Hypercoagulability in cancer patients grouped by syndromes differentiated with the theory of abnormal hilit in traditional Uyghur medicine

OBJECTIVE:To investigate the relationship in malignant-neoplasm patients of hypercoagulability between syndromes differentiated with the theory of abnormal hilit in traditional Uyghur medicine(TUM).METHODS:A total of 248 patients with malignant tumors were enrolled.Based on the theory of TUM they were divided into two groups:abnormal Savda and abnormal Non-Savda(including abnormal Khan,abnormal Sepra and abnormal Belghem types);fifty healthy volunteers were selected as controls.Platelet(PLT),prothrombin time(PT),plasma fibrinogen(FIB),thrombin time(TT),activated partial thromboplastin time(aPTT)and D-Dimer(D-D)were measured in both groups.RESULTS:Compared with the control and abnor-mal Non-Savda groups,in the abnormal Savda group the PLT count increased(P<0.05),the PT was lengthened(P<0.01),and the FIB significantly increased(P<0.01).D-Ds in the three groups were significantly different(P<0.05).No significant difference was found inTT and aPTT values(P>0.05).CONCLUSION:Hypercoagulability existed in patients with malignant tumors in the different types of TUM syndromes,especially in the abnormal Savda group;this was characterized by increased blood viscosity,platelet aggregation and thrombosis.D-D appears to be a significant predictor for the therapeutic effect of TUM in relation to malignant tumor therapies.