The first palladium/chiral nitrogenous ligand-catalyzed enantioselective addition of aryl boronic acids to various maleimides was reported.This protocol features mild conditions combined with good functional group tol...The first palladium/chiral nitrogenous ligand-catalyzed enantioselective addition of aryl boronic acids to various maleimides was reported.This protocol features mild conditions combined with good functional group tolerance.The resultant 3-arylsuccinimides were shown to be novel chiral antifungal leads and inspired the discovery of novel ligands to address the challenging issues of this transformation.展开更多
基金supported by the National Natural Science Foundation of China(No.21772094,21977049)the Natural Science Foundation of Jiangsu Province(BK20191306).
文摘The first palladium/chiral nitrogenous ligand-catalyzed enantioselective addition of aryl boronic acids to various maleimides was reported.This protocol features mild conditions combined with good functional group tolerance.The resultant 3-arylsuccinimides were shown to be novel chiral antifungal leads and inspired the discovery of novel ligands to address the challenging issues of this transformation.
