Early-onset colorectal cancer(EOCRC)has seen an alarming rise worldwide over the past two decades.The reason for this global trend is poorly understood.EOCRC appears to have its own unique clinical and molecular featu...Early-onset colorectal cancer(EOCRC)has seen an alarming rise worldwide over the past two decades.The reason for this global trend is poorly understood.EOCRC appears to have its own unique clinical and molecular features when compared with late-onset colorectal cancer.Younger patients appear to have more distal or rectal disease,a more advanced stage of disease at presentation,and more unfavorable histological features.Identifying risk factors for EOCRC is the first step in mitigating the rising burden of this disease.Here we summarize several noteworthy biological factors and environmental exposures that are postulated to be responsible culprits.This can hopefully translate in clinical practice to the development of better risk stratification tool for identifying highrisk individuals for early colorectal cancer screening,and identifying areas needed for further research to curb this rising trend.展开更多
Hong Kong Medical Journal(HKMJ)is the flagship general medical journal in the Hong Kong Special Administrative Region,China,with an international outlook.We are committed to publishing and promoting high-quality resea...Hong Kong Medical Journal(HKMJ)is the flagship general medical journal in the Hong Kong Special Administrative Region,China,with an international outlook.We are committed to publishing and promoting high-quality research.Led by our Editor-in-Chief,Professor Martin CS Wong,our Editorial Board is pleased to collaborate with Dr.Chen Wang,the Editor-in-Chief of the Chinese Medical Journal(CMJ),as well as the editors of CMJ to enhance the visibility of our respective journals and foster a collaborate environment that brings forth ideas and knowledge to our readers.展开更多
文摘Early-onset colorectal cancer(EOCRC)has seen an alarming rise worldwide over the past two decades.The reason for this global trend is poorly understood.EOCRC appears to have its own unique clinical and molecular features when compared with late-onset colorectal cancer.Younger patients appear to have more distal or rectal disease,a more advanced stage of disease at presentation,and more unfavorable histological features.Identifying risk factors for EOCRC is the first step in mitigating the rising burden of this disease.Here we summarize several noteworthy biological factors and environmental exposures that are postulated to be responsible culprits.This can hopefully translate in clinical practice to the development of better risk stratification tool for identifying highrisk individuals for early colorectal cancer screening,and identifying areas needed for further research to curb this rising trend.
文摘Hong Kong Medical Journal(HKMJ)is the flagship general medical journal in the Hong Kong Special Administrative Region,China,with an international outlook.We are committed to publishing and promoting high-quality research.Led by our Editor-in-Chief,Professor Martin CS Wong,our Editorial Board is pleased to collaborate with Dr.Chen Wang,the Editor-in-Chief of the Chinese Medical Journal(CMJ),as well as the editors of CMJ to enhance the visibility of our respective journals and foster a collaborate environment that brings forth ideas and knowledge to our readers.
