We developed for the first time an unprecedented domino reaction of sulfonyl oximonitriles with secondary amines to streamline the synthesis of N-sulfonylformamidines in decent to high yields under mild reaction condi...We developed for the first time an unprecedented domino reaction of sulfonyl oximonitriles with secondary amines to streamline the synthesis of N-sulfonylformamidines in decent to high yields under mild reaction conditions.In addition,scale-up experiments and late-stage functionalization of drugs were also performed.Preliminary studies indicate that the loss of a cyano-/benzyloxy-group and a sulfonyl migration process are involved in this reaction.展开更多
基金This research was financially supported by the National Natural Science Foundation of China(No.21402116,21502111,21572126,22001161)the Key Science Research of Education Committee in Henan Province(no.21A150044,22A150051)Shangqiu Normal University(Program of Ecological Conservation and High-quality Development of the Old Course of Yellow River,no.2021KYFZ06).
文摘We developed for the first time an unprecedented domino reaction of sulfonyl oximonitriles with secondary amines to streamline the synthesis of N-sulfonylformamidines in decent to high yields under mild reaction conditions.In addition,scale-up experiments and late-stage functionalization of drugs were also performed.Preliminary studies indicate that the loss of a cyano-/benzyloxy-group and a sulfonyl migration process are involved in this reaction.
