The oral mucosa is vascularized,drugs can be absorbed directly and can enter the systemic circulation without firstpass metabolism[1].This advantage can be used in preparing products with increased oral bioavailabilit...The oral mucosa is vascularized,drugs can be absorbed directly and can enter the systemic circulation without firstpass metabolism[1].This advantage can be used in preparing products with increased oral bioavailability of molecules that undergo first pass metabolism.Thus oral mucosa is an attractive site for drug delivery[2,3].The objective of this research work is to formulate mouth dissolving film of nifedipine for enhanced bioavailability.nifedipine is used to treat hypertension and angina pectoris.展开更多
文摘The oral mucosa is vascularized,drugs can be absorbed directly and can enter the systemic circulation without firstpass metabolism[1].This advantage can be used in preparing products with increased oral bioavailability of molecules that undergo first pass metabolism.Thus oral mucosa is an attractive site for drug delivery[2,3].The objective of this research work is to formulate mouth dissolving film of nifedipine for enhanced bioavailability.nifedipine is used to treat hypertension and angina pectoris.
