期刊文献+
共找到1篇文章
< 1 >
每页显示 20 50 100
加巴喷丁对症治疗莱姆病晚期患者的慢性神经性疼痛:1项前导性研究
1
作者 Weissenbacher S. ring j. +1 位作者 Hofmann H. 焦婷 《世界核心医学期刊文摘(皮肤病学分册)》 2005年第11期44-45,共2页
Background: Chronic neuropathic pain occurs in 10-15%of patients with neuroborreliosis and is difficult to treat. Objective: We evaluated the effect of gabapentin monotherapy on residual pain in patients with neurobor... Background: Chronic neuropathic pain occurs in 10-15%of patients with neuroborreliosis and is difficult to treat. Objective: We evaluated the effect of gabapentin monotherapy on residual pain in patients with neuroborreliosis after intravenous ceftriaxone treatment. Methods: Ten patients with neuroborreliosis and a long-lasting history of neurologic symptoms were treated with gabapentin, starting with 300 mg/day. Doses were raised over a period of 4-12 weeks to the individually effective and tolerated maximum dose (500-1,200 mg). Treatment was maintained until pain disappeared and then gradually reduced in dose over weeks. If symptoms recurred, the doses were raised again. Therapy was maintained over an average of 1-2 years. Results: Pain quality and pain quantity were evaluated using the McGill pain questionnaire and a visual analogue scale. There was an improvement of ‘crawling’and ‘burning’pain sensations, neck and radiating lumbar pain in 9/10 (90%) patients as well as a positive effect on mood, general feeling of health and quality of sleep in 5/10 (50%) patients. The average dose leading to a clear-cut pain reduction was 700 mg. Conclusions: In an open pilot study (10 patients), gabapentin monotherapy which has to our knowledge not been published as treatment of chronic neuropathic pain in patients with late Lyme borreliosis is efficacious in treating pain associated with neuroborreliosis and can thus improve quality of life in these patients. 展开更多
关键词 莱姆病 加巴喷丁 神经性疼痛 对症治疗 前导性 游走性疼痛 评估单 睡眠质量 视觉模拟评分法 一般健康状况
下载PDF
上一页 1 下一页 到第
使用帮助 返回顶部