Phosphatase and tensin homolog (PTEN) is a tumor suppressor gene and has a role in inhibiting the oncogenic AKT signaling pathway by dephosphorylating phosphatidylinositol 3,4,5-triphosphate (PIP3 ) into phosphatidyli...Phosphatase and tensin homolog (PTEN) is a tumor suppressor gene and has a role in inhibiting the oncogenic AKT signaling pathway by dephosphorylating phosphatidylinositol 3,4,5-triphosphate (PIP3 ) into phosphatidylinositol 4,5-bisphosphate (PIP2 ). The function of PTEN is regulated by different mechanisms and inactive PTEN results in aggressive tumor phenotype and tumorigenesis. Identifying targeted therapies for inactive tumor suppressor genes such as PTEN has been challenging as it is difficult to restore the tumor suppressor functions. Therefore, focusing on the downstream signaling pathways to discover a targeted therapy for inactive tumor suppressor genes has highlighted the importance of synthetic lethality studies. This review focused on the potential synthetic lethality genes discovered in PTEN-inactive cancer types. These discovered genes could be potential targeted therapies for PTEN-inactive cancer types and may improve the treatment response rates for aggressive types of cancer.展开更多
Dear Editor,The pandemic of COVID-19,a disease caused by severe acute respiratory syndrome coronavirus 2(SARS-Co V-2;previously known as 2019-n Co V),has placed an enormous burden on health authorities in 213 countrie...Dear Editor,The pandemic of COVID-19,a disease caused by severe acute respiratory syndrome coronavirus 2(SARS-Co V-2;previously known as 2019-n Co V),has placed an enormous burden on health authorities in 213 countries and territories.At the time of writing,over 26 million cases have been recorded across the world,with more than 870 k associated deaths(www.worldometers.info/coronavirus/).World Bank warns COVID-19 pandemic risks dramatic rise in poverty,with the majority of economies expecting to suffer from falling levels of GDP in 2020.展开更多
基金supported by an Academy of Medical Sciences,United Kingdom/the Wellcome Trust Springboard Award(No.SBF002\1038)the Medical Research Council,United Kingdom(No.MR/S025480/1)+1 种基金supported by the Wessex Medical Trust,United KingdomFor the purpose of open access,the authors have applied a CC-BY public copyright license to any Author Accepted Manuscript version arising from this submission.
文摘Phosphatase and tensin homolog (PTEN) is a tumor suppressor gene and has a role in inhibiting the oncogenic AKT signaling pathway by dephosphorylating phosphatidylinositol 3,4,5-triphosphate (PIP3 ) into phosphatidylinositol 4,5-bisphosphate (PIP2 ). The function of PTEN is regulated by different mechanisms and inactive PTEN results in aggressive tumor phenotype and tumorigenesis. Identifying targeted therapies for inactive tumor suppressor genes such as PTEN has been challenging as it is difficult to restore the tumor suppressor functions. Therefore, focusing on the downstream signaling pathways to discover a targeted therapy for inactive tumor suppressor genes has highlighted the importance of synthetic lethality studies. This review focused on the potential synthetic lethality genes discovered in PTEN-inactive cancer types. These discovered genes could be potential targeted therapies for PTEN-inactive cancer types and may improve the treatment response rates for aggressive types of cancer.
基金funded by Medical Research Council(UK)[MR/S025480/1]a Key Project of Science and Technology on COVID-19 of Hubei Province[No.2020FCA002]supported by an Institute for Life Sciences(University of Southampton)PhD Studentship。
文摘Dear Editor,The pandemic of COVID-19,a disease caused by severe acute respiratory syndrome coronavirus 2(SARS-Co V-2;previously known as 2019-n Co V),has placed an enormous burden on health authorities in 213 countries and territories.At the time of writing,over 26 million cases have been recorded across the world,with more than 870 k associated deaths(www.worldometers.info/coronavirus/).World Bank warns COVID-19 pandemic risks dramatic rise in poverty,with the majority of economies expecting to suffer from falling levels of GDP in 2020.
