Objective:To study the effect of ginsenoside Rg1 on the pro-apoptosis/anti-apoptosis balance in lesions of model rats with spinal cord compression injury.Methods: Wistar rats were selected as the experimental animals ...Objective:To study the effect of ginsenoside Rg1 on the pro-apoptosis/anti-apoptosis balance in lesions of model rats with spinal cord compression injury.Methods: Wistar rats were selected as the experimental animals and randomly divided into sham operation group, compression injury group and ginsenoside group, and spinal cord compression injury models were made and then given intraperitoneal injection of 10 mg/kg ginsenoside Rg1 for intervention. 14 d after intervention, the spinal cord tissue was collected from the injured area to determine the mRNA expression of pro-apoptosis genes, anti-apoptosis genes and apoptosis-related signaling pathway genes.Results: Bcl-2, Bcl-xl, NAIP, Survivin, ERK1/2, p38MAPK, JNK, STAT3 and STAT5 mRNA expression in spinal cord tissue of compression injury group were significantly lower than those of sham operation group while Bax, caspase-3, caspase-9 and caspase-12 mRNA expression were significantly higher than those of sham operation group;Bcl-2, Bcl-xl, NAIP, Survivin, ERK1/2, p38MAPK, JNK, STAT3 and STAT5 mRNA expression in spinal cord tissue of ginsenoside group were significantly higher than those of compression injury group while Bax, caspase-3, caspase-9 and caspase-12 mRNA expression were significantly lower than those of compression injury group.Conclusion:Ginsenoside Rg1 can regulate the pro-apoptosis/anti-apoptosis balance in lesions of model rats with spinal cord compression injury.展开更多
文摘Objective:To study the effect of ginsenoside Rg1 on the pro-apoptosis/anti-apoptosis balance in lesions of model rats with spinal cord compression injury.Methods: Wistar rats were selected as the experimental animals and randomly divided into sham operation group, compression injury group and ginsenoside group, and spinal cord compression injury models were made and then given intraperitoneal injection of 10 mg/kg ginsenoside Rg1 for intervention. 14 d after intervention, the spinal cord tissue was collected from the injured area to determine the mRNA expression of pro-apoptosis genes, anti-apoptosis genes and apoptosis-related signaling pathway genes.Results: Bcl-2, Bcl-xl, NAIP, Survivin, ERK1/2, p38MAPK, JNK, STAT3 and STAT5 mRNA expression in spinal cord tissue of compression injury group were significantly lower than those of sham operation group while Bax, caspase-3, caspase-9 and caspase-12 mRNA expression were significantly higher than those of sham operation group;Bcl-2, Bcl-xl, NAIP, Survivin, ERK1/2, p38MAPK, JNK, STAT3 and STAT5 mRNA expression in spinal cord tissue of ginsenoside group were significantly higher than those of compression injury group while Bax, caspase-3, caspase-9 and caspase-12 mRNA expression were significantly lower than those of compression injury group.Conclusion:Ginsenoside Rg1 can regulate the pro-apoptosis/anti-apoptosis balance in lesions of model rats with spinal cord compression injury.
