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Cinobufotalin as a Novel Agent to Inhibit in Vitro Epithelial Ovarian Cancer Cell Proliferation, Migration and Invasion
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作者 Anthony McDowell Syeda H. Afroze +5 位作者 richard tobin Timothy C. McCormick Martha Karen Newell-Rogers David C. Zawieja Thomas J. Kuehl Mohammad Nasir Uddin 《Open Journal of Obstetrics and Gynecology》 2016年第6期343-351,共9页
Objective: Cinobufotalin (CINO), a cardiotonic steroid (CTS) or bufadienolide, is extracted from the skin secretions of giant toads and is utilized in traditional Chinese medicine (Chan Su). CINO has been used as a ca... Objective: Cinobufotalin (CINO), a cardiotonic steroid (CTS) or bufadienolide, is extracted from the skin secretions of giant toads and is utilized in traditional Chinese medicine (Chan Su). CINO has been used as a cardiotonic, diuretic and a hemostatic agent. Recently, CINO has been shown to inhibit lung cancer cell function and has been implicated in several other disease processes. In this study, we pursued the potential anticancer application of CINO using the ovarian tumor cell line SK-OV-3. Study Design: We evaluated the effect of CINO on cultures of SK-OV-3. Cells were treated with 0.1, 0.5, 1, 5, and 10 μM CINO. Cell proliferation, migration, invasion, and viability were measured using commercially available kits. Cell cycle progression was evaluated by a Cell Cycle Phase Determination Kit. Apoptosis was evaluated by an Apoptotic Blebs Assay Kit;cell cycle arrest and apoptotic signaling were determined by fluorescence-activated cell sorting (FACS) analysis. Results: CINO at ≥ 0.5 μM inhibited SKOV-3 cell proliferation, migration, and invasion (p < 0.05). There was a higher (p < 0.05) percentage of S phase cells in groups treated with CINO at 0.5 μM. CINO at ≥ 0.5 μM down regulated expression of Proliferating Cell Nuclear Antigen (PCNA) and caused cell death. Conclusion: This data demonstrates that CINO impairs SK-OV-3 cell function via cell cycle arrest and apoptotic signaling, suggesting CINO be further investigated as a novel anti-ovarian cancer agent. 展开更多
关键词 Cinobufotalin Ovarian Cancer SK-OV-3 Apoptosis Cell Cycle Arrest
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Spartan-6实现智能驱动控制系统可扩展设计方案
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作者 Kasper Feurer richard tobin 《电子设计技术 EDN CHINA》 2011年第7期60-61,共2页
智能驱动器以及许多汽车和ISM厂商正面临着满足新的市场需求和不断发展的标准要求所带来的重重挑战。在现代工业和汽车应用中,电机必须具有高效、低噪声、速度范围宽、可靠性高、成本合理等特性。在当今工厂里,电机驱动型设备占总耗电... 智能驱动器以及许多汽车和ISM厂商正面临着满足新的市场需求和不断发展的标准要求所带来的重重挑战。在现代工业和汽车应用中,电机必须具有高效、低噪声、速度范围宽、可靠性高、成本合理等特性。在当今工厂里,电机驱动型设备占总耗电量的三分之二,因此开发能效更高的系统势在必行。 展开更多
关键词 Spartan-6 智能驱动器 SP605 赛灵思
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