The multicomponent condensation of an aryl aldehyde,acetyl chloride,acetonitrile,and enolizable ketone as one-pot synthesis of β-acetamido ketones in high yields was investigated using commercial,non-corrosive,and en...The multicomponent condensation of an aryl aldehyde,acetyl chloride,acetonitrile,and enolizable ketone as one-pot synthesis of β-acetamido ketones in high yields was investigated using commercial,non-corrosive,and environmentally benign Keggin and Wells-Dawson heteropolyacid catalysts.The best catalyst was H5PW10V2O40.The methodology used simple experimental conditions,and the short reaction times and high yields indicate it is a useful strategy for the large scale synthesis of β-acetamido ketones.展开更多
A one-pot three component Biginelli condensation of different substituted aromatic and aliphatic aldehydes with ethyl acetoacetate and urea to the respective 3,4-dihydropyrimidin-2-(1H)-ones under solvent-free conditi...A one-pot three component Biginelli condensation of different substituted aromatic and aliphatic aldehydes with ethyl acetoacetate and urea to the respective 3,4-dihydropyrimidin-2-(1H)-ones under solvent-free conditions that is simple,effective,and environmentally friendly was shown.Ammonium dihydrogen phosphate(NH4H2PO4) was used as a non-toxic,inexpensive,and easily available catalyst.The facile reaction condition and simple isolation and purification procedures of this method make it a good option for the synthesis of dihydropyrimidinones.展开更多
A rapid and efficient procedure for the preparation of various aryl-14H-dibenzo[a,j]xanthenes was reported.The method developed produced excellent yields via one-pot condensation of β-naphthol with various aryl-aldeh...A rapid and efficient procedure for the preparation of various aryl-14H-dibenzo[a,j]xanthenes was reported.The method developed produced excellent yields via one-pot condensation of β-naphthol with various aryl-aldehydes in the presence of Keggin vanadium substituted heteropolyacid,H5PW10V2O40,as catalyst under solvent free conditions.The present methodology therefore offered several advantages but not limited to excellent yields(82%-98%),short reaction times(30-50 min),mild reaction conditions,simple work-up,as well as the utilization of cheap and environmentally benign catalyst in the absence of organic solvents.展开更多
基金Partial financial support from the Research Council of Sabzevar Tarbiat Moallem University is greatly appreciated
文摘The multicomponent condensation of an aryl aldehyde,acetyl chloride,acetonitrile,and enolizable ketone as one-pot synthesis of β-acetamido ketones in high yields was investigated using commercial,non-corrosive,and environmentally benign Keggin and Wells-Dawson heteropolyacid catalysts.The best catalyst was H5PW10V2O40.The methodology used simple experimental conditions,and the short reaction times and high yields indicate it is a useful strategy for the large scale synthesis of β-acetamido ketones.
基金supported by the Research Council of Hakim Sabzevari University
文摘A one-pot three component Biginelli condensation of different substituted aromatic and aliphatic aldehydes with ethyl acetoacetate and urea to the respective 3,4-dihydropyrimidin-2-(1H)-ones under solvent-free conditions that is simple,effective,and environmentally friendly was shown.Ammonium dihydrogen phosphate(NH4H2PO4) was used as a non-toxic,inexpensive,and easily available catalyst.The facile reaction condition and simple isolation and purification procedures of this method make it a good option for the synthesis of dihydropyrimidinones.
文摘A rapid and efficient procedure for the preparation of various aryl-14H-dibenzo[a,j]xanthenes was reported.The method developed produced excellent yields via one-pot condensation of β-naphthol with various aryl-aldehydes in the presence of Keggin vanadium substituted heteropolyacid,H5PW10V2O40,as catalyst under solvent free conditions.The present methodology therefore offered several advantages but not limited to excellent yields(82%-98%),short reaction times(30-50 min),mild reaction conditions,simple work-up,as well as the utilization of cheap and environmentally benign catalyst in the absence of organic solvents.
