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Role of NK, NKT cells and macrophages in liver transplantation 被引量:4
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作者 rené fahrner Felix Dondorf +2 位作者 Michael Ardelt Utz Settmacher Falk Rauchfuss 《World Journal of Gastroenterology》 SCIE CAS 2016年第27期6135-6144,共10页
Liver transplantation has become the treatment of choice for acute or chronic liver disease. Because the liver acts as an innate immunity-dominant organ, there are immunological differences between the liver and other... Liver transplantation has become the treatment of choice for acute or chronic liver disease. Because the liver acts as an innate immunity-dominant organ, there are immunological differences between the liver and other organs. The specific features of hepatic natural killer(NK), NKT and Kupffer cells and their role in the mechanism of liver transplant rejection, tolerance and hepatic ischemia-reperfusion injury are discussed in this review. 展开更多
关键词 Liver transplantation Natural KILLER CELLS KUPFFER CELLS GRAFT rejection ISCHEMIA-REPERFUSION injury
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Liver transplantation for hepatocellular carcinoma- factors influencing outcome and disease-free survival 被引量:2
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作者 rené fahrner Felix Dondorf +3 位作者 Michael Ardelt Yves Dittmar Utz Settmacher Falk RauchfuB 《World Journal of Gastroenterology》 SCIE CAS 2015年第42期12071-12082,共12页
Hepatocellular carcinoma is one of the leading causes of cancer-related death worldwide. Liver transplantation can be a curative treatment in selected patients. However, there are several factors that influence diseas... Hepatocellular carcinoma is one of the leading causes of cancer-related death worldwide. Liver transplantation can be a curative treatment in selected patients. However, there are several factors that influence disease-free survival after transplantation. This review addresses the pre-, intra- and postoperative factors that influence the risk of tumor recurrence after liver transplantation. 展开更多
关键词 Hepatocellular carcinoma SURVIVAL Risk factor DIAGNOSTICS RECURRENCE Liver transplantation
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Treatment options for spontaneous and postoperative sclerosing mesenteritis
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作者 Jennifer Klasen Ulrich Güller +3 位作者 Brigitte Muff Daniel Candinas Christian A Seiler rené fahrner 《World Journal of Gastrointestinal Surgery》 SCIE CAS 2016年第11期761-765,共5页
Sclerosing mesenteritis is a rare pathology with only a few described cases in the literature. The etiology is unclear; however, several potential triggers, including abdominal surgery and abdominal trauma, have been ... Sclerosing mesenteritis is a rare pathology with only a few described cases in the literature. The etiology is unclear; however, several potential triggers, including abdominal surgery and abdominal trauma, have been discussed. The pathology includes a benign acute or chronic inflammatory process affecting the adipose tissue of the mesenterium. Despite it being a rare disease, sclerosing mesenteritis is an important differential diagnosis in patients after abdominal surgery or patients presenting spontaneously with signs of acute inflammation and abdominal pain. We present here three cases with sclerosing mesenteritis. In two cases, sclerosing mesenteritis occurred postoperatively after abdominal surgery. One patient was treated because of abdominal pain and specific radiological signs revealing spontaneous manifestation of sclerosing mesenteritis. So far there are no distinct treatment algorithms, so the patients were treated differently, including steroids, antibiotics and watchful waiting. In addition, we reviewed the current literature on treatment options for this rare disease. 展开更多
关键词 SCLEROSING mesenteritis ABDOMINAL PAIN Inflammation Surgery IMMUNOSUPPRESSION
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