) compared to patients in the non-CR group(26/33; 78.8%; P = 0.011). In addition,the decline in serum GGT was greater in CR patients compared to non-CR patients after 24 wk and 48 wk of treatment(P = 0.012 and P = 0.008,respectively). The receiver operating characteristic curve yielded a sensitivity of 85.71% and a specificity of 61.54% at a threshold value of 0.89 times the upper limit of normal for baseline serum GGT in the prediction of CR following NA therapy. CONCLUSION:Serum GGT is significantly elevated in EPH and ENH patients and is a potential biomarker for the prediction of HBe Ag seroconversion following NA therapy. 展开更多
关键词 Gamma-glutamyl TRANSFERASE HEPATITIS B e ANTIGEN H
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