Colorectal cancer (CRC) is one of the most malignant tumors in both sexes among all types of tumors worldwide. Up to now, no precise biomarker has been capable of accurately predicting the prognosis for patients with ...Colorectal cancer (CRC) is one of the most malignant tumors in both sexes among all types of tumors worldwide. Up to now, no precise biomarker has been capable of accurately predicting the prognosis for patients with CRC. Therefore, it is essential for us to find a new biomarker to predict the prognosis, overall survival, and disease-free survival of patients with CRC, especially for those patients who have a distant metastasis. There is a growing concern over the issues that osteopontin (OPN), a multifunction phosphorylated protein, has been identified in recent years among multiple tumors types, including CRC. There is increasing evidence showing that high expression of OPN is related to the proliferation, invasion and metastasis of CRC. OPN could support malignant formation by inducing tumor angiogenesis;aggravating the degradation of extracellular matrix;promoting chemo taxis, adhesion, and metastasis of tumors and affecting tumor immunity and apoptosis based on various complex mechanisms. More intensive studies are required in the future to clarify the roles of OPN and its related genes, relevant receptors, protein structure, biological features, and complex molecular mechanisms in colorectal carcinogenesis, as well as to develop beneficial agents for the clinical treatment of CRC to improve patient prognosis.展开更多
Dear Editor,Colorectal cancer(CRC)is an important digestive tract tumor with high malignancy.Nearly one million people suffer from CRC every year with a mortality rate of 33%.Therefore,it is urgent to determine the me...Dear Editor,Colorectal cancer(CRC)is an important digestive tract tumor with high malignancy.Nearly one million people suffer from CRC every year with a mortality rate of 33%.Therefore,it is urgent to determine the mechanism for the development of CRC,in order to find more effective diagnosis markers and therapeutic targets.Various RNA modifications have been identified in both mRNA and non-coding RNAs,with RNA methylation being the most common mRNA modification in eukaryotes.展开更多
文摘Colorectal cancer (CRC) is one of the most malignant tumors in both sexes among all types of tumors worldwide. Up to now, no precise biomarker has been capable of accurately predicting the prognosis for patients with CRC. Therefore, it is essential for us to find a new biomarker to predict the prognosis, overall survival, and disease-free survival of patients with CRC, especially for those patients who have a distant metastasis. There is a growing concern over the issues that osteopontin (OPN), a multifunction phosphorylated protein, has been identified in recent years among multiple tumors types, including CRC. There is increasing evidence showing that high expression of OPN is related to the proliferation, invasion and metastasis of CRC. OPN could support malignant formation by inducing tumor angiogenesis;aggravating the degradation of extracellular matrix;promoting chemo taxis, adhesion, and metastasis of tumors and affecting tumor immunity and apoptosis based on various complex mechanisms. More intensive studies are required in the future to clarify the roles of OPN and its related genes, relevant receptors, protein structure, biological features, and complex molecular mechanisms in colorectal carcinogenesis, as well as to develop beneficial agents for the clinical treatment of CRC to improve patient prognosis.
基金funded by Outstanding Clinical Discipline Project of Shanghai Pudong(No.PWYgy-2018-08)Program for Medical Key Departments of Shanghai(No.ZK2019A10)+4 种基金Shanghai Key Laboratory of Vascular Lesions Regulation and Remodeling(No.zdsys202002)Committee of Shanghai Science and Technology(Nos.18ZR1433900 and 17DZ2200200)Discipline Construction Promoting Project of Shanghai Pudong Hospital(Zdxk2020-01)Academic Leaders Training Program Supported by Pudong Health Bureau of Shanghai(No.PWRd2016-05)Specialty Feature Construction Project of Pudong Health and Family Planning Commission of Shanghai(No.PWZzb2017-21).
文摘Dear Editor,Colorectal cancer(CRC)is an important digestive tract tumor with high malignancy.Nearly one million people suffer from CRC every year with a mortality rate of 33%.Therefore,it is urgent to determine the mechanism for the development of CRC,in order to find more effective diagnosis markers and therapeutic targets.Various RNA modifications have been identified in both mRNA and non-coding RNAs,with RNA methylation being the most common mRNA modification in eukaryotes.
