Non-alcoholic fatty liver disease(NAFLD)is among the most frequently encountered chronic liver diseases in everyday clinical practice.It is considered the hepatic manifestation of metabolic syndrome.Today,liver biopsy...Non-alcoholic fatty liver disease(NAFLD)is among the most frequently encountered chronic liver diseases in everyday clinical practice.It is considered the hepatic manifestation of metabolic syndrome.Today,liver biopsy is still the gold standard for NAFLD confirmation and assessing NAFLD’s possible progression to non-alcoholic steatohepatitis,fibrosis,cirrhosis,and hepatocellular carcinoma.Because of the high prevalence of NAFLD and potential associated risks of invasive diagnostic procedures,it is of great interest to recruit the patients for liver biopsy.However,as the presence of liver fibrosis determines the further clinical course,liver biopsy is expectedly reserved for those with increased fibrosis risk.The quality of liver biopsy recruitment and patient monitoring could be significantly improved by using non-invasive tools to assess liver fibrosis presence and interactive collaboration between general practitioners,gastroenterologists,and endocrinologists.As a result,the quality of liver biopsy recruitment and patients monitoring could be significantly improved.Here,we proposed clinical practice guidelines that could be implemented for everyday clinical practice in NAFLD patients.展开更多
基金This work was funded by the Ministry of Education,Science and Technological Development of the Republic of Serbia(contract number 451-03-9/2021-14/200017).
文摘Non-alcoholic fatty liver disease(NAFLD)is among the most frequently encountered chronic liver diseases in everyday clinical practice.It is considered the hepatic manifestation of metabolic syndrome.Today,liver biopsy is still the gold standard for NAFLD confirmation and assessing NAFLD’s possible progression to non-alcoholic steatohepatitis,fibrosis,cirrhosis,and hepatocellular carcinoma.Because of the high prevalence of NAFLD and potential associated risks of invasive diagnostic procedures,it is of great interest to recruit the patients for liver biopsy.However,as the presence of liver fibrosis determines the further clinical course,liver biopsy is expectedly reserved for those with increased fibrosis risk.The quality of liver biopsy recruitment and patient monitoring could be significantly improved by using non-invasive tools to assess liver fibrosis presence and interactive collaboration between general practitioners,gastroenterologists,and endocrinologists.As a result,the quality of liver biopsy recruitment and patients monitoring could be significantly improved.Here,we proposed clinical practice guidelines that could be implemented for everyday clinical practice in NAFLD patients.
