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非ST段抬高型心肌梗死辅助诊断模型的构建与评价 被引量:1
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作者 安尼瓦尔·阿不里孜 秦练 +2 位作者 热娜·热合木丁 陈小翠 马翔 《新疆医科大学学报》 CAS 2022年第12期1403-1409,共7页
目的 基于胸痛中心临床数据对非ST段抬高型心肌梗死(Non-ST-segment elevation myocardial infarction, NSTEMI)患者的初步诊断进行准确性评价,进一步筛选诊断特征变量构建Logistic回归诊断模型以提升NSTEMI诊断的准确性。方法 纳入胸... 目的 基于胸痛中心临床数据对非ST段抬高型心肌梗死(Non-ST-segment elevation myocardial infarction, NSTEMI)患者的初步诊断进行准确性评价,进一步筛选诊断特征变量构建Logistic回归诊断模型以提升NSTEMI诊断的准确性。方法 纳入胸痛中心非ST段抬高急性冠脉综合征(Acute coronary syndrome,ACS)患者临床数据建立数据库,筛选在24 h内完成冠状动脉造影(Coronary angiography, CAG)并确诊患者的临床数据建立实验数据集,以CAG诊断结果作为衡量标准对NSTEMI患者初步诊断的准确性进行评价,基于实验数据集数据构建Logistic回归诊断模型并对模型性能进行评估。结果 NSTEMI患者初步诊断的灵敏度为88.59%,特异度为90.57%,约登指数为0.79,Kappa值为0.78,ROC曲线的AUC值为0.864。本研究所构建Logistic回归诊断模型的诊断灵敏度为93.07%,特异度为94.21%,约登指数为0.873,Kappa值为0.870,ROC曲线的AUC值为0.924。结论 Logistic回归诊断模型在NSTEMI诊断的准确性、灵敏度以及一致性方面均较胸痛中心临床数据库中NSTEMI患者初步诊断的评价指标有所提升,具有一定的临床应用价值。 展开更多
关键词 非ST段抬高型心肌梗死 急性冠脉综合征 诊断模型 评价
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深度学习在冠心病影像学诊断的研究进展 被引量:1
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作者 凯赛尔江·卡地尔 艾克力亚尔·艾尼瓦尔 +2 位作者 秦练 热娜·热合木丁 马翔 《心血管病学进展》 CAS 2022年第4期335-340,共6页
在心血管领域,医学影像与人工智能融合能深入挖掘影像数据特征,并且辅助疾病的诊断。冠心病的诊断主要依靠影像学检查,由于医生之间资历、水平的不同,个体主观原因产生的误差让诊断结果的准确性有所降低,处理数量庞大的影像数据也耗费... 在心血管领域,医学影像与人工智能融合能深入挖掘影像数据特征,并且辅助疾病的诊断。冠心病的诊断主要依靠影像学检查,由于医生之间资历、水平的不同,个体主观原因产生的误差让诊断结果的准确性有所降低,处理数量庞大的影像数据也耗费着医生大量的时间和精力。目前,深度学习作为人工智能的重要分支,在图像数据的处理上发挥着独特的优势,应用于冠心病影像诊断可提高诊断效率和准确性。现就深度学习技术在冠心病影像学诊断中的应用进行综述。 展开更多
关键词 深度学习 冠心病 医学影像 辅助诊断
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Correlation between betatrophin/angiogenin-likeprotein3/lipoprotein lipase pathway and severity of coronary artery disease in Kazakh patients with coronary heart disease 被引量:1
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作者 Lian Qin rena rehemuding +1 位作者 Aikeliyaer Ainiwaer Xiang Ma 《World Journal of Clinical Cases》 SCIE 2022年第7期2095-2105,共11页
BACKGROUND The results of previous animal experiments and clinical studies have shown that there is a correlation between expression of betatrophin and blood lipid levels.However,there are still differences studies on... BACKGROUND The results of previous animal experiments and clinical studies have shown that there is a correlation between expression of betatrophin and blood lipid levels.However,there are still differences studies on the correlation and interaction mechanism between betatrophin,angiogenin-likeprotein3(ANGPTL3)and lipoprotein lipase(LPL).In our previous studies,we found an increase in serum ANGPTL3 Levels in Chinese patients with coronary heart disease(CHD).Therefore,we retrospectively studied Kazakh CHD patients.AIM To explore the correlation between the betatrophin/ANGPTL3/LPL pathway and severity of coronary artery disease(CAD)in patients with CHD.METHODS Nondiabetic patients diagnosed with CHD were selected as the case group;79 were of Kazakh descent and 72 were of Han descent.The control groups comprised of 61 Kazakh and 65 Han individuals.The serum levels of betatrophin and LPL were detected by enzyme-linked immunosorbent assay(ELISA),and the double antibody sandwich ELISA was used to detect serum level of ANGPTL3.The levels of triglycerides,total cholesterol,and fasting blood glucose in each group were determined by an automatic biochemical analyzer.At the same time,the clinical baseline data of patients in each group were included.RESULTS Betatrophin,ANGPTL3 and LPL levels of Kazakh patients were significantly higher than those of Han patients(P=0.031,0.038,0.021 respectively).There was a positive correlation between the Gensini score and total cholesterol(TC),triglycerides(TG),low-density lipoprotein cholesterol(LDL-C),betatrophin,and LPL in Kazakh patients(r=0.204,0.453,0.352,0.471,and 0.382 respectively),(P=0.043,0.009,0.048,0.001,and P<0.001 respectively).A positive correlation was found between the Gensini score and body mass index(BMI),TC,TG,LDL-C,LPL,betatrophin in Han patients(r=0.438,0.195,0.296,0.357,0.328,and 0.446 respectively),(P=0.044,0.026,0.003,0.20,0.004,and P<0.001).TG and betatrophin were the risk factors of coronary artery disease in Kazakh patients,while BMI and betatrophin were the risk factors in Han patients.CONCLUSION There was a correlation between the betatrophin/ANGPTL3/LPL pathway and severity of CAD in patients with CHD. 展开更多
关键词 Betatrophin/angiogenin-likeprotein3/Lipoprotein lipase pathway Coronary heart disease Gensini integral Coronary artery disease
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