Background:The aim of this pilot study was to investigate the extent of oropharyngeal Kingella kingae carriage during the first 6 months of life.Methods:We conducted a monocentric transversal pilot study on healthy ch...Background:The aim of this pilot study was to investigate the extent of oropharyngeal Kingella kingae carriage during the first 6 months of life.Methods:We conducted a monocentric transversal pilot study on healthy children younger than 6 months in order to define the oropharyngeal carriage rate.Participants were recruited between December 2013 and September 2015 among children without symptoms or signs of invasive infections.Results:We demonstrated an oropharyngeal carriage rate of 0.67% in children younger than 6 months.Due to the really low carriage rate,it was not possible to draw statistically significant conclusion about any other characteristic of our population.Conclusions:The present study suggests that the oropharyngeal carriage of Kingella kingae among a Swiss population of healthy infants younger than 6 months is exceptional.The scarcity of colonization and disease in the early months of life suggests thus that defense against mucosai carriage and invasive infection is above all provided by vertically acquired immunity.Limited exposure of the neonates due to limited social contacts may also represent another factor avoiding neonates'mucosal Kingella kingae carriage.展开更多
文摘Background:The aim of this pilot study was to investigate the extent of oropharyngeal Kingella kingae carriage during the first 6 months of life.Methods:We conducted a monocentric transversal pilot study on healthy children younger than 6 months in order to define the oropharyngeal carriage rate.Participants were recruited between December 2013 and September 2015 among children without symptoms or signs of invasive infections.Results:We demonstrated an oropharyngeal carriage rate of 0.67% in children younger than 6 months.Due to the really low carriage rate,it was not possible to draw statistically significant conclusion about any other characteristic of our population.Conclusions:The present study suggests that the oropharyngeal carriage of Kingella kingae among a Swiss population of healthy infants younger than 6 months is exceptional.The scarcity of colonization and disease in the early months of life suggests thus that defense against mucosai carriage and invasive infection is above all provided by vertically acquired immunity.Limited exposure of the neonates due to limited social contacts may also represent another factor avoiding neonates'mucosal Kingella kingae carriage.
