Alveolar echinococcosis(AE),caused by larval stage of Echinococcus multilocularis,is a very aggressive and potentially fatal infestation which affects primarily the liver and can metastasize to any part of the body th...Alveolar echinococcosis(AE),caused by larval stage of Echinococcus multilocularis,is a very aggressive and potentially fatal infestation which affects primarily the liver and can metastasize to any part of the body through hematogenous spread.It displays a prolonged latency period before clinical presentation,behaving like a slow-growing liver cancer with subsequent invasion of liver tissues展开更多
Alkannin/shikonin(A/S)and their derivatives are naturally occurring naphthoquinones majorly found in Boraginaceae family plants.They are integral constituents of traditional Chinese medicine Zicao(roots of Lithospermu...Alkannin/shikonin(A/S)and their derivatives are naturally occurring naphthoquinones majorly found in Boraginaceae family plants.They are integral constituents of traditional Chinese medicine Zicao(roots of Lithospermum erythrorhizon).In last two decades significant increase in pharmacological investigations on alkannin/shikonin and their derivatives has been reported that resulted in discovery of their novel mechanisms in various diseases and disorders.This review throws light on recently conducted pharmacological investigations on alkannin/shikonin and their derivatives and their outputs.Various analytical aspects are also discussed and brief summary of patent applications on inventions containing alkannin/shikonin and its derivatives is also provided.展开更多
文摘Alveolar echinococcosis(AE),caused by larval stage of Echinococcus multilocularis,is a very aggressive and potentially fatal infestation which affects primarily the liver and can metastasize to any part of the body through hematogenous spread.It displays a prolonged latency period before clinical presentation,behaving like a slow-growing liver cancer with subsequent invasion of liver tissues
文摘Alkannin/shikonin(A/S)and their derivatives are naturally occurring naphthoquinones majorly found in Boraginaceae family plants.They are integral constituents of traditional Chinese medicine Zicao(roots of Lithospermum erythrorhizon).In last two decades significant increase in pharmacological investigations on alkannin/shikonin and their derivatives has been reported that resulted in discovery of their novel mechanisms in various diseases and disorders.This review throws light on recently conducted pharmacological investigations on alkannin/shikonin and their derivatives and their outputs.Various analytical aspects are also discussed and brief summary of patent applications on inventions containing alkannin/shikonin and its derivatives is also provided.
