Riboflavin is an essential micronutrient for humans and must be obtained exogenously from foods or sup-plements.Numerous studies have suggested a major role of riboflavin in the prevention and treatment of various dis...Riboflavin is an essential micronutrient for humans and must be obtained exogenously from foods or sup-plements.Numerous studies have suggested a major role of riboflavin in the prevention and treatment of various diseases.There are mainly three strategies for riboflavin synthesis,including total chemical syn-thesis,chemical semi-synthesis,and microbial fermentation,the latter being currently the most promis-ing strategy.In recent years,flavinogenic microbes have attracted increasing attention.Fungi,including Eremothecium ashbyii and Ashbya gossypii,and bacteria,including Bacillus subtilis,Escherichia coli,and lac-tic acid bacteria,are ideal cell factories for riboflavin overproduction.Thus they are good candidates for enhancing the level of riboflavin in fermented foods or designing novel riboflavin bio-enriched foods with improved nutritional value and/or beneficial properties for human health.This review briefly describes the role of riboflavin in human health and the historical process of its industrial production,and then highlights riboflavin biosynthesis in bacteria and fungi,and finally summarizes the strategies for ribofla-vin overproduction based on both the optimization of fermentation conditions and the development of riboflavin-overproducing strains via chemical mutagenesis and metabolic engineering.Overall,this review provides an updated understanding of riboflavin biosynthesis and can promote the research and development of fermented food products rich in riboflavin.展开更多
Pomegranate is one of the most popular fruits worldwide,and contains many bioactive compounds,such as punicalagin,ellagic acid,and gallic acid.Pomegranate and its bioactive compounds possess varieties of health benefi...Pomegranate is one of the most popular fruits worldwide,and contains many bioactive compounds,such as punicalagin,ellagic acid,and gallic acid.Pomegranate and its bioactive compounds possess varieties of health benefits,such as antioxidant,anti-inflammatory,and antimicrobial activities,as well as the prevention and treatment of some chronic diseases,including obesity,diabetes mellitus,cardiovascular disease,liver disease,kidney disease,neurodegenerative diseases,and so on.Pomegranate has been widely utilized in the food industry,such as juice and gluten-free cake production,and its extract for extending the shelf life of food.This review paper summarizes the bioactive compounds and health benefits of pomegranate,with special attention paid to related mechanisms of action.This narrative review can provide people with an updated knowledge of the health benefits of pomegranate,and also can be helpful for the development of pomegranate into functional food and nutraceuticals.展开更多
基金supported by China Central Public-Interest Scientific Institution Basal Research Fund, Chinese Academy of Agricultural Sciences, China (Y2020XK05)the Shanghai Pujiang Talent Plan, Shanghai, China (18PJ1404600)
文摘Riboflavin is an essential micronutrient for humans and must be obtained exogenously from foods or sup-plements.Numerous studies have suggested a major role of riboflavin in the prevention and treatment of various diseases.There are mainly three strategies for riboflavin synthesis,including total chemical syn-thesis,chemical semi-synthesis,and microbial fermentation,the latter being currently the most promis-ing strategy.In recent years,flavinogenic microbes have attracted increasing attention.Fungi,including Eremothecium ashbyii and Ashbya gossypii,and bacteria,including Bacillus subtilis,Escherichia coli,and lac-tic acid bacteria,are ideal cell factories for riboflavin overproduction.Thus they are good candidates for enhancing the level of riboflavin in fermented foods or designing novel riboflavin bio-enriched foods with improved nutritional value and/or beneficial properties for human health.This review briefly describes the role of riboflavin in human health and the historical process of its industrial production,and then highlights riboflavin biosynthesis in bacteria and fungi,and finally summarizes the strategies for ribofla-vin overproduction based on both the optimization of fermentation conditions and the development of riboflavin-overproducing strains via chemical mutagenesis and metabolic engineering.Overall,this review provides an updated understanding of riboflavin biosynthesis and can promote the research and development of fermented food products rich in riboflavin.
基金funded by the Key Project of Guangdong Provincial Science and Technology Program(No.2014B020205002).
文摘Pomegranate is one of the most popular fruits worldwide,and contains many bioactive compounds,such as punicalagin,ellagic acid,and gallic acid.Pomegranate and its bioactive compounds possess varieties of health benefits,such as antioxidant,anti-inflammatory,and antimicrobial activities,as well as the prevention and treatment of some chronic diseases,including obesity,diabetes mellitus,cardiovascular disease,liver disease,kidney disease,neurodegenerative diseases,and so on.Pomegranate has been widely utilized in the food industry,such as juice and gluten-free cake production,and its extract for extending the shelf life of food.This review paper summarizes the bioactive compounds and health benefits of pomegranate,with special attention paid to related mechanisms of action.This narrative review can provide people with an updated knowledge of the health benefits of pomegranate,and also can be helpful for the development of pomegranate into functional food and nutraceuticals.
