Superfici alacral fibromyxoma(SAFM)is arecently recognized myxoid tumor that u sually occurs on the fingers and toes of middle-aged adults. We report on the t ypical case of a 50-yearold woman with a SAFM in the right...Superfici alacral fibromyxoma(SAFM)is arecently recognized myxoid tumor that u sually occurs on the fingers and toes of middle-aged adults. We report on the t ypical case of a 50-yearold woman with a SAFM in the right big toenail that had been slowly growing for more than 10 years. To our knowledge, this case is the first reported case for which clinical pictures are available. Histologically, t he lesion was non-encapsulated and was composed of stellate and spindle cells, arranged in a myxoid matrix. No atypia or mitotic figures were found. Neoplastic cells showed positive staining for CD34 and negative staining for epithelial me mbrane antigen (EMA), actin, desmin, keratins, S100 protein, CD99, and HMB45. Di fferential diagnosis encompasses benign and malignant myxoid and spindle cells t umors such as myxoid neurofibroma, sclerosing perineurioma, superficial angiomyx oma, and several low-grade myxoid sarcomas.展开更多
Nail changes occur in about 25%of systemic lupus erythematosus (SLE) cases. Onycholysis has been reported as the most frequent abnormality in SLE. Nailbed hyperkeratosis may be observed in both SLE and discoid lupus e...Nail changes occur in about 25%of systemic lupus erythematosus (SLE) cases. Onycholysis has been reported as the most frequent abnormality in SLE. Nailbed hyperkeratosis may be observed in both SLE and discoid lupus erythematosus (DLE). Involvement of the nail apparatus in DLE is extremely uncommon and never restricted to it. We report on a patient in whom the clinical features on the proximal nailfold were similar to those observed on the skin of a patient with typical DLE.This has, to the best of our knowledge, not yet been reported. The patient also exhibited a very distinctive prominent subungual hyperkeratosis. Interestingly, the patient developed biological alterations suggesting a systematization of the disease. Only a combination of systemic corticoids, retinoids and antimalarials was able to achieve nail improvement and this partial resistance to therapy may be explained by the very unusual subungual hyperkeratosis.展开更多
Lipomas are one of the most common benign soft tissue tumors.The usual development sites are the neck, the torso, and the legs.Lipomas of the nail unit are extremely rare.Only five cases have been reported up to now, ...Lipomas are one of the most common benign soft tissue tumors.The usual development sites are the neck, the torso, and the legs.Lipomas of the nail unit are extremely rare.Only five cases have been reported up to now, four in subungual locations and one in the lateral nail fold.We report three cases of peri-ungual lipomas, one on the digit and two on the toes.Two of them exhibited the histological features of perisudoral lipomas.展开更多
文摘Superfici alacral fibromyxoma(SAFM)is arecently recognized myxoid tumor that u sually occurs on the fingers and toes of middle-aged adults. We report on the t ypical case of a 50-yearold woman with a SAFM in the right big toenail that had been slowly growing for more than 10 years. To our knowledge, this case is the first reported case for which clinical pictures are available. Histologically, t he lesion was non-encapsulated and was composed of stellate and spindle cells, arranged in a myxoid matrix. No atypia or mitotic figures were found. Neoplastic cells showed positive staining for CD34 and negative staining for epithelial me mbrane antigen (EMA), actin, desmin, keratins, S100 protein, CD99, and HMB45. Di fferential diagnosis encompasses benign and malignant myxoid and spindle cells t umors such as myxoid neurofibroma, sclerosing perineurioma, superficial angiomyx oma, and several low-grade myxoid sarcomas.
文摘Nail changes occur in about 25%of systemic lupus erythematosus (SLE) cases. Onycholysis has been reported as the most frequent abnormality in SLE. Nailbed hyperkeratosis may be observed in both SLE and discoid lupus erythematosus (DLE). Involvement of the nail apparatus in DLE is extremely uncommon and never restricted to it. We report on a patient in whom the clinical features on the proximal nailfold were similar to those observed on the skin of a patient with typical DLE.This has, to the best of our knowledge, not yet been reported. The patient also exhibited a very distinctive prominent subungual hyperkeratosis. Interestingly, the patient developed biological alterations suggesting a systematization of the disease. Only a combination of systemic corticoids, retinoids and antimalarials was able to achieve nail improvement and this partial resistance to therapy may be explained by the very unusual subungual hyperkeratosis.
文摘Lipomas are one of the most common benign soft tissue tumors.The usual development sites are the neck, the torso, and the legs.Lipomas of the nail unit are extremely rare.Only five cases have been reported up to now, four in subungual locations and one in the lateral nail fold.We report three cases of peri-ungual lipomas, one on the digit and two on the toes.Two of them exhibited the histological features of perisudoral lipomas.
