The aim of this work is to analyse the global dynamics of an extended mathematical model of Hepatitis C virus (HCV) infection in vivo with cellular proliferation, spontaneous cure and hepatocyte homeostasis. We firstl...The aim of this work is to analyse the global dynamics of an extended mathematical model of Hepatitis C virus (HCV) infection in vivo with cellular proliferation, spontaneous cure and hepatocyte homeostasis. We firstly prove the existence of local and global solutions of the model and establish some properties of this solution as positivity and asymptotic behaviour. Secondly we show, by the construction of appropriate Lyapunov functions, that the uninfected equilibrium and the unique infected equilibrium of the mathematical model of HCV are globally asymptotically stable respectively when the threshold number and when .展开更多
文摘The aim of this work is to analyse the global dynamics of an extended mathematical model of Hepatitis C virus (HCV) infection in vivo with cellular proliferation, spontaneous cure and hepatocyte homeostasis. We firstly prove the existence of local and global solutions of the model and establish some properties of this solution as positivity and asymptotic behaviour. Secondly we show, by the construction of appropriate Lyapunov functions, that the uninfected equilibrium and the unique infected equilibrium of the mathematical model of HCV are globally asymptotically stable respectively when the threshold number and when .
