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G-protein-coupled estrogen receptor as a new therapeutic target for treating coronary artery disease 被引量:4
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作者 Guichun Han richard e white 《World Journal of Cardiology》 CAS 2014年第6期367-375,共9页
Coronary heart disease(CHD) continues to be the greatest mortality risk factor in the developed world. Estrogens are recognized to have great therapeutic potential to treat CHD and other cardiovascular diseases; howev... Coronary heart disease(CHD) continues to be the greatest mortality risk factor in the developed world. Estrogens are recognized to have great therapeutic potential to treat CHD and other cardiovascular diseases; however,a significant array of potentially debilitating side effects continues to limit their use. Moreover,recent clinical trials have indicated that long-term postmenopausal estrogen therapy may actually be detrimental to cardiovascular health. An exciting new development is the finding that the more recently discovered G-protein-coupled estrogen receptor(GPER) is expressed in coronary arteries-both in coronary endothelium and in smooth muscle within the vascular wall. Accumulating evidence indicates that GPER activation dilates coronary arteries and can also inhibit the prolif-eration and migration of coronary smooth muscle cells. Thus,selective GPER activation has the potential to increase coronary blood flow and possibly limit the debilitating consequences of coronary atherosclerotic disease. This review will highlight what is currently known regarding the impact of GPER activation on coronary arteries and the potential signaling mechanisms stimulated by GPER agonists in these vessels. A thorough understanding of GPER function in coronary arteries may promote the development of new therapies that would help alleviate CHD,while limiting the potentially dangerous side effects of estrogen therapy. 展开更多
关键词 G-protein-coupled estrogen receptor Coronary arteries G-1 ATHEROSCLEROSIS ESTROGEN
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多巴胺舒张猪冠状动脉及激活冠状动脉平滑肌细胞钾通道 被引量:1
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作者 韩桂春 Patricia JP McM ILLIN richard e white 《中国药理学与毒理学杂志》 CAS CSCD 北大核心 2000年第6期421-424,共4页
采用血管环实验和膜片钳细胞贴附式技术分别在器官和细胞分子水平观察多巴胺舒张猪冠状动脉作用及对平滑肌细胞大电导型钙激活钾通道(BKCa)的影响 .结果表明多巴胺引起前列腺素 F2α(PGF2α)预收缩动脉环浓度依赖性舒张反应 ,而不引起高... 采用血管环实验和膜片钳细胞贴附式技术分别在器官和细胞分子水平观察多巴胺舒张猪冠状动脉作用及对平滑肌细胞大电导型钙激活钾通道(BKCa)的影响 .结果表明多巴胺引起前列腺素 F2α(PGF2α)预收缩动脉环浓度依赖性舒张反应 ,而不引起高 K+预收缩动脉环舒张反应 .表明多巴胺引起的冠状动脉血管舒张反应依赖于 K+生理浓度梯度的存在 ,结果提示钾通道参与了多巴胺的血管舒张反应 .向细胞浴液内灌流多巴胺增强冠状动脉血管平滑肌细胞膜 BKCa通道活性 .用 DA1受体阻断剂 SCH2 3390预处理细胞 ,完全阻断多巴胺的这一作用 ,而用 β受体阻断剂普萘洛尔无影响 .提示多巴胺通过 DA1受体激活 BKCa通道引起 展开更多
关键词 多巴胺 冠状动脉 平滑肌细胞 钾通道 多胺受体
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