Introduction. Only ablative methods lead to long termremission of areas affected by Hailey- Hailey disease: excision/skin graft, cryosurgery, dermabrasion... The method using the CO2 laser is a recent addition in the ...Introduction. Only ablative methods lead to long termremission of areas affected by Hailey- Hailey disease: excision/skin graft, cryosurgery, dermabrasion... The method using the CO2 laser is a recent addition in the management of this dermatitis. We report our experience with this technique in 4 patients. Patients and methods. Carbon dioxide laser vaporization was proposed to 4 patients exhibiting Hailey- Hailey disease resistant to classical treatments. A test under local anesthesia was performed beforehand in all the patients. A 60 year- old man had an immediate reaction and refused to continue treatment. In the other 3 cases, the result of the test at 6 months was considered satisfactory. These patients were treated under general anesthesia in a single area of 50 to70 cm2, and a half- body for comparison. The CO2 laser was used in pulse mode, with successive irradiations, until a homogenous, whitish- yellow aspect with first retraction was obtained. Results. Although the healing delays were long (a mean of 1 month) and required major analgesics over the first few days, the cosmetic results were satisfactory and no abnormal scarring was observed. After a median follow- up of 27 months, no relapse of the disease other than punctiform elements was noted. All the patients wanted treatment of the other remaining affected areas be continued. In 2 patients, CO2 laser vaporization permitted treatment of areas not easily accessible to other ablative methods (around the mouth, the anus and the vulva) with anatomy and normal function spared. Discussion. These results are globally good. Although the time to healing was long, the cosmetic and functional results were always satisfactory, without abnormal scarring. Moreover, in 2 of the patients, CO2 laser was able to treat areas inaccessible to other methods. The reason for the efficacy of ablative methods is debated. Re- epidermization with keratinocytes of appendices and not expressing the molecular defect, and the constitution of dermal cicatricial tissue, are two currently proposed hypotheses.展开更多
Introduction. Miltefosine (Hexadecylphosphocholine) is a chemotherapy, which when applied locally, has demonstrated efficacy in the treatment of cutaneous metastases of breast cancer. Case report. A 79 year- old woman...Introduction. Miltefosine (Hexadecylphosphocholine) is a chemotherapy, which when applied locally, has demonstrated efficacy in the treatment of cutaneous metastases of breast cancer. Case report. A 79 year- old woman developed recurrent in transit cutaneous metastases of a squamous cell carcinoma on her left leg. All lesions completely resolved after topical applications of miltefosine. Tolerance was excellent and the patient remained disease- free 24 months after the end of the treatment. Discussion. Miltefosine, which might prove to be a simpleandeffectivealternativefortheusuallyheavytreatments proposed, warrants further assessment in this context.展开更多
文摘Introduction. Only ablative methods lead to long termremission of areas affected by Hailey- Hailey disease: excision/skin graft, cryosurgery, dermabrasion... The method using the CO2 laser is a recent addition in the management of this dermatitis. We report our experience with this technique in 4 patients. Patients and methods. Carbon dioxide laser vaporization was proposed to 4 patients exhibiting Hailey- Hailey disease resistant to classical treatments. A test under local anesthesia was performed beforehand in all the patients. A 60 year- old man had an immediate reaction and refused to continue treatment. In the other 3 cases, the result of the test at 6 months was considered satisfactory. These patients were treated under general anesthesia in a single area of 50 to70 cm2, and a half- body for comparison. The CO2 laser was used in pulse mode, with successive irradiations, until a homogenous, whitish- yellow aspect with first retraction was obtained. Results. Although the healing delays were long (a mean of 1 month) and required major analgesics over the first few days, the cosmetic results were satisfactory and no abnormal scarring was observed. After a median follow- up of 27 months, no relapse of the disease other than punctiform elements was noted. All the patients wanted treatment of the other remaining affected areas be continued. In 2 patients, CO2 laser vaporization permitted treatment of areas not easily accessible to other ablative methods (around the mouth, the anus and the vulva) with anatomy and normal function spared. Discussion. These results are globally good. Although the time to healing was long, the cosmetic and functional results were always satisfactory, without abnormal scarring. Moreover, in 2 of the patients, CO2 laser was able to treat areas inaccessible to other methods. The reason for the efficacy of ablative methods is debated. Re- epidermization with keratinocytes of appendices and not expressing the molecular defect, and the constitution of dermal cicatricial tissue, are two currently proposed hypotheses.
文摘Introduction. Miltefosine (Hexadecylphosphocholine) is a chemotherapy, which when applied locally, has demonstrated efficacy in the treatment of cutaneous metastases of breast cancer. Case report. A 79 year- old woman developed recurrent in transit cutaneous metastases of a squamous cell carcinoma on her left leg. All lesions completely resolved after topical applications of miltefosine. Tolerance was excellent and the patient remained disease- free 24 months after the end of the treatment. Discussion. Miltefosine, which might prove to be a simpleandeffectivealternativefortheusuallyheavytreatments proposed, warrants further assessment in this context.
